Overview
- Editors:
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Barry P. Rosen
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Wayne State University, Detroit, USA
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Shahriar Mobashery
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Wayne State University, Detroit, USA
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Table of contents (14 chapters)
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- Didier Mazel, Julian Davies
Pages 1-6
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- Stuart B. Levy, Mark Nelson
Pages 17-25
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- Gerard D. Wright, Albert M. Berghuis, Shahriar Mobashery
Pages 27-69
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- Karen Bush, Shahriar Mobashery
Pages 71-98
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- Marc Ouellette, Éric Leblanc, Christoph Kündig, Barbara Papadopoulou
Pages 99-113
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- Luiz A. Basso, John S. Blanchard
Pages 115-144
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- Hendrik W. van Veen, Wil N. Konings
Pages 145-158
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- Rita Mukhopadhyay, Jiaxin Li, Hiranmoy Bhattacharjee, Barry P. Rosen
Pages 159-181
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- David J. C. Knowles, Frank King
Pages 183-195
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- Kenny K. Wong, David L. Pompliano
Pages 197-217
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- Michael R. Barbachyn, Steven J. Brickner, Robert C. Gadwood, Stuart A. Garmon, Kevin C. Grega, Douglas K. Hutchinson et al.
Pages 219-238
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- Paul M. Hershberger, Thomas P. Demuth Jr.
Pages 239-267
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- John M. Domagala, Diane Alessi, Maxwell Cummings, Stephen Gracheck, Liren Huang, Michael Huband et al.
Pages 269-286
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Back Matter
Pages 287-293
About this book
Antibiotic resistance, once a term appreciated only by microbiologists, has become a common topic in the popular press. Stuart Levy, one of the contributors to this collection, bears some of the responsibility for increasing public awareness with the publication of his book "The Antibiotic Paradox" in 1992: Misuse of antibiotics resulting in increased bacterial resistance had previously been recognized in the infectious disease community. However, Dr. Levy's eloquent public warning about the shrinking efficacy of our antibi otic armamentarium served to alert the lay person to the potential consequences of this de mise in useful therapy. Because of the proliferation of diverse antibiotic classes with increasing potency and broader activity spectra, it had been assumed that any ordinary bacterial infection could be eradicated with the proper selection of drug. However, it has become evident that we are surrounded by resistant bacteria, many of which were introduced unwittingly into our en vironment through the unnecessary use of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist ent ear infections or non-responsive bronchitis, questions were raised about the antibiotic treatments that were being prescribed. Bacteria resistant to common antibiotic regimens were being isolated more frequently, often as organisms classified as "multi-resistant" with decreased susceptibilities to two or more structural classes of agents. Nosocomial spread of these resistances was aided by the transmission of plasmid-mediated resistance factors between species.
