Skip to main content
SpringerLink
Log in
Book cover

Copper Transport and Its Disorders

Molecular and Cellular Aspects

  • Book
  • © 1999

Overview

Editors:
  1. Arturo Leone

    1. University of Salerno, Salerno, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Julian F. B. Mercer

    1. The Murdoch Institute for Research into Birth Defects, Royal Children’s Hospital, Parkville, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 448)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (23 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Copper Transport in Mammals

    • Maria C. Linder, Norma A. Lomeli, Stephanie Donley, Farrokh Mehrbod, Philip Cerveza, Stephen Cotton et al.
    Pages 1-16

  3. Models to Evaluate Health Risks Derived from Copper Exposure/Intake in Humans

    • Manuel Olivares, Ricardo Uauy, Gloria Icaza, Mauricio González
    Pages 17-28

  4. Cu Metabolism in the Liver

    • Harry J. McArdle, Michelle J. Bingham, Karl Summer, T. J. Ong
    Pages 29-37

  5. Multiple Forms of the Menkes Cu-ATPase

    • Edward D. Harris, Manchi C. M. Reddy, Yongchang Qian, Evelyn Tiffany-Castiglioni, Sudeep Majumdar, John Nelson
    Pages 39-51

  6. The Cell Biology of the Menkes Disease Protein

    • Michael J. Petris, Julian F. B. Mercer, James Camakaris
    Pages 53-66

  7. Functional Analysis of the Menkes Protein (MNK) Expressed from a cDNA Construct

    • Sharon La Fontaine, Stephen D. Firth, Paul J. Lockhart, Hilary Brooks, James Camakaris, Julian F. B. Mercer
    Pages 67-82

  8. Mutation Spectrum of ATP7A, the Gene Defective in Menkes Disease

    • Zeynep TĂĽmer, Lisbeth Birk Møller, Nina Horn
    Pages 83-95

  9. Animal Models of Menkes Disease

    • Julian F. B. Mercer, Loreta Ambrosini, Sharon Horton, Sophie Gazeas, Andrew Grimes
    Pages 97-108

  10. Developmental Expression of the Mouse Mottled and Toxic Milk Genes

    • Yien-Ming Kuo, Jane Gitschier, Seymour Packman
    Pages 109-114

  11. The Treatment of Wilson&’s Disease

    • George J. Brewer
    Pages 115-126

  12. Indian Childhood Cirrhosis and Tyrolean Childhood Cirrhosis

    • M. S. Tanner
    Pages 127-137

  13. Animal Models of Wilson’s Disease

    • J. McC. Howell
    Pages 139-152

  14. Copper-Binding Properties of the N-Terminus of the Menkes Protein

    • Paul Cobine, Mark D. Harrison, Charles T. Dameron
    Pages 153-164

  15. Expression, Purification, and Metal Binding Characteristics of the Putative Copper Binding Domain from the Wilson Disease Copper Transporting ATPase (ATP7B)

    • Michael DiDonato, Suree Narindrasorasak, Bibudhendra Sarkar
    Pages 165-173

  16. Structure/Function Relationships in Ceruloplasmin

    • Giovanni Musci, Fabio Polticelli, Lilia Calabrese
    Pages 175-182

  17. Autoxidation of Amyloid Precursor Protein and Formation of Reactive Oxygen Species

    • G. Multhaup, L. Hesse, T. Borchardt, Thomas Ruppert, R. Cappai, C. L. Masters et al.
    Pages 183-192

  18. Copper-Zinc Superoxide Dismutase and ALS

    • Joan Selverstone Valentine, P. John Hart, Edith Butler Gralla
    Pages 193-203

  19. A Study of the Dual Role of Copper in Superoxide Dismutase as Antioxidant and Pro-Oxidant in Cellular Models of Amyotrophic Lateral Sclerosis

    • M. T. Carrì, A. Battistoni, A. Ferri, R. Gabbianelli, G. Rotilio
    Pages 205-213

  20. The Effect of Copper on Tight Junctional Permeability in a Human Intestinal Cell Line (Caco-2)

    • Simonetta Ferruzza, Yula Sambuy, Giuseppe Rotilio, Maria Rosa Ciriolo, Maria Laura Scarino
    Pages 215-222
Back to top

Keywords

About this book

This book is a compilation of presentations at the first meeting devoted to the mo­ lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ­ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met­ al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.

Editors and Affiliations

  • University of Salerno, Salerno, Italy

    Arturo Leone

  • The Murdoch Institute for Research into Birth Defects, Royal Children’s Hospital, Parkville, Australia

    Julian F. B. Mercer

Bibliographic Information

  • Book Title: Copper Transport and Its Disorders

  • Book Subtitle: Molecular and Cellular Aspects

  • Editors: Arturo Leone, Julian F. B. Mercer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-4859-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1999

  • Hardcover ISBN: 978-0-306-46045-6Published: 31 January 1999

  • Softcover ISBN: 978-1-4613-7204-2Published: 10 October 2012

  • eBook ISBN: 978-1-4615-4859-1Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 269

  • Topics: Biochemistry, general, Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation