Enzymology and Molecular Biology of Carbonyl Metabolism 6

1. Front Matter

   Pages i-xiv

   PDF

2. Crystal Structure of a Class 3 Aldehyde Dehydrogenase at 2.6Å Resolution

   • Zhi-Jie Liu, John Hempel, Julie Sun, John Rose, David Hsiao, Wen-Rui Chang et al.

   Pages 1-7

3. Conserved Residues in the Aldehyde Dehydrogenase Family

   • John Hempel, Zhi-Jie Liu, John Perozich, John Rose, Ronald Lindahl, Bi-Cheng Wang

   Pages 9-13

4. Class 3 Aldehyde Dehydrogenase

   • Ronald Lindahl, Yiqiang Xie, Josette S. Boesch, Keith Miskimins, Robin Miskimins

   Pages 15-18

5. Human Corneal and Lens Aldehyde Dehydrogenases

   • Gordon King, Roger Holmes

   Pages 19-27

6. Regulation of Rat ALDH-3 by Hepatic Protein Kinases and Glucocorticoids

   • Russell A. Prough, K. Cameron Falkner, Gong-Hua Xiao, Ronald G. Lindahl

   Pages 29-36

7. Mouse Dioxin-Inducible Ahd4 Gene

   • Vasilis Vasiliou, Steven F. Reuter, Te-Yen Shiao, Alvaro Puga, Daniel W. Nebert

   Pages 37-46

8. Changes in Aldehyde Dehydrogenase Isozymes Expression in Long-Term Cultures of Human Hematopoietic Progenitor Cells

   • Doris Meier-Tackmann, Dharam P. Agarwal, William Krueger, Caroline Dereskewitz, Hassan Tawhid Hassan, Alex Rolf Zander

   Pages 47-57

9. Expression of ALDH3 and NMO1 in Human Corneal Epithelial and Breast Adenocarcinoma Cells

   • Heather Marks-Hull, Te-Yen Shiao, Kaoru Araki-Sasaki, Robert Traver, Vasilis Vasiliou

   Pages 59-68

10. A Preliminary Report on the Cloning of a Constitutively Expressed Rat Liver Cytosolic ALDH cDNA by PCR

    • Eva C. Kathmann, James J. Lipsky

    Pages 69-72

11. Ontogenesis and Expression of ALDH Activity in the Skin and the Eye of the Rat

    • Perikles Pappas, Panayiotis Stephanou, Vasilis Vasiliou, Petros Karamanakos, Marios Marselos

    Pages 73-80

12. Class 1 and Class 3 Aldehyde Dehydrogenase Levels in the Human Tumor Cell Lines Currently Used by the National Cancer Institute to Screen for Potentially Useful Antitumor Agents

    • Lakshmaiah Sreerama, Norman E. Sladek

    Pages 81-94

13. Sex Differences in Endogenous Retinoid Release in the Post-Embryonic Spinal Cord of the Western Mosquitofish, Gambusia affinis affinis

    • E. Rosa-Molinar, P. J. McCaffery, B. Fritzsch

    Pages 95-108

14. Organ Distribution of Aldehyde Dehydrogenase Activity in the Newt

    • Harry E. Settles, Josette S. Boesch, Ronald G. Lindahl

    Pages 109-112

15. In Hepatoma Cell Lines Restored Lipid Peroxidation Affects Cell Viability Inversely to Aldehyde Metabolizing Enzyme Activity

    • Rosa A. Canuto, Margherita Ferro, Marina Maggiora, Rosanna Federa, Olga Brossa, Anna M. Bassi et al.

    Pages 113-122

16. Profiles of Hepatic Cellular Protein Adduction by Malondialdehyde and 4-Hydroxynonenal

    • Dylan P. Hartley, Dennis R. Petersen

    Pages 123-131

17. Inhibition of Human Class 3 Aldehyde Dehydrogenase, and Sensitization of Tumor Cells that Express Significant Amounts of this Enzyme to Oxazaphosphorines, by the Naturally Occurring Compound Gossypol

    • Ganaganur K. Rekha, Norman E. Sladek

    Pages 133-146

18. Aldehyde Dehydrogenase-Mediated Metabolism of Acetaldehyde and Mafosfamide in Blood of Healthy Subjects and Patients with Malignant Lymphoma

    • Melanie Metzenthin, Doris Meier-Tackmann, Dharam P. Agarwal, Reinhart Zschaber, Hans-Joseph Weh

    Pages 147-153

19. Yeast Aldehyde Dehydrogenase Sensitivity to Inhibition by Chlorpropamide Analogues as an Indicator of Human Aldehyde Dehydrogenase Sensitivity to These Agents

    • Varadahalli R. Devaraj, Lakshmaiah Sreerama, Melinda J. C. Lee, Herbert T. Nagasawa, Norman E. Sladek

    Pages 155-169

20. Laser Light Scattering and Ultracentrifuge Studies on Sheep Liver Cytosolic Aldehyde Dehdyrogenase

    • Jacqueline J. Harvey, Paul D. Buckley, James A. Lewis, Neil D. Pinder

    Pages 171-179

Since 1982, our ever-expanding group of investigators has been meeting in exotic parts of the world to discuss aspects of three enzyme systems. The 1996 meeting was no exception. Nearly 90 scientists from 15 countries met in the small city of Deadwood, South Dakota, for four days of stimulating talks and posters and incredible scenery. Once more this meeting reflected the changing trends in biochemical research. At the 1982 meeting most of the speakers discussed isolating new enzymes and trying to characterize them. At this meeting many speakers discussed interpretations of three-dimensional struc­ ture or regulatory elements of the genes controlling for the tissue-specific expression of the enzyme. Hopefully, readers will find the proceedings of the meeting to be of interest. Though they reflects the scientific information that was presented at the meeting, they do not indicate the level of personal interactions that went on during the meeting. Once again, the willingness of the participants to discuss unpublished data and to share thoughts about the future directions of their research helped make this, like our previous seven meetings, a special scientific experience for those who attended.

• Drogen
• biology
• enzyme
• enzymes
• enzymology
• genes
• metabolism
• molecular biology
• protein
• research
• steroids
• tissue

• Purdue University, West Lafayette, USA

  Henry Weiner

• University of South Dakota School of Medicine, Vermillion, USA

  Ronald Lindahl

• Indiana University School of Medicine, Indianapolis, USA

  David W. Crabb

• Queen’s University, Kingston, Canada

  T. Geoffrey Flynn

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