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Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA — April 26–28, 1990

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Frederick A. Valeriote

    1. Wayne State University School of Medicine, Detroit, USA

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  2. Thomas H. Corbett

    1. Wayne State University School of Medicine, Detroit, USA

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  3. Laurence H. Baker

    1. Wayne State University School of Medicine, Detroit, USA

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Part of the book series: Developments in Oncology (DION, volume 68)

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Table of contents (23 papers)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Drug Discovery — 1990

    • Frederick Valeriote, Thomas Corbett, Laurence Baker
    Pages 1-9

  3. Data Display and Analysis Strategies for the NCI Disease-Oriented in Vitro Antitumor Drug Screen

    • M. R. Boyd, K. D. Paull, L. R. Rubinstein
    Pages 11-34

  4. Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay

    • Thomas H. Corbett, Frederick A. Valeriote, Lisa Polin, Chiab Panchapor, Susan Pugh, Kathryn White et al.
    Pages 35-87

  5. Thymidylate Synthase Inhibition of Modified Quinazoline Antifolates

    • A. J. Barker, L. R. Hughes, P. Warner, K. Burrows, A. L. Jackman
    Pages 89-103

  6. DNA-Minor Groove Binding Anticancer Agents

    • Wendell Wierenga
    Pages 105-122

  7. 2-((Arylmethyl)Amino)-1, 3-Propanediols (AMAPS); Discovery, Selection and Development of Four Clinical Candidates

    • Kenneth W. Bair
    Pages 123-147

  8. Mechanism-Based Approaches to Cancer Drug Discovery

    • Paul H. Fischer, Eric R. Larson, Robert L. Dow, Penny E. Miller
    Pages 149-157

  9. Discovery and Bulk Production of Natural Products with Anticancer Activity: The Role of Chemical Ecology

    • Matthew Suffness
    Pages 159-177

  10. Chemical Approaches to Improved Radiotherapy

    • W. R. Leopold, Judith S. Sebolt-Leopold
    Pages 179-196

  11. Large Scale Anticancer Drug Screening at Sterling Drug Inc.

    • Paul F. Cavanaugh Jr., Kenneth C. Mattes
    Pages 197-204

  12. Are Antisense Oligonucleotides Therapeutic Agents of the Future?

    • George S. Johnson
    Pages 205-214

  13. Supercomputer Aided Drug Design: Application in Oncology and AIDS

    • Frederick H. Hausheer, U. Chandra Singh, Jeffrey D. Saxe, Alexander L. Weis
    Pages 215-224

  14. Extrachromosomal DNA as a Target for Drug Development

    • Daniel D. Von Hoff
    Pages 225-236

  15. Prospective Evaluation of a Predictive Model for Plasma Concentration-Versus-Time Profiles of Investigational Anticancer Drugs in Patients

    • David S. Alberts, Denise J. Roe, Patricia M. Plezia, John G. Kuhn, Lisa E. Davis
    Pages 237-245

  16. Agent-Directed Preclinical Toxicology for New Antinfoplastic Drugs

    • Charles K. Grieshaber
    Pages 247-259

  17. Preclinical Studies with Brequinar Sodium: A Novel Anticancer Agent

    • Shih-Fong Chen, Daniel L. Dexter
    Pages 261-280

  18. Diphtheria Toxin-Related Peptide Hormone Fusion Proteins: New Toxins with Therapeutic Potential

    • John R. Murphy, Diane P. Williams, Tetsuyuki Kiyokawa, Paige L. Anderson, Terry B. Strom
    Pages 281-301

  19. Anti-Growth Factor Receptor Antibodies as Therapy for Cancer

    • Raymond Taetle
    Pages 303-323

  20. Regulation of Polyamine Biosynthetic Activity and Homeostasis as a Novel Antiproliferative Strategy

    • Carl W. Porter, Debora L. Kramer, Ralph J. Bernacki, Raymond J. Bergeron
    Pages 325-344
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Keywords

About this book

The focus of the 22nd Annual Detroit Cancer Symposium was the presentation and discussion of cytotoxic agents, with a significant portion of the symposium including the exciting frontiers of drug discovery being explored by the National Cooperative Drug Discovery Groups (NCDDG) Program. The symposium brought together a large number of investigators from government, universities and pharmaceutical companies involved in the discovery and development of new anticancer agents. Exciting new leads were presented and the status of others presently under development was discussed.
Of particular significance has been the initiation of renewed efforts in the area of natural product drug discovery, where the discovery of new cytotoxics is very promising at the moment. A number of major changes have occurred during the last decade in research on drug discovery of cytotoxic agents. Critical reviews of a number of the models and concepts underlying drug discovery represented a continuous thread throughout the meeting, being constantly discussed in terms of their advantages, disadvantages and capabilities of discovering solid tumor active anticancer agents.
A recent development which is to be much applauded and which portends to great discoveries is the new relationship formed between Government, University of Industry. The NCDDG mechanism which stimulates this interaction is an inexpensive manner to greatly magnify the drug discovery and development effort nationally. Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development represents a forum which will become the major mode for bringing together these three different components in the equation to regularly discuss new results and ideas.

Editors and Affiliations

  • Wayne State University School of Medicine, Detroit, USA

    Frederick A. Valeriote, Thomas H. Corbett, Laurence H. Baker

Bibliographic Information

  • Book Title: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

  • Book Subtitle: Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA — April 26–28, 1990

  • Editors: Frederick A. Valeriote, Thomas H. Corbett, Laurence H. Baker

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4615-3492-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-7923-1629-9Published: 31 March 1992

  • Softcover ISBN: 978-1-4613-6548-8Published: 08 October 2012

  • eBook ISBN: 978-1-4615-3492-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVII, 409

  • Topics: Oncology, Cancer Research

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