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Antimutagenesis and Anticarcinogenesis Mechanisms III

  • Book
  • © 1993

Overview

Editors:
  1. Giorgio Bronzetti

    1. Istituto di Mutagenesi e Differenziamento del CNR, Pisa, Italy

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  2. Hikoya Hayatsu

    1. Okayama University, Okayama, Japan

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  3. Silvio Flora

    1. Istituto di Igiene e Medicina Preventia, Genova, Italy

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  4. Michael D. Waters

    1. U.S. Environmental Protection Agency, USA

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  5. Delbert M. Shankel

    1. University of Kansas, Lawrence, USA

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  6. Claire Wilson & Associates

    1. USA

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Part of the book series: Basic Life Sciences (BLSC, volume 61)

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Table of contents (41 chapters)

  1. Front Matter

    Pages i-xi
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  2. Mechanistic Approaches to Antimutagenesis and Anticarcinogenesis

    1. Mechanisms of Antimutagenesis and Anticarcinogenesis: Role in Primary Prevention

      • Silvio De Flora, Alberto Izzotti, Carlo Bennicelli
      Pages 1-16

    2. Multiple Mechanisms: The Example of Vitamin A

      • Luigi M. De Luca
      Pages 17-25

  3. Inhibition of Mutagenesis and Carcinogenesis by Extracellular Mechanisms

    1. Inhibition of Nitrosation

      • H. Bartsch, B. Pignatelli, S. Calmels, H. Ohshima
      Pages 27-44

    2. Protective Mechanisms of Dietary Fibers in Nutritional Carcinogenesis

      • John H. Weisburger, Bandaru S. Reddy, David P. Rose, Leonard A. Cohen, Marcia E. Kendall, Ernst L. Wynder
      Pages 45-63

    3. Extracellular Interception of Mutagens

      • D. M. Shankel, S. Kuo, C. Haines, L. A. Mitscher
      Pages 65-74

    4. Proteins as Scavengers of Nitrite: Antimutagenic Implications

      • Kiyomi Kikugawa, Tetsuta Kato
      Pages 75-85

    5. Antimutagenic Agents from Natural Products of Terrestrial and Marine Origin

      • Monroe E. Wall, Mansukh C. Wani
      Pages 87-97

    6. Inhibitory Effects of Dietary Leafy Vegetables on Mutagens and on Active Oxygens

      • Junko Ebata, Kazuaki Kawai, Hideyuki Furukawa
      Pages 99-102

    7. Extrapolation of in Vitro Antimutagenicity to the in Vivo Situation: The Case for Anthraflavic Acid

      • C. Ioannides, A. D. Ayrton, D. F. V. Lewis, R. Walker
      Pages 103-110

    8. Preventive Effect of Magnesium Hydroxide on Carcinogen-Induced Large Bowel Carcinogenesis in Rats

      • Hideki Mori, Yukio Morishita, Tukuro Shinoda, Takuji Tanaka
      Pages 111-118

    9. Antimutagenic Investigations on Commercial Yogurt

      • C. Della Croce, E. Morichetti, G. Bronzetti, C. Salvadori, E. Macri
      Pages 119-125

  4. Modulation of Metabolism and Blocking of Reactive Species

    1. Chemoprotection by Inducers of Electrophile Detoxication Enzymes

      • Thomas W. Kensler, Nancy E. Davidson, John D. Groopman, Bill D. Roebuck, Hans J. Prochaska, Paul Talalay
      Pages 127-136

    2. Protective Role of Glutathione, Thiols, and Analogues in Mutagenesis and Carcinogenesis

      • Bengt Jernström, Ralf Morgenstern, Peter Moldéus
      Pages 137-147

    3. N-Acetylcysteine Inhibits Diesel Extract Mutagenicity in the Ames Test and SCE Induction in Human Lymphocytes

      • R. Barale, R. Micheletti, C. Sbrana, I. Glussich, C. Scapoli, I. Barrai
      Pages 149-160

    4. Sulfotransferase- and Acetyltransferase-Mediated Activation of Carcinogenic N-Hydroxyarylamines in Mammals and Bacteria, and Their Modulation by Thiols

      • Yasushi Yamazoe, Medhat Abu-Zeid, Norma Staiano, Ryuichi Kato
      Pages 161-169

    5. Induction of Rat Liver GSH Transferases by 1,2-Dithiole-3-Thione Illustrates Both Anticarcinogenic and Tumor-Promoting Properties

      • David J. Meyer, Brian Coles, Jonathan Harris, Kim S. Gilmore, Kevin Raney, Thomas M. Harris et al.
      Pages 171-179

    6. Organ-Specific Modification of Carcinogenesis by Antioxidants in Rats

      • Masao Hirose, Tomoyuki Shirai, Satoru Takahashi, Kumiko Ogawa, Nobuyuki Ito
      Pages 181-188

    7. The Modulating Effects of Antioxidants in Rat Embryos and Sertoli Cells in Culture

      • Diana Anderson, Anne J. Francis
      Pages 189-200

    8. Blocking the Plant Activation of Promutagenic Aromatic Amines by Peroxidase Inhibitors

      • Michael J. Plewa
      Pages 201-217
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Keywords

About this book

Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.

Editors and Affiliations

  • Istituto di Mutagenesi e Differenziamento del CNR, Pisa, Italy

    Giorgio Bronzetti

  • Okayama University, Okayama, Japan

    Hikoya Hayatsu

  • Istituto di Igiene e Medicina Preventia, Genova, Italy

    Silvio Flora

  • U.S. Environmental Protection Agency, USA

    Michael D. Waters

  • University of Kansas, Lawrence, USA

    Delbert M. Shankel

  • USA

    Claire Wilson & Associates

Bibliographic Information

  • Book Title: Antimutagenesis and Anticarcinogenesis Mechanisms III

  • Editors: Giorgio Bronzetti, Hikoya Hayatsu, Silvio Flora, Michael D. Waters, Delbert M. Shankel, Claire Wilson & Associates

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4615-2984-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Hardcover ISBN: 978-0-306-44577-4Published: 30 November 1993

  • Softcover ISBN: 978-1-4613-6299-9Published: 02 November 2012

  • eBook ISBN: 978-1-4615-2984-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 494

  • Topics: Pharmacology/Toxicology, Human Genetics

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