Coagulation and Blood Transfusion

1. Front Matter

   Pages I-XIV

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2. Principles and Fundamentals

   1. Front Matter

      Pages 1-1

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   2. The Mechanisms of Thrombin Formation

      • H. C. Hemker, S. Béguin, T. Lindhout

      Pages 3-16

   3. Structure-Function Relationships of Human Coagulation Proteins

      • L. W. Hoyer

      Pages 17-28

   4. The Role of Calcium in Coagulation and Anticoagulation

      • M. E. Mikaelsson

      Pages 29-37

   5. Effect of Blood Collection on the Hemostatic Potential of Coagulation Proteins

      • R. Pflugshaupt, G. Kurt

      Pages 39-48

   6. Factor VIII Yields from Anticoagulant Exchanged Haemonetics Ultralite™ Plasma

      • J. Speak, A. M. Cumming, R. T. Wensley

      Pages 49-54

   7. Discussion

      • P. M. Mannucci, C. Th. Smit Sibinga

      Pages 55-63

3. Preservation Aspects

   1. Front Matter

      Pages 65-65

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   2. Platelet Function Preservation

      • S. Holme

      Pages 67-82

   3. Platelet Adhesion to the Vessel Wall

      • J. J. Sixma, Ph. G. de Groot

      Pages 83-91

   4. Trends in the Production and use of Coagulation Factor Concentrates

      • J. K. Smith

      Pages 93-101

   5. Immunoaffinity Purification of Factor VIII/von Willebrand Factor Complex

      • K. Koops, H. S. Hoff, J. J. van Weperen, P. C. Das, C. Th. Smit Sibinga

      Pages 103-117

   6. Structural and Functional Properties of Recombinant Coagulation Factors

      • A. Pavirani, S. Krishnan, S. Jallat, F. Perraud, A. Balland, W. Dalemans et al.

      Pages 119-124

   7. Discussion

      • L. W. Hoyer, P. C. Das

      Pages 125-134

4. Laboratory Aspects

   1. Front Matter

      Pages 135-135

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   2. Platelet Counting and Function Testing

      • B. Brozovic, R. L. McShine

      Pages 137-149

   3. The Predictive Value of Elisa Platelet Crossmatching for the Selection of Platelet Donors for Alloimmunized Patients

      • K. Sintnicolaas, W. Sizoo, R. L. H. Bolhuis

      Pages 151-158

   4. Clinical Efficacy of Platelet Concentrates

      • J. Th. M. de Wolf

      Pages 159-163

   5. Principles of Coagulation Factor Assays

      • A. M. H. P. van den Besselaar

      Pages 165-174

With great pleasure I welcome you to the City of Groningen. In more than one way there is cause for celebration. Today marks the third lustrum of the annual international sympo­ sium on blood transfusion, organized by the Rode Kruis Bloedbank Groningen-Drenthe. In my opinion it has been a remarkable initiative of the Bloedbank, to start organizing a scientific conference, as it did, in 1976. It meant, among others, that in case of success the initiative would grow to be an annual item on the international congress calen­ der. It also meant that a possible third lustrum would coincide with the celebration of the 950th anniversary of the City of Groningen. I am happy to note that the initiative has been successful: over the past fourteen years the Rode Kruis Bloedbank Groningen-Drenthe has succeeded in organizing an annual symposium on blood transfusion, with a different theme each year, and with an average attendance of 250 participants from some 26 countries world-wide. The platform created with the special formula of the symposium, for science and industry, has been well balanced and beneficial to both. Mr. Chairman, ladies and gentlemen, I like to compliment the organizers with the success that they have attained. Allow me to men­ tion the name of just one person, in whom I like to thank everyone who has been involved in creating the annual Bloedbank-symposia: my warm congratulations to Dr. Smit Sibinga and his staff.

• blood
• immune system
• plasma
• proteins
• transplantation

• Red Cross Blood Bank Groningen-Drenthe, The Netherlands

  C. Th. Smit Sibinga, P. C. Das

• Haemophila and Thrombosis Centre, Milan, Italy

  P. M. Mannucci

Policies and ethics