Genes, Oncogenes, and Hormones

1. Front Matter

   Pages i-xx

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2. The progression of node-negative to -positive breast cancer

   1. Front Matter

      Pages 1-1

      PDF

   2. Prognostic factors in axillary node-negative breast cancer

      • Richard M. Elledge, William L. McGuire

      Pages 3-19

   3. Role of type IV collagenases in human breast cancer

      • William G. Stetler-Stevenson, Lance A. Liotta, Peter D. Brown

      Pages 21-41

3. Suppressor genes and negative growth factors

   1. Front Matter

      Pages 43-43

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   2. Suppressor genes in breast cancer: An overview

      • Patricia S. Steeg

      Pages 45-57

   3. The role of the retinoblastoma gene in breast cancer development

      • Yuen Kai Fung, Anne T’Ang

      Pages 59-68

   4. Mammary-Derived Growth Inhibitor (MDGI)

      • Richard Grosse, Frank-D. Böhmer, Bert Binas, Andreas Kurtz, Eva Spitzer, Thomas Müller et al.

      Pages 69-96

   5. Roles for transforming growth factors-β in the genesis, prevention, and treatment of breast cancer

      • Lalage M. Wakefield, Anthony A. Colletta, Bryan K. McCune, Michael B. Sporn

      Pages 97-136

4. Oncogenes and stimulatory growth factors

   1. Front Matter

      Pages 137-137

      PDF

   2. Mechanisms involving an expanding erbB/EGF receptor family of tyrosine kinases in human neoplasia

      • Pier Paolo Di Fiore, Matthias H. Kraus

      Pages 139-160

   3. c-erb B2 amplification and overexpression in human tumors

      • Fiona J. Lofts, William J. Gullick

      Pages 161-179

   4. Clinical significance of erbB2 protein overexpression

      • Soonmyoung Paik, Elizabeth Burkhard, Marc E. Lippman

      Pages 181-191

   5. Anti-p185HER2 monoclonal antibodies: Biological properties and potential for immunotherapy

      • John W. Park, Robert Stagg, Gail D. Lewis, Paul Carter, Daniel Maneval, Dennis J. Slamon et al.

      Pages 193-211

   6. A chimeric EGFR/neu receptor in studies of neu function

      • Laura Lehtola, Heikki Lehväslaiho, Päivi Koskinen, Kari Alitalo

      Pages 213-228

   7. Involvement of protein kinase C in the growth regulation of human breast cancer cells

      • Doriano Fabbro, Willy Küng, Serban D. Costa, Christoph Borner, Urs Regenass, Urs Eppenberger

      Pages 229-248

   8. Tyrosine kinase receptor — nuclear protooncogene interactions in breast cancer

      • Robert B. Dickson, David S. Salomon, Marc E. Lippman

      Pages 249-273

5. Steroid hormone receptors

   1. Front Matter

      Pages 275-275

      PDF

   2. Characterization and regulation of estrogen and progesterone receptors in breast cancer

      • Linnea D. Read, Benita S. Katzenellenbogen

      Pages 277-299

   3. Estrogen and progesterone receptor structure and action in breast cancer cells

      • Saverio Bettuzzi, Alan Robinson, Robin Fuchs-Young, Geoffrey L. Greene

      Pages 301-315

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di­ agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

• biology
• development
• gene expression
• genes
• hormones
• immunotherapy
• metastasis
• molecular biology
• oncogene
• prevention
• protein
• tumor

• Lombardi Cancer Research Center, Georgetown University School of Medicine, USA

  Robert B. Dickson, Marc E. Lippman

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