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The Role of Neurotransmitters in Brain Injury

  • Book
  • © 1992

Overview

Editors:
  1. Mordecai Y.-T. Globus

    1. University of Miami School of Medicine, Miami, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. W. Dalton Dietrich

    1. University of Miami School of Medicine, Miami, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (57 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Injury-Induced Release of Excitatory Amino Acids

    1. Front Matter

      Pages N1-N1
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    2. Excitatory Amino Acid Release Induced by Injury

      • Brian Meldrum, Maria H. Millan, Tihomir P. Obrenovitch
      Pages 1-7

    3. Excitatory Amino Acid Release After Focal Cerebral Ischaemia: Infarct Volume Determines EAA Release

      • Ross Bullock, Steven Butcher, David Graham, Graham Teasdale
      Pages 9-14

    4. A Pyrimidine Derivative, BW 1003C87, Decreases Glutamate Release and Protects Against Ischemic Damage

      • B. S. Meldrum, J. H. Swan, M. H. Millan, M. J. Leach, R. Gwinn, K. Kadota et al.
      Pages 15-20

    5. Pilocarpine-Induced Activation of In Vivo Aspartate and Glutamate Release in Dorsal Hippocampus

      • Maria H. Millan, Astrid G. Chapman, Brian S. Meldrum
      Pages 21-26

    6. Temperature Dependence of Glutamate Release During Transient Ischemia in the Gerbil and the Effecf of Repeated Occlusions

      • Nobuhito Saito, Thaddeus S. Nowak Jr., Igor Klatzo
      Pages 27-31

    7. Ischemia-Induced Neurotransmitter Release: Effects of Mild Intraischemic Hyperthermia

      • Linda L. Sternau, Mordecai Y.-T. Globus, W. Dalton Dietrich, Elena Martinez, Raul Busto, Myron D. Ginsberg
      Pages 33-38

    8. Glutamate Levels in Cerebrospinal Fluid: Do they Reflect In Vivo Modifications in Neurological Disorders?

      • Carlo Ferrarese, Nicoletta Pecora, Ildebrando Appollonio, Maura Frigo, Angelo Mamoli, Massimo Camerlingo et al.
      Pages 39-44

    9. Glutamale, Aspartate and Gaba Release from Hippocampal CA1 Slices During In Vitro Ischemia is Calcium-Independent

      • Stephan P. Burke, Charles P. Taylor
      Pages 45-49

    10. Glutamale Release and Calcium Influx Induced in Rat Neocortical Cultures by Reversal of Tile Transmembrane Sodium Gradient

      • Charles P. Taylor, Joann J. Geer, Stephen P. Burke
      Pages 51-56

    11. Topographical Dissociation of Calcium Accumulation Following Hypoxic-Hypoglycemic Glutamate Release, NMDA Receptor Concentration and Delayed Neuronal Death in Gerbil Hippocampus

      • Kiyoshi Kataoka, Akira Mitani, Fumito Kadoya, Yukio Yoneda, Kiyokazu Ogita, Riyo Enomoto
      Pages 57-61

  3. The Role of Glutamatergic Receptor in Brain Injury

    1. Front Matter

      Pages N2-N2
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    2. Dizocilpine (MK-801) in Cerebral Ischemia

      • Roland N. Auer
      Pages 63-69

    3. Protection by Two Non-NMDA Antagonists, NBQX and GYKI 52466 Against Selective Cell Loss following Transient Global Ischaemia (4VO) in the Rat

      • E. Le Peillet, B. Arvin, C. Moncada, B. S. Meldrum
      Pages 71-76

    4. Glutamate Neurotoxicity and Effect of Antagonists —In Vitro Study using Hippocampal Neurons Exposed to Hypoxia

      • Eiji Kohmura, Kazuo Yamada, Akira Kinoshita, Toru Hayakawa
      Pages 77-82

    5. Pharmacological Effects of Remacemide and MK-801 on Memory and Hippocampal CA1 Damage in the Rat Four-Vessel Occlusion (4-VO) Model of Global Ischemia

      • J. M. Ordy, B. Volpe, R. Murray, G. Thomas, P. Bialobok, T. M. Wengenack et al.
      Pages 83-92

    6. Comparative Effects of Magnesium Chloride and MK-801 on Infarct Volume after MCA Occlusion in Fischer-344 Rats

      • E. Pinard, Y. Izumi, S. Roussel, J. Seylaz
      Pages 93-98

    7. Generation and Propagation of Cortical Spreading Depression is Mediated by the NMDA Receptor

      • D. Scheller, U. Heister, F. Tegtmeier
      Pages 99-104

    8. Effects of Ketamine on Recovery of Auditory Brainstem Response after Total Brain Ischemia

      • Yasuhiko Kushida, Koujirou Hirota, Yutaka Yoshita, Kazuki Tohyama, Ken Yamamoto, Tsutomu Kobayashi et al.
      Pages 105-110
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Keywords

About this book

Neuroscientists from various disciplines have given extraordinary attention to the role of neurotransmitters in the field of neuronal injury. This volume summarizes the original oral and poster contributions which were presented at the symposium, "The Role of Neurotransmitters in Brain Injury," in Key West, Florida, between June 7-9, 1991. This symposium was the official Satellite of Brain-91, the Fifteenth International Symposium on Cerebral Blood Flow and Metabolism, held in Miami the previous week. The two principal goals of the Key West satellite meeting were to document recent progress and, more importantly, to explore future directions for investigative studies of the role of neurotransmitters in brain injury. To achieve these goals we assembled participants from diverse scientific fields and specialties who brought their collective expertise to discussions on the importance of neurotransmitters in neuronal and vascular injury following brain ischemia, trauma, and epilepsy. Their contributions are reflected in this volume. An important section of this volume is devoted to the role of glutamate and glutamatergic receptors in the development of ischemic neuronal damage. Topics covered include the mechanisms of glutamate and other excitatory amino acids, and the role of underlying injury-induced release different glutamatergic receptors in brain injury, including the NMDA and the non-NMDA receptors. The involvement of other neurotransmitters in the process of ischemic brain injury is well established.

Editors and Affiliations

  • University of Miami School of Medicine, Miami, USA

    Mordecai Y.-T. Globus, W. Dalton Dietrich

Bibliographic Information

  • Book Title: The Role of Neurotransmitters in Brain Injury

  • Editors: Mordecai Y.-T. Globus, W. Dalton Dietrich

  • DOI: https://doi.org/10.1007/978-1-4615-3452-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-306-44255-1Published: 31 December 1992

  • Softcover ISBN: 978-1-4613-6528-0Published: 05 November 2012

  • eBook ISBN: 978-1-4615-3452-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 378

  • Topics: Biochemistry, general, Animal Anatomy / Morphology / Histology, Plant Sciences, Neurosciences

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