Skip to main content
SpringerLink
Log in

Recombinant Technology in Hemostasis and Thrombosis

  • Book
  • © 1991

Overview

Editors:
  1. Leon W. Hoyer

    1. Jerome H. Holland Laboratory, American Red Cross Blood Services, Rockville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. William N. Drohan

    1. Jerome H. Holland Laboratory, American Red Cross Blood Services, Rockville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Characterization of Gene and Protein Structure

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Biosynthesis and Assembly of the Factor VIII-Von Willebrand Factor Complex

      • Jan A. van Mourik, Anja Leyte, Harm B. van Schijndel, Martin Ph. Verbeet, Jan Voorberg, Ruud D. Fonteijn et al.
      Pages 3-12

    3. Factor IX: Gene Structure and Protein Synthesis

      • D. B. C. Ritchie, D. L. Robertson, R. T. A. MacGillivray
      Pages 13-24

    4. Antithrombin III Genetics, Structure and Function

      • Susan Clark Bock
      Pages 25-45

    5. Interactions Between The Functional Domains of Antithrombin III

      • Paula R. Boerger, Robert M. Wolcott, Morgan Lorio, Michael N. Blackburn
      Pages 47-63

    6. Protein C: Gene Structure and Protein Synthesis

      • George L. Long
      Pages 65-78

    7. Structural and Functional Properties of Protein C

      • Frederick J. Walker
      Pages 79-98

  3. Molecular Defects Affecting Hemostasis

    1. Front Matter

      Pages 99-99
      Download chapter PDF

    2. Molecular Defects in Hemophilia A

      • Leon W. Hoyer
      Pages 101-113

    3. Molecular Defects in Hemophilia B

      • Arthur R. Thompson
      Pages 115-131

    4. Molecular Defects in Human Antithrombin III Deficiency

      • W. P. Sheffield, F. Fernandez-Rachubinski, R. C. Austin, M. A. Blajchman
      Pages 133-146

    5. The Biologic Impact of Hereditary Defects that Cause Thrombosis

      • Kenneth A. Bauer
      Pages 147-167

  4. Protein Production by Recombinant Technology

    1. Front Matter

      Pages 169-169
      Download chapter PDF

    2. Factors Limiting Expression of Secreted Proteins in Mammalian Cells

      • Randal J. Kaufman, Robert J. Wise, Louise C. Wasley, Andrew J. Dorner
      Pages 171-185

    3. Synthesis of Biologically Active Vitamin K-Dependent Coagulation Factors

      • Barbara C. Furie, Bruce Furie
      Pages 187-195

    4. The Expression of Therapeutic Proteins in Transgenic Animals

      • Rekha Paleyanda, Janet Young, William Velander, William Drohan
      Pages 197-209

  5. Clinical Use of Proteins Produced by Recombinant Technology

    1. Front Matter

      Pages 211-211
      Download chapter PDF

    2. The Use of Animal Models to Evaluate Proteins Produced by Recombinant Technology

      • Alan R. Giles
      Pages 213-221

    3. Experiences with Recombinant Factor VIIa in Hemophiliacs

      • Ulla Hedner
      Pages 223-228
Back to top

Keywords

About this book

Recent progress in molecular biology has led to a rapid expansion of our understanding of the proteins that are essential for hemostasis and thrombosis. The goal of the XXI Annual Scientific Symposium of the American Red Cross was to provide a forum to explore and document the impact of recombinant DNA technology in this field. The speakers described the essential features of the genes responsible for key plasma proteins important in hemostasis, including procoagulant Factors VIII and IX and anticoagulant proteins, Antithrombin III and Protein C. They emphasized the advances in recombinant DNA technology that have led to the cloning of these genes. Careful examination of the gene sequence has then provided a clearer understanding of the structure of the encoded proteins, and has given additional insight into their functional domains and their interactions in hemostasis. At the same time, these advances have made it possible to better characterize hemostatic disorders. A large number of published studies have shown that the mutations affecting biological activity are clustered in areas that define functional domains. They have led to fundamental advances in our understanding of specific diseases and they have made it possible to develop more accurate and sensitive diagnostic tests for the detection of the disease states.

Editors and Affiliations

  • Jerome H. Holland Laboratory, American Red Cross Blood Services, Rockville, USA

    Leon W. Hoyer, William N. Drohan

Bibliographic Information

  • Book Title: Recombinant Technology in Hemostasis and Thrombosis

  • Editors: Leon W. Hoyer, William N. Drohan

  • DOI: https://doi.org/10.1007/978-1-4615-3698-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-306-43893-6Published: 31 May 1991

  • Softcover ISBN: 978-1-4613-6644-7Published: 18 October 2012

  • eBook ISBN: 978-1-4615-3698-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 261

  • Topics: Hematology, Biochemistry, general, Human Genetics, Animal Anatomy / Morphology / Histology, Plant Sciences

Publish with us

Policies and ethics

Back to top

Search

Navigation