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Nitroarenes

Occurrence, Metabolism, and Biological Impact

  • Book
  • © 1990

Overview

Editors:
  1. Paul C. Howard

    1. Case Western Reserve University, Cleveland, USA

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  2. Stephen S. Hecht

    1. American Health Foundation, Valhalla, USA

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  3. Frederick A. Beland

    1. National Center for Toxicological Research, Jefferson, USA

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Part of the book series: Environmental Science Research (ESRH, volume 40)

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Epidemiology and Carcinogenesis

    1. Evidence from Animal Studies for the Carcinogenicity of Inhaled Diesel Exhaust

      • Joe L. Mauderly, William C. Griffith, Rogene F. Henderson, Robert K. Jones, Roger O. McClellan
      Pages 1-13

    2. Interpretation of Carcinogenicity and Effective Dose in Chronic Exposures of Rats to High Diesel Exhaust Concentrations

      • Werner Stöber
      Pages 15-27

    3. Carcinogenicity of Dinitroarenes in Rat Lung

      • Hiroshi Tokiwa, Kazumi Horikawa, Nobuyuki Sera, Keisuke Izumi, Masanori Iwagawa, Hisashi Otsuka et al.
      Pages 29-37

    4. In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-Pah’s, 2-Nitrofluorene

      • L. Möller, J. Rafter, S. Törnquist, L. Eriksson, B. Beije, R. ToftgÃ¥rd et al.
      Pages 39-59

  3. Chemistry, Detection, and Occurrence

    1. Nitroarenes: Their Detection, Mutagenicity and Occurrence in the Environment

      • Joellen Lewtas, Marcia G. Nishioka
      Pages 61-72

    2. The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air

      • Barbara Zielinska, Janet Arey, Roger Atkinson
      Pages 73-84

    3. Metabolism of 1-Nitropyrene Oxides and Effect of Nitrogen Dioxide on Arene Activation

      • Yoshinari Ohnishi, Takemi Kinouchi, Keiko Nishifuji, Koichi Miyanishi, Takako Kanoh, Masao Fukuda
      Pages 85-93

  4. Molecular Mechanisms

    1. Mutagenic and Biochemical Consequences of the Reaction of Arylamines with DNA

      • Charles M. King, Thomas M. Reid, Nobuya Tamura, Pawan K. Gupta
      Pages 95-103

    2. Mutagenesis Induced by a Single Acetylaminofluorene Adduct Within the NarI Site is Position Dependent

      • Patrice Koehl, Dominique Burnouf, Robert P. P. Fuchs
      Pages 105-112

    3. Unusual Hydrogen Bonding Patterns in 2-Aminofluorene (AF) and 2-Acetylaminofluorene (AAF) Modified DNA

      • S. Broyde, B. E. Hingerty, R. Shapiro, D. Norman
      Pages 113-123

    4. DNA Adduct Formation During Chronic Administration of an Aromatic Amine

      • Miriam C. Poirier, Nancy F. Fullerton, Henrik S. Huitfeldt, Beverly A. Smith, Henry C. Pitot, John M. Hunt et al.
      Pages 125-133

    5. Aerial Oxidation of Acetylaminofluorene-Derived DNA Adducts

      • Shinya Shibutani, Robert Gentles, Francis Johnson
      Pages 135-147

    6. Mutations and Homologous Recombination Induced by N-Substituted Aryl Compounds in Mammalian Cells

      • Veronica M. Maher, M. Chia-Miao Mah, Jia-Ling Yang, Nitai P. Bhattacharyya, J. Justin McCormick
      Pages 149-156

    7. Comparison of the Mutagenic Potency of DNA Adducts Formed by Reactive Derivatives of Aflatoxin, Benzidine and 1-Nitropyrene in a Plasmid System

      • Carl N. Martin, Gary S. Jennings
      Pages 157-166

    8. Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum

      • I. B. Lambert, A. J. E. Gordon, T. A. Chin, D. W. Bryant, B. W. Glickman, D. R. McCalla
      Pages 167-180

    9. DNA Adduct Formation by 1-Nitropyrene 4,5- and 9,10-Oxide

      • Beverly A. Smith, Robert H. Heflich, Yoshinari Ohnishi, Akinobu Ohuchida, Takemi Kinouchi, Janice R. Thorton-Manning et al.
      Pages 181-187

    10. Nitropolycyclic Aromatic Hydrocarbons and Diesel Exhaust: Potential Role of DNA Binding in Carcinogenicity

      • James A. Bond, Charles E. Mitchell, Joe L. Mauderly, Ronald K. Wolff
      Pages 189-199

    11. Validation/Application of 32P-Postlabeling Analysis for the Detection of DNA Adducts Resulting from Complex Air Pollution Sources Containing PAHs and Nitrated PAHs

      • J. E. Gallagher, M. J. Kohan, M. H. George, M. A. Jackson, J. Lewtas
      Pages 201-209

    12. Analysis of NO2-PAH DNA Adducts by Mass Spectrometry

      • Roger W. Giese, Paul Vouros
      Pages 211-217
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Keywords

About this book

Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.

Editors and Affiliations

  • Case Western Reserve University, Cleveland, USA

    Paul C. Howard

  • American Health Foundation, Valhalla, USA

    Stephen S. Hecht

  • National Center for Toxicological Research, Jefferson, USA

    Frederick A. Beland

Bibliographic Information

  • Book Title: Nitroarenes

  • Book Subtitle: Occurrence, Metabolism, and Biological Impact

  • Editors: Paul C. Howard, Stephen S. Hecht, Frederick A. Beland

  • Series Title: Environmental Science Research

  • DOI: https://doi.org/10.1007/978-1-4615-3800-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1990

  • Hardcover ISBN: 978-0-306-43694-9Published: 31 March 1991

  • Softcover ISBN: 978-1-4613-6694-2Published: 31 October 2012

  • eBook ISBN: 978-1-4615-3800-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: IX, 333

  • Topics: Biochemistry, general, Waste Management/Waste Technology, Ecotoxicology, Physical Chemistry

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