Overview
- Editors:
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Chung K. Chu
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The University of Georgia, Athens, USA
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Horace G. Cutler
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Agricultural Research Service, United States Department of Agriculture, Athens, USA
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Table of contents (13 chapters)
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Front Matter
Pages i-viii
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- Mohamed Nasr, James Cradock, Margaret Johnston
Pages 31-56
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- Kirk R. Gustafson, John H. Cardellina II, Kirk P. Manfredi, John A. Beutler, James B. McMahon, Michael R. Boyd
Pages 57-67
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- Kuo-Hsiung Lee, Yoshiki Kashiwada, Gen-ichiro Nonaka, Itsuo Nishioka, Makoto Nishizawa, Takashi Yamagishi et al.
Pages 69-90
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- Daniel Meruelo, Steven Degar, Nuria Amari, Yehuda Mazur, David Lavie, Brandi Levin et al.
Pages 91-119
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- Bjarne Gabrielsen, Thomas P. Monath, John W. Huggins, Jorma J. Kirsi, Melinda Hollingshead, William M. Shannon et al.
Pages 121-135
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- Gary S. Jacob, Peter Scudder, Terry D. Butters, Ian Jones, David C. Tiemeier
Pages 137-152
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- Sylvia Lee-Huang, Hao-Chia Chen, Hsiang-fu Kung, Philip L. Huang, Peter L. Nara, Bao-Qun Li et al.
Pages 153-170
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- M. S. McGrath, K. C. Luk, H. D. Abrams, I. Gaston, S. Santulli, S. E. Caldwell et al.
Pages 171-193
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- Ghee T. Tan, John M. Pezzuto, A. Douglas Kinghorn
Pages 195-222
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- Daniel Lednicer, Ven L. Narayanan
Pages 223-238
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- Masahiro Tada, Kazuhiro Chiba, Takao Yoshii
Pages 239-255
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- Kazuhiro Irie, Koichi Koshimizu
Pages 257-273
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Back Matter
Pages 275-279
About this book
During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.
Editors and Affiliations
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The University of Georgia, Athens, USA
Chung K. Chu
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Agricultural Research Service, United States Department of Agriculture, Athens, USA
Horace G. Cutler