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Advances in DNA Damage and Repair

Oxygen Radical Effects, Cellular Protection, and Biological Consequences

  • Book
  • © 1999

Overview

Editors:
  1. Miral Dizdaroglu

    1. National Institute of Standards and Technology, Gaithersburg, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ali Esat Karakaya

    1. Gazi University, Ankara, Turkey

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 302)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Mapping Reactive Oxygen-Induced DNA Damage at Nucleotide Resolution

    • Steven Akman, Regen Drouin, Gerald Holmquist, Henry Rodriguez
    Pages 1-17

  3. Application of Oxidative DNA Damage Measurements to Study Antioxidant Actions of Dietary Components

    • Okezie I. Aruoma, Andrew Jenner, Barry Halliwell
    Pages 19-26

  4. DNA Repair and Transcription in Premature Aging Syndromes

    • Vilhelm A. Bohr, Adabalayam Balajee, Robert Brosh, Jan Nehlin, Amrita Machwe, Michele Evans et al.
    Pages 27-34

  5. Excision Repair of 8-Oxoguanine in Eukaryotes

    • Serge Boiteux, J. Pablo Radicella
    Pages 35-45

  6. Oxidative Base Damage to DNA

    • J. Cadet, M. Bardet, M. Berger, T. Berthod, T. Delatour, C. D’Ham et al.
    Pages 47-58

  7. Roles of AP Endonucleases in Repair and Genetic Stability

    • Bruce Demple, Elisabeth Bailey, Richard A. O. Bennett, Yuji Masuda, Donny Wong, Yong-jie Xu
    Pages 59-66

  8. Mechanisms of Oxidative DNA Damage; Lesions and Their Measurement

    • Miral Dizdaroglu
    Pages 67-87

  9. Drosophila Ribosomal Protein S3 Contains N-Glycosylase, Abasic Site, and Deoxyribophosphodiesterase DNA Repair Activities

    • Walter A. Deutsch
    Pages 89-96

  10. Bypass of DNA Damage by RNA Polymerases

    • Paul W. Doetsch, Anand Viswanathan, Wei Zhou, Jiang Liu
    Pages 97-110

  11. Saccharomyces Cerevisiae

    • Errol C. Friedberg, William J. Feaver, Wenya Huang, Michael S. Reagan, Simon H. Reed, Zhaoyang You et al.
    Pages 111-123

  12. Physiological Chemistry of Superoxide and Nitric Oxide Interactions

    • Matthew B. Grisham, David Jourd’heuil, David A. Wink
    Pages 125-134

  13. Recognition and Excision of Bases From Oxidatively Damaged DNA by Fpg, Oggl, and MutY Proteins

    • Arthur P. Grollman, Dmitry O. Zharkov
    Pages 135-148

  14. DNA Repair as A Susceptibility Factor in Chronic Diseases in Human Populations

    • Lawrence Grossman, Genevieve Matanoski, Evan Farmer, Mohammad Hedyati, Sugita Ray, Bruce Trock et al.
    Pages 149-167

  15. Transcription-Coupled DNA Repair

    • Philip C. Hanawalt, Graciela Spivak
    Pages 169-179

  16. Genotoxicity Tests

    • Ali E. Karakaya, Semra Sardas, Sema Burgaz
    Pages 181-191

  17. Studies on Oxidative Mechanisms of Metal-Induced Carcinogenesis

    • Kazimierz S. Kasprzak, Wojciech Bal, Dale W. Porter, Karol Bialkowski
    Pages 193-208

  18. Mechanism of Action of Escherichia coli Formamidopyrimidine N-Glycosylase and Endonuclease V

    • Yoke W. Kow, Lois E. Rabow
    Pages 209-219

  19. Human Uracil-DNA Glycosylase

    • Hans E. Krokan, Frank Skorpen, Marit Otterlei, Sangeeta Bharati, Kristin Steinsbekk, Hilde Nilsen et al.
    Pages 221-236

  20. Repair of DNA Damaged by Free Radicals

    • Jacques Laval, Cécile Bauche, Juan Jurado, Franck Paillard, Murat Saparbaev, Olga Sidorkina
    Pages 237-250
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Keywords

About this book

Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistence of human cells to DNA-damaging agents. This volume covers the most recent devlopments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology.

Editors and Affiliations

  • National Institute of Standards and Technology, Gaithersburg, USA

    Miral Dizdaroglu

  • Gazi University, Ankara, Turkey

    Ali Esat Karakaya

Bibliographic Information

  • Book Title: Advances in DNA Damage and Repair

  • Book Subtitle: Oxygen Radical Effects, Cellular Protection, and Biological Consequences

  • Editors: Miral Dizdaroglu, Ali Esat Karakaya

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4615-4865-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-306-46042-5Published: 28 February 1999

  • Softcover ISBN: 978-1-4613-7207-3Published: 09 November 2012

  • eBook ISBN: 978-1-4615-4865-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 511

  • Topics: Biochemistry, general, Human Genetics, Oncology, Immunology, Anatomy

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