Leukemia: Advances in Research and Treatment

1. Front Matter

   Pages i-xv

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2. All trans retinoic acid as a targeting drug for differentiation therapy in acute promyelocytic leukemia

   • Laurent Degos

   Pages 1-13

3. Hairy cell leukemia: New understanding of biology and treatment

   • Alan Saven, Lawrence D. Piro, Carlos J. Carrera, Dennis A. Carson, Ernest Beutler

   Pages 15-34

4. Uses of polymerase chain reaction in leukemia: Detection of minimal residual disease and identification of novel genetic mutations

   • Ming-Sheng Lee, Sanford A. Stass

   Pages 35-44

5. The cell surface receptor encoded by the proto-oncogene KIT and its ligand

   • E. A. McCulloch, M. D. Minden

   Pages 45-77

6. Human T-cell lymphoma/leukemia retroviruses and malignancy

   • Michael P. Sherman, Dipak K. Dube, Nitin K. Saksena, Bernard J. Poiesz

   Pages 79-103

7. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia: Biology, clinical impact, and future directions

   • L. E. Robertson, Michael J. Keating

   Pages 105-119

8. The role of immunotherapy in the treatment of acute myeloblastic leukemia: from allogeneic bone marrow transplantation to the application of interleukin 2

   • H. Grant Prentice, Ian D. Macdonald, Michael D. Hamon

   Pages 121-134

9. Detection of minimal residual disease in ALL

   • Miriam Deane, A. Victor Hoffbrand

   Pages 135-170

10. Cytokines and myeloid-specific genes: Patterns of expression and possible role in proliferation and differentiation of acute myelogenous leukemia cells

    • Michael Lübbert, Roland Mertelsmann

    Pages 171-187

11. The immunological treatment of human marrow in vitro in transplantation biology

    • John G. Gribben, Lee M. Nadler

    Pages 189-211

12. Monoclonal antibodies in the treatment of myelogenous leukemias

    • David A. Scheinberg

    Pages 213-232

13. Prognosis and therapy of myelodysplastic syndromes

    • Elihu H. Estey

    Pages 233-267

14. Multidrug resistance in leukemia

    • Danny Rischin, Victor Ling

    Pages 269-293

15. The molecular pathogenesis of the philadelphia-positive leukemias: Implications for diagnosis and therapy

    • Richard A. Van Etten

    Pages 295-325

16. Back Matter

    Pages 327-336

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Leukemia continues to offer the scientist a unique opportunity to gain new knowledge about the malignant transformation. As a result, this multi-authored volume, devoted to advances which have occurred over the last seven years, provides the reader with an important new understanding of leukemia, but perhaps even more important, predicts analogous, new developments in the other malignant diagnoses. In this respect, this volume represents the cutting edge of cancer research. This text is unique in that it includes in a single volume the leading contributors to their respective fields covering what the editors feel are the major advances in our knowledge of the biology and therapy of leukemia over the last seven years.

• cell
• cytokines
• immunotherapy
• leukemia
• lymphoma
• pathogenesis
• transplantation

• M.D. Anderson Cancer Center, The University of Texas, USA

  Emil J. Freireich, Hagop Kantarjian

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