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Regulatory Mechanisms in Breast Cancer

Advances in Cellular and Molecular Biology of Breast Cancer

  • Book
  • © 1991

Overview

Editors:
  1. Marc E. Lippman

    1. Lombardi Cancer Research Center, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Robert B. Dickson

    1. Lombardi Cancer Research Center, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Treatment and Research (CTAR, volume 53)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xii
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  2. Oncogenes, Antioncogenes, and Tumor Prognosis

    1. Front Matter

      Pages 1-1
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    2. Oncogenes as clinical prognostic indicators

      • Margaret C. Sunderland, William L. McGuire
      Pages 3-22

    3. Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma

      • Eva Y.-H. P. Lee, Rob Bookstein, Wen-Hwa Lee
      Pages 23-44

  3. Growth Factors and Their Receptors

    1. Front Matter

      Pages 45-45
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    2. Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland

      • David G. Fernig, John A. Smith, Philip S. Rudland
      Pages 47-78

    3. Local effects of growth factors

      • Charles W. Daniel, Gary B. Silberstein
      Pages 79-92

    4. The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer

      • Douglas Yee, Neal Rosen, Roberto E. Favoni, Kevin J. Cullen
      Pages 93-106

    5. The role of ras gene expression and transforming growth factor α production in the etiology and progression of rodent and human breast cancer

      • David S. Salomon, Fortunato Ciardiello, Eva M. Valverius, Nancy Kim
      Pages 107-157

    6. The role of epidermal growth factor receptors in breast cancer

      • Ronald N. Buick, Jorge Filmus, Jon G. Church
      Pages 159-170

    7. Cell proliferation in metazoans: Negative control mechanisms

      • Carlos Sonnenschein, Ana M. Soto
      Pages 171-194

  4. Estrogen and Antiestrogens

    1. Front Matter

      Pages 195-195
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    2. Steroid modulation of the expression of growth factors and oncogenes in breast cancer

      • K. S. McCarty Jr., K. S. McCarty Sr.
      Pages 197-220

    3. Antiestrogen therapy for breast cancer: Current strategies and potential causes for therapeutic failure

      • Y. Iino, D. F. C. Gibson, V. C. Jordan
      Pages 221-237

    4. Steroidal pure antiestrogens

      • Alan E. Wakeling
      Pages 239-257

    5. Estrogen-regulated messenger RNAs in human breast cancer cells

      • Bruce Westley, Felicity E. B. May
      Pages 259-271

    6. Estrogen and progesterone receptors

      • Mary Beth Martin, Miguel Saceda, Ralph K. Lindsey
      Pages 273-288

    7. Growth factors as mediators of estrogen/ antiestrogen action in human breast cancer cells

      • Carlos L. Arteaga, C. Kent Osborne
      Pages 289-304

    8. Steroids, growth factors, and cell cycle controls in breast cancer

      • Elizabeth A. Musgrove, Robert L. Sutherland
      Pages 305-331

  5. Stromal-Epithelial Interactions and Metastases

    1. Front Matter

      Pages 333-333
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Keywords

About this book

In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub­ lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres­ sion. In the two years since its publication, much new and exciting in­ formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho­ logists to establish prognostic outcome. Of particular interest is a new proto­ oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas­ toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto­ oncogene and antioncogene expression.

Reviews

This book is excellent in overall quality. The book is an important and useful addition to the scientific literature. It provides a fresh perspective on breast cancer for students and for clinical and basic researchers alike.Journal of the Nat. Cancer

Editors and Affiliations

  • Lombardi Cancer Research Center, USA

    Marc E. Lippman, Robert B. Dickson

Bibliographic Information

  • Book Title: Regulatory Mechanisms in Breast Cancer

  • Book Subtitle: Advances in Cellular and Molecular Biology of Breast Cancer

  • Editors: Marc E. Lippman, Robert B. Dickson

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4615-3940-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1991

  • Hardcover ISBN: 978-0-7923-0868-3Published: 31 January 1991

  • Softcover ISBN: 978-1-4613-6758-1Published: 21 October 2012

  • eBook ISBN: 978-1-4615-3940-7Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: IV, 452

  • Topics: Oncology, Cancer Research

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