Skip to main content
SpringerLink
Log in
Book cover

NMR as a Structural Tool for Macromolecules

Current Status and Future Directions

  • Book
  • © 1996

Overview

Editors:
  1. B. D. Nageswara Rao

    1. Indiana University-Purdue University, Indianapolis (IUPUI), Indianapolis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Marvin D. Kemple

    1. Indiana University-Purdue University, Indianapolis (IUPUI), Indianapolis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (24 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Theme of the Symposium

    • B. D. Nageswara Rao
    Pages 1-13

  3. Intramolecular Dynamics of Biomolecules, Possibilities and Limitations of NMR

    • R. R. Ernst, M. J. Blackledge, T. Bremi, R. Brüschweiler, M. Ernst, C. Griesinger et al.
    Pages 15-30

  4. Structural, Dynamic, and Folding Studies of SH2 and SH3 Domains

    • Julie D. Forman-Kay, Steven M. Pascal, Alex U. Singer, Toshio Yamazaki, Ouwen Zhang, Neil A. Farrow et al.
    Pages 35-47

  5. NMR Studies of Proteins Involved in Cell Adhesion Processes

    • Gerhard Wagner, Daniel F. Wyss, Johnathan S. Choi, Antonio R. N. Arulanandam, Ellis L. Reinherz, Andrzej Krezel et al.
    Pages 51-62

  6. Combining 2H and 13C Selective Enrichment to Probe Protein Dynamics

    • David M. LeMaster
    Pages 65-76

  7. Incorporating Motional Properties into the Interpretation of Three-dimensional Solution Structures

    • Walter J. Chazin
    Pages 77-86

  8. Phosphotyrosyl Peptide-Enzyme Complexes: How Much Structure Can We Get From Transferred Noe’s

    • Carol Beth Post, Michael L. Schneider
    Pages 91-99

  9. Panel Discussion

    • David Case, Marvin D. Kemple, N. Rama Krishna, Carol B. Post, Gerhard Wagner
    Pages 103-116

  10. Recent Developments in Protein NMR Spectroscopy

    • Stephan Grzesiek, Geerten W. Vuister, Andy C. Wang, Frank Delaglio, Ad Bax
    Pages 117-120

  11. Field-Cycling NMR Applied to Macromolecular Structure and Dynamics

    • Alfred G. Redfield
    Pages 123-132

  12. Cross-Correlations: Obstacles or Tools for Structure Determination of Biomolecules

    • Anil Kumar
    Pages 135-142

  13. Towards the Accurate Measurement of Internuclear Distances in Biological Macromolecules by Suppression of Spin Diffusion

    • Sébastien J. F. Vincent, Catherine Zwahlen, Geoffrey Bodenhausen
    Pages 145-164

  14. NMR of Symmetrical Assemblies of Self-Recognizing Oligonucleotides

    • Maurice Guéron, Kalle Gehring, Jean-Louis Leroy
    Pages 167-171

  15. Protein-DNA Interaction from NMR and Monte Carlo Docking

    • R. Kaptein, M. Slijper, V. P. Chuprina, J. A. C. Rullmann, R. M. A. Knegtel, R. Boelens
    Pages 175-187

  16. Dynamic Structure of Nucleic Acid Duplexes

    • Thomas L. James, Carlos González, He Liu, Uli Schmitz, Nikolai B. Ulyanov
    Pages 191-203

  17. Panel Discussion

    • G. Marius Clore, Stephen W. Fesik, David G. Gorenstein, David M. LeMaster, John L. Markley
    Pages 207-219

  18. NMR Structures of Proteins Involved in Signal Transduction

    • S. W. Fesik, R. P. Meadows, E. T. Olejniczak, A. P. Petros, P. J. Hajduk, H. S. Yoon et al.
    Pages 221-234

  19. Structures of Multimeric Proteins by NMR

    • G. Marius Clore, Angela M. Gronenborn
    Pages 237-242

  20. NMR Structural Studies of Flexible Molecules

    • Peter E. Wright, H. Jane Dyson
    Pages 245-249
Back to top

Keywords

About this book

The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon, and nitrogen nuclei in proteins of an earthbound 8rganism subtly orchestrating a quiet symphony of frequencies, from 150 Hz to 2 kHz, carrying clues to the three-dimensional structure of the macromolecules. The manner in which the basic discoveries of Bloch and Purcell have led to the emergence of NMR, several decades later, as a major technique of biological and medical physics (and chemistry) is a striking example of the power of basic research. It is also a fascinating saga whereby whenever it was felt that the field had reached a plateau, new directions, new technologies, and sometimes serendipity produced new developments that revolutionized the technique and enhanced its capability. As Richard Ernst points out "NMR is intellectually attractive, . . . the practical importance of NMR is enormous, and can justify much of the playful activities of an addicted spectroscopist" (Nobel lecture).

Editors and Affiliations

  • Indiana University-Purdue University, Indianapolis (IUPUI), Indianapolis, USA

    B. D. Nageswara Rao, Marvin D. Kemple

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation