Skip to main content
SpringerLink
Log in
Book cover

Oncogene and Transgenics Correlates of Cancer Risk Assessments

  • Book
  • © 1992

Overview

Editors:
  1. Constantine Zervos

    1. Consulting in Health and Environmental Protection, Simpsonville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 232)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (23 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Cancer Risk Assessments: An Overview

    • Elizabeth L. Anderson
    Pages 1-20

  3. Pharmacodynamic Models for Cancer Risk Assessment

    • Suresh H. Moolgavkar
    Pages 21-29

  4. Predictive Value for Cancer Risk Assessment of Cell- and Tissue- Specific Formation of Carcinogen-DNA Adducts

    • Ewalt Scherer
    Pages 31-42

  5. Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation

    • Kevin R. O’Driscoll, Scott M. Kahn, Christoph M. Borner, Wei Jiang, I. Bernard Weinstein
    Pages 43-59

  6. Oncogene Activation and Human Cancer

    • Demetrios A. Spandidos, Margaret L. M. Anderson
    Pages 61-66

  7. Genetics of Hepatocarcinogenesis in Mouse and Man

    • Tommaso A. Dragani, Giacomo Manenti, Manuela Gariboldi, F. Stefania Falvella, Marco A. Pierotti, Giuseppe Della Porta
    Pages 67-80

  8. Protein Kinase C in Carcinogenesis: Comparative Expression of Oncogenes and Protein Kinase C in Rhabdomyosarcoma Models

    • Monique Castagna, Jacqueline Robert Lezenes, Xupei Huang, Nicole Hanania
    Pages 81-90

  9. Oncogenes and Human Cancers

    • J. S. Rhim, J. H. Yang, I. H. Lee, M. S. Lee, J. B. Park
    Pages 91-109

  10. ‘In Vivo’ Model Systems to Study ras Oncogene Involvement in Carcinogenesis

    • Ramon Mangues, Angel Pellicer
    Pages 111-126

  11. K-ras Oncogene Activation in Neoplasias of Patients with Familial Adenomatous Polyposis or Kidney Transplant

    • A. Haliassos, D. A. Spandidos
    Pages 127-131

  12. An Overview of Transgenic Mice as Future Models of Human Diseases, in Drug Development, and for Genotoxicity and Carcinogenesis Studies

    • J. C. Cordaro
    Pages 133-153

  13. Regulating Gene Expression in Mammalian Cell Culture and Transgenic Mice with Yeast GAL4/UAS Control Elements

    • David M. Ornitz, Radek Skoda, Randall W. Moreadith, Philip Leder
    Pages 155-172

  14. Genes and Oncogenes of the ras Superfamily

    • Armand Tavitian
    Pages 173-184

  15. Oncogenic Transgenic Mice in the Study of Carcinogenesis

    • Chang-Ho Ahn, Won-Chul Choi
    Pages 185-197

  16. Leukemia, Lymphoma, Embryonic Carcinoma and Hepatoma Induced in Transgenic Rabbits by the c-myc Oncogene Fused with Immunoglobulin Enhancers

    • Helga Spieker-Polet, Periannan Sethupathi, Herman Polet, Pi-Chen Yam, Katherine L. Knight
    Pages 199-216

  17. An Overview of the Outstanding Issues in the Risk Assessment of Methylene Chloride

    • Rory B. Conolly, Kannan Krishnan, Melvin E. Andersen
    Pages 217-229

  18. Cancer Dose-Response Modeling and Methylene Chloride

    • Gail Charnley
    Pages 231-240

  19. Risk Assessments for Benzene-Induced Leukemia — A Review

    • Kenny S. Crump
    Pages 241-262

  20. Comparative Metabolism and Genotoxicity Data on Benzene: Their Role in Cancer Risk Assessment

    • Sandro Grilli, Silvio Parodi, Maurizio Taningher, Annamaria Colacci
    Pages 263-291
Back to top

Keywords

About this book

The data, the information, and even the overarching knowledge necessary for risk assessments of economically important environmental carcinogens come, for the most part, from the applied biological disciplines, e. g. , toxicology, epidemiology, biostatistics, etc. The more fundamental biological disciplines, e. g. , biochemistry, cell biology, molecular biology, molecular genetics of cancer, etc. , have enormous but unrealized potential to improve current cancer risk assessment methods. The objective of this advanced research workshop ARW was to advance the state of the art of cancer risk assessment methods by identifying potential short and long term contributions to such methods from the more fundamental disciplines. Attention was paid to short and long term contributions from research advances in the biochemistry and physiology of oncogenes (oncogenes research) and in the construction and utilization of transgenic animals (transgenics research). In the last 20 years, researchers in the fundamental biological disciplines, i. e. , biochemists, geneticists, molecular and cell biologists, etc. , have, inter alia, advanced spectacularly our understanding of the nature of neoplastic diseases. Their phenomenal progress is the combined result of both advances and refinements of the techniques available to them and of new fundamental discoveries. Among the latter the most significant are the discoveries of oncogenes and of the feasibility of creating transgenic animals, i. e. , of transferring well defined and expressible genes from the cells of one species of organisms to the embryonic cells of another.

Editors and Affiliations

  • Consulting in Health and Environmental Protection, Simpsonville, USA

    Constantine Zervos

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation