Overview
- Editors:
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Basil Rapoport
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Autoimmune Disease Unit, Cedars-Sinai Research Institute and U.C.L.A. School of Medicine, Los Angeles, USA
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Sandra M. McLachlan
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Autoimmune Disease Unit, Cedars-Sinai Research Institute and U.C.L.A. School of Medicine, Los Angeles, USA
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Table of contents (21 chapters)
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Front Matter
Pages i-xiii
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- Robert Volpé, Clark Sawin
Pages 1-8
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- Yaron Tomer, Terry F. Davies
Pages 19-41
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- Basil Rapoport, Sandra M. McLachlan
Pages 43-66
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- Sandra M. McLachlan, Basil Rapoport
Pages 67-78
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- R. A. Ajjan, P. F. Watson, A. P. Weetman
Pages 79-93
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- Francesca Paolieri, Giampaola Pesce, Claudia Salmaso, Paola Montagna, Marcello Bagnasco
Pages 95-105
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- Peiqing Wu, James R. Baker Jr
Pages 107-126
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- Marian Ludgate, Sabine Costagliola, Gilbert Vassart
Pages 127-138
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- Michael M. Kaplan, Donald A. Meier
Pages 139-152
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- Milton D. Gross, John E. Freitas, James C. Sisson, B. Shapiro
Pages 153-167
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- Osamah Alsanea, Orlo H. Clark
Pages 169-183
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- Margita Zakarija, J. Maxwell McKenzie
Pages 215-226
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- Peter H. K. Eng, Lewis E. Braverman
Pages 235-247
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- Leonard Wartofsky, Matthew D. Ringel, Kenneth D. Burman
Pages 257-278
About this book
From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete.
The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease.
