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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

  • Book
  • © 1998

Overview

Editors:
  1. Margaret M. McCarthy

    1. University of Maryland, Baltimore, USA

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Part of the book series: Perspectives in Antisense Science (DARE, volume 1)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
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  2. The Use of Antisense Technologies to Understand Neural Functioning: Fact or Fiction?

    • Margaret M. McCarthy
    Pages 1-8

  3. Tissue Distribution, Cellular Uptake, and Intracellular Localization and Stability of Centrally Administered Oligonucleotides in the Brain: Implications for Behavioral and Physiological Effects of Antisense Oligonucleotides

    • Wolfgang Sommer, Donald W. Pfaff, Sonoko Ogawa
    Pages 9-26

  4. Non-Specific Effects of Centrally Administered Oligonucleotides

    • Rainer Spanagel, Bernd Schöbitz, Mario Engelmann
    Pages 27-41

  5. Rapid Onset of Antisense Effects: Evidence for A Close Link Between Gene Expression and Neuronal Activity

    • Inga D. Neumann, Quentin J. Pittman
    Pages 43-59

  6. Effects of Dopamine Receptor Antisense RNA Expression Vectors in The Nervous System

    • Genoveva Davidkova, Sui-Po Zhang, Long-Wu Zhou, Benjamin Weiss
    Pages 61-82

  7. Modification of Native GABAA Receptor Assemblies Using Antisense Oligonucleotides

    • Dennis R. Grayson, Stephano Vicini
    Pages 83-101

  8. Antisense Oligodeoxynucleotides as Specific Tools for Studying Opioid Receptor-Mediated Analgesia

    • Leon F. Tseng
    Pages 103-124

  9. Antisense Approaches to Investigate the Neuroendocrine Control of Thirst and Sodium Appetite in The Rat

    • Randall R. Sakai, Li Yun Ma, Steven J. Fluharty
    Pages 125-140

  10. Steroid-Mediated Behaviors and Their Regulation by Antisense Oligodeoxynucleotides

    • Shailaja K. Mani, Pramod K. Dash
    Pages 141-157

  11. Modulation of Endocrine And Behavioral Rhythms with Antisense Oligonucleotides

    • Kathryn Scarbrough
    Pages 159-170

  12. Back Matter

    Pages 171-172
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Keywords

About this book

When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features:
  • experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors;
  • the novel use of plasmids to express antisense RNA in the nervous system;
  • the biodistribution and metabolism of antisense oligonucleotides in the nervous system;
  • rapid and unusual effects; and
  • non-specific effects.

Editors and Affiliations

  • University of Maryland, Baltimore, USA

    Margaret M. McCarthy

Bibliographic Information

  • Book Title: Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

  • Editors: Margaret M. McCarthy

  • Series Title: Perspectives in Antisense Science

  • DOI: https://doi.org/10.1007/978-1-4615-4933-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-7923-8242-3Published: 31 October 1998

  • Softcover ISBN: 978-1-4613-7238-7Published: 12 October 2012

  • eBook ISBN: 978-1-4615-4933-8Published: 06 December 2012

  • Series ISSN: 1566-0389

  • Edition Number: 1

  • Number of Pages: XI, 172

  • Topics: Neurosciences, Neurology, Biochemistry, general

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