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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury

Proceedings of the 2nd International Conference September 17–21, 1991 Berlin, FRG

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Santosh Nigam

    1. Department of Gynecological Endocrinology, Klinikum Steglitz, Free University Berlin, Berlin, Germany

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  2. Kenneth V. Honn

    1. Department of Radiation Oncology, Wayne State University, Detroit, USA

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  3. Lawrence J. Marnett

    1. Department of Biochemistry, Vanderbilt University, Nashville, USA

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  4. Thomas L. Walden

    1. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, USA

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Part of the book series: Developments in Oncology (DION, volume 71)

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Table of contents (151 papers)

  1. Front Matter

    Pages i-xlviii
    Download chapter PDF

  2. Enzymes Of Eicosanoid Biosynthesis

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Mutagenesis of Six Conserved Histidines in Human 5-Lipoxygenase, Effects on Enzyme Activity

      • Y. Zhang, O. Rådmark, B. Samuelsson
      Pages 3-6

    3. Arachidonate 12-Lipoxygenases: Enzymology and Molecular Biology

      • S. Yamamoto, T. Yoshimoto, N. Ueda, Y. Takahashi, S. Matsuda, H. Suzuki et al.
      Pages 7-10

    4. Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids

      • J. H. Capdevila, Y. Jin, A. Karara, J. R. Falck
      Pages 11-15

    5. The Significance of the Peroxide Tone in the Arachidonic Acid Cascade

      • V. Ullrich, G. Hecker, F. Meisch, M. Schatz-Munding
      Pages 17-21

    6. Properties and Functions of an Epidermal 8-Lipoxygenase

      • G. FüRstenberger, T. Jacobi, B. Schurich, M. LöSchke, W. D. Lehmann, M. Stephan et al.
      Pages 23-26

    7. On the Biological Role of Mammalian 15-Lipoxygenases

      • T. Schewe
      Pages 27-30

    8. Studies on Expression and Regulation of 5-Lipoxygenase in Human B Lymphocytes

      • P.-J Jakobsson, B. Odlander, D. Steinhilber, A. Rosen, H.-E Claesson, B. Samuelsson
      Pages 31-34

    9. Platelet-Activating Factor Induces Receptor Mediated Leukocyte 5 Lipoxygenase Activation Through its Translocation to the Membrane

      • J. Sola, L. Vila
      Pages 35-38

    10. Leukotriene A4 Hydrolase: A Zinc Metalloenzyme with Dual Enzymatic Activities

      • J. Z. HaeggstrÖM, A. Wetterholm, B. Samuelsson
      Pages 39-42

    11. Mutations of the Three Zinc-Ligands of Leukotriene A4 Hydrolase: Effects on Zinc Content and Enzyme Activities

      • J. F. Medina, A. Wetterholm, O. RåDmark, R. Shapiro, J. Z. HaeggströM, B. L. Vallee et al.
      Pages 43-46

    12. Effects of Anions on the Peptidase Activity of Leukotriene A4 Hydrolase

      • A. Wetterholm, J. Z. HaeggströM
      Pages 47-50

    13. ESR Investigation of Tyrosyl Radicals of Prostaglandin H Synthase; Relation to Enzyme Catalysis

      • G. Lassmann, R. Odenwaller, J. F. Curtis, J. A. Degray, R. P. Mason, L. J. Marnett et al.
      Pages 51-53

    14. Histidine Residues Involved in Heme Binding by Prostaglandin Endoperoxide Synthase

      • T. Shimokawa, W. L. Smith
      Pages 55-57

    15. Chemical Modifications of Prostaglandin Endoperoxide Synthase with N-Acetylimidazole and Tetranitromethane

      • H.-J. Scherer, R. Karthein, S. Strieder, H. H. Ruf
      Pages 59-62

    16. Rous Sarcoma Virus Induces a New Form of Prostaglandin G/H Synthase (Cyclooxygenase)

      • D. L. Simmons, W. Xie, G. E. Evett
      Pages 63-66

    17. 3-Hydroxy-5,8,11,14 (All CIS)-Eicosatetraenoic Acid (3-Hete) — A New Aspirin Sensitive Arachidonic Acid Metabolite from Yeast

      • M. S. Van Dyk, J. L. F. Kock, A. Botha, D. J. Coetzee, P. J. Botes, O. P. H. Augustyn et al.
      Pages 67-70

    18. Gestational Age Related Changes in Platelet Activating Factor Acetylhydrolase Activity in Maternal Plasma

      • N. M. Khan, S. A. Saeed
      Pages 71-74

    19. Phospholipid Hydroperoxide Glutathione Peroxidase: A Selenoprotein Distinct from Glutathione Peroxidase

      • R. Brigelius-Flohé, R. Schuckelt, W. StraβBurgher, F. Ursini, B. Wolf, I. L. Flohé
      Pages 75-78
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Keywords

About this book

In recent decades eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which the present volume represents the proceedings of the Second International Conference, held in Berlin in October 1991.

Editors and Affiliations

  • Department of Gynecological Endocrinology, Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  • Department of Radiation Oncology, Wayne State University, Detroit, USA

    Kenneth V. Honn

  • Department of Biochemistry, Vanderbilt University, Nashville, USA

    Lawrence J. Marnett

  • Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, USA

    Thomas L. Walden

Bibliographic Information

  • Book Title: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury

  • Book Subtitle: Proceedings of the 2nd International Conference September 17–21, 1991 Berlin, FRG

  • Editors: Santosh Nigam, Kenneth V. Honn, Lawrence J. Marnett, Thomas L. Walden

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4615-3520-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1993

  • Hardcover ISBN: 978-0-7923-1870-5Published: 31 August 1992

  • Softcover ISBN: 978-1-4613-6562-4Published: 06 November 2012

  • eBook ISBN: 978-1-4615-3520-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XLVIII, 799

  • Topics: Oncology, Diagnostic Radiology, Cancer Research

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