Skip to main content
SpringerLink
Log in
Book cover

Detection of Mitochondrial Diseases

  • Book
  • © 1997

Overview

Editors:
  1. Frank Norbert Gellerich

    1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Stephan Zierz

    1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 21)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (50 chapters)

  1. Front Matter

    Pages i-3
    Download chapter PDF

  2. Noninvasive Detection of Mitochondrial Function

    1. Front Matter

      Pages 4-4
      Download chapter PDF

    2. Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry

      • William Bank, Britton Chance
      Pages 7-10

    3. In vivo assessment of human skeletal muscle mitochondria respiration in health and disease

      • Bruno Barbiroli, Stefano Iotti, Raffaele Lodi
      Pages 11-15

    4. Non-invasive quantitative 31P MRS assay of mitochondrial function in skeletal muscle in situ

      • Jeroen A. L. Jeneson, Robert W. Wiseman, Martin J. Kushmerick
      Pages 17-22

    5. Phosphorus metabolite distribution in skeletal muscle: Quantitative bioenergetics using creatine analogs

      • Robert W. Wiseman, M. J. Kushmerick
      Pages 23-28

    6. A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle

      • G. J. Kemp, D. N. Manners, J. F. Clark, M. E. Bastin, G. K. Radda
      Pages 29-32

    7. Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR

      • Ferdi A. van Dorsten, Torsten Reese, Johannes F. Gellerich, Cees J. A. van Echteld, Marcel G. J. Nederhoff, Henk-Jan Muller et al.
      Pages 33-42

    8. Experimental evidence for dynamic compartmentation of ADP at the mitochondrial periphery: Coupling of mitochondrial adenylate kinase and mitochondrial hexokinase with oxidative phosphorylation under conditions mimicking the intracellular colloid osmotic pressure

      • Fanny Dorine Laterveer, Klaas Nicolay, Frank Norbert Gellerich
      Pages 43-51

  3. Bioenergetic Investigation of Isolated Mitochondria, Skinned Muscle Fibers and Cells

    1. Front Matter

      Pages 53-53
      Download chapter PDF

    2. Small scale preparation of skeletal muscle mitochondria, criteria of integrity, and assays with reference to tissue function

      • Hans N. Rasmussen, Ulla F. Rasmussen
      Pages 55-60

    3. Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds

      • Hans R. Scholte, Yihong Yu, John D. Ross, Imma I. Oosterkamp, Adriana M. C. Boonman, F. M. Busch
      Pages 61-66

    4. Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria

      • Vida Mildaziene, Rasa Baniene, Ausra Marcinkeviciute, Zita Nauciene, Alvydas Kalvenas, Aurelijus Zimkus
      Pages 67-70

    5. High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders

      • Wolfgang Sperl, Daniela Skladal, Erich Gnaiger, Markus Wyss, Udo Mayr, Josef Hager et al.
      Pages 71-78

    6. Detection of early ischemic damage by analysis of mitochondrial function in skinned fibers

      • Laurence Kay, André Rossi, Valdur Saks
      Pages 79-85

    7. The effects of ischemia and experimental conditions on the respiration rate of cardiac fibers

      • Adolfas Toleikis, Daiva Majiene, Sonata Trumbeckaite, Arvydas Dagys
      Pages 87-90

    8. Insulin as a probe of mitochondrial metabolism in situ

      • Samuel P. Bessman, Chandra Mohan
      Pages 91-96

    9. Detection of mitochondrial defects by laser fluorimetry

      • Wolfram S. Kunz, Kirstin Winkler, Andrey V. Kuznetsov, Hartmut Lins, Elmar Kirches, Claus W. Wallesch
      Pages 97-100

    10. Oxidative phosphorylation in myocardial mitochondria ‘in situ’: a calorimetric study on permeabilized cardiac muscle preparations

      • Detlef Köhnke, Marion Schramm, Jürgen Daut
      Pages 101-113

    11. Nicotinamide adenine dinucleotides permeate through mitochondrial membranes in human Epstein-Barr virus-transformed lymphocytes

      • P. Rustin, D. Chretien, B. Parfait, A. Rötig, A. Munnich
      Pages 115-119
Back to top

Keywords

About this book

In October 1995, the 1st Colloquium on Mitochondria and Myopathies in Halle/Saale was organized in Halle/Saale by the editors of this focused issue. The meeting took up what might be called an East German tradition: from 1976 to 1990 Andreas Schmidt organized seven clinically orientated Colloquia on Myology in Jena, and from 1974 to 1990 a series of twelve Colloquia on Mitochondria focused on basic research aspects was arranged by Wolfgang Kunz in Magdeburg. At those meetings, East Germany was a mediator between East European, West European and American scientists. In continuation of this tradition, scientists from more than 17 countries working on mitochondria as neurologists, biochemists, geneticists, or as physiologists came to Halle. The title of the colloquium indicated the combination of both basic and clinical mitochondrial research. The most important contributions of this meeting are now published in this focused issue. We thank all authors for their patience and cooperation that have made it possible to produce this unique collection of papers representing current knowledge on detection of mitochondrial causes of diseases. We especially thank Prof. N.S. Dhalla for making it possible to publish these contributions together in this focused issue and also as a hard-cover book.

Editors and Affiliations

  • Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

    Frank Norbert Gellerich, Stephan Zierz

Bibliographic Information

  • Book Title: Detection of Mitochondrial Diseases

  • Editors: Frank Norbert Gellerich, Stephan Zierz

  • Series Title: Developments in Molecular and Cellular Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4615-6111-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1997

  • Hardcover ISBN: 978-0-7923-9925-4Published: 30 September 1997

  • Softcover ISBN: 978-1-4613-7800-6Published: 13 October 2012

  • eBook ISBN: 978-1-4615-6111-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VI, 341

  • Additional Information: Reprinted from MOLECULAR AND CELLULAR BIOCHEMISTRY, 174:1-2

  • Topics: Biochemistry, general

Publish with us

Policies and ethics

Back to top

Search

Navigation