Mechanisms of Platelet Activation and Control

1. Front Matter

   Pages i-xiv

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2. The Platelet as a Cа2+-Driven Cell: Mechanisms Which May Modulate Cа2+-Driven Responses

   • Michael C. Scrutton

   Pages 1-15

3. Agonist Receptors and G proteins as Mediators of Platelet Activation

   • Lawrence F. Brass, James A. Hoxie, Thomas Kieber-Emmons, David R. Manning, Mortimer Poncz, Marilyn Woolkalis

   Pages 17-36

4. Regulation of Phosphoinositide-Specific Phospholipase C Activity in Human Platelets

   • Yoshinori Nozawa, Yoshiko Banno, Koh-ichi Nagata

   Pages 37-47

5. RAP1B and Platelet Function

   • Eduardo G. Lapetina, Francis X. Farrell

   Pages 49-55

6. Calcium Signalling and Phosphoinositide Metabolism in Platelets: Subsecond Events Revealed by Quenched-Flow Techniques

   • Adrian R. L. Gear, Sanghamitra Raha

   Pages 57-67

7. Calcium Influx Mechanisms and Signal Organisation in Human Platelets

   • Stewart O. Sage, Paul Sargeant, Johan W. M. Heemskerk, Martyn P. Mahaut-Smith

   Pages 69-82

8. Ca2+ Homeostasis and Intracellular Pools in Human Platelets

   • Kalwant S. Authi

   Pages 83-104

9. The Use of Inhibitors of Protein Kinases and Protein Phosphatases to Investigate the Role of Protein Phоsphorylation in Platelet Activation

   • Steve P. Watson, Robert A. Blake, Trevor Lane, Trevor R. Walker

   Pages 105-118

10. Serine/Тhrеonine Kinases in Signal Transduction in Response to Thrombin in Human Platelets Use of 17—Hydroxywortmannin to Discriminate Signals

    • Kenneth J. Clemetson, Markus Kocher, Vinzenz von Tscharner

    Pages 119-128

11. Tyrosine Phosphorylation in Platelets: Its Regulation and Possible Roles in Platelet Functions

    • Maurice B. Feinstein, Kevin Pumiglia, Lit-Fui Lau

    Pages 129-148

12. Evidence That Activation of Phospholipase D can Mediate Secretion from Permeabilized Platelets

    • Richard J. Haslam, Jens R. Coorssen

    Pages 149-164

13. Inositol Lipid Metabolism, the Cytoskeleton, Glycoprotein IIb IIIa and Platelets

    • Gérard P. Mauco, Claire Sultan, Bernard Payrastre, Monique Plantavid, Monique Breton, Hugues Chap

    Pages 165-174

14. Regulation of Platelet Function by the Cytoskeleton

    • Joan E. B. Fox

    Pages 175-185

15. Cytoskeletal Interactions of Raplb in Platelets

    • Gilbert C. White II, Neville Crawford, Thomas H. Fischer

    Pages 187-194

16. Mechanisms Involved in Platelet Procoagulant Response

    • Edouard M. Bevers, Paul Comfurius, Robert F. A. Zwaal

    Pages 195-207

17. Histamine as an Intracellular Messenger in Human Platelets

    • J. M. Gerrard, S. P. Saxena, A. McNicol

    Pages 209-219

18. Platelet Activation Via Binding of Monoclonal Antibodies to the Fcγ Receptor II

    • J. Michael Wilkinson, Edward J. Hornby, Kalwant S. Authi

    Pages 221-228

19. Functional Relationship between Cyclic AMP-Dependent Protein Рhosphorylation and Platelet Inhibition

    • Wolfgang Siess, Bernd Grünberg, Karin Luber

    Pages 229-235

20. Role of Cyclic Nucleotide-Dependent Protein Kinases and Their Common Substrate VASP in the Regulation of Human Platelets

    • Ulrich Walter, Martin Eigenthaler, Jörg Geiger, Matthias Reinhard

    Pages 237-249

Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.

• Nucleotide
• protein
• proteins
• receptor
• research

• Thrombosis Research Institute, London, UK

  Kalwant S. Authi, Vijay V. Kakkar

• University of Oxford, Oxford, UK

  Steve P. Watson

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