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Interactive Phenomena in the Cardiac System

  • Book
  • © 1993

Overview

Editors:
  1. Samuel Sideman

    1. Technion-Israel Institute of Technology, Haifa, Israel

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    You can also search for this editor in PubMed   Google Scholar

  2. Rafael Beyar

    1. Technion-Israel Institute of Technology, Haifa, Israel

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 346)

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Cell to Organ: Electromechanical Activation

    1. Front Matter

      Pages 1-1
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    2. Regulation of Intracellular Calcium in Cardiac Muscle

      • Peter H. Backx, Wei Dong Gao, Michelle D. Azan-Backx, Eduardo Marban
      Pages 3-10

    3. Neuromodulation of Calcium Current by Extracellular ATP in Isolated Ventricular Myocytes

      • Yusheng Qu, Donald L. Campbell, Herbert H. Himmel, Harold C. Strauss
      Pages 11-18

    4. Intracellular Calcium and Myocardial Function During Ischemia

      • David G. Allen, Simeon P. Cairns, Stuart E. Turvey, John A. Lee
      Pages 19-29

    5. Intracellular Signaling in Vascular Smooth Muscle

      • Avril V. Somlyo, Andrew P. Somlyo
      Pages 31-38

    6. Myocardial Energetics

      • Lincoln E. Ford
      Pages 39-49

    7. Mechanisms of Endocardial Endothelium Modulation of Myocardial Performance

      • Stanislas U. Sys, Luc J. Andries, Thierry C. Gillebert, Dirk L. Brutsaert
      Pages 51-58

    8. Calcium Kinetic and Mechanical Regulation of the Cardiac Muscle

      • Amir Landesberg, Samuel Sideman
      Pages 59-77

    9. Cellular Responses to Electrical Stimulation: A Study Using a Model of the Ventricular Cardiac Action Potential

      • Yoram Rudy, Ching-hsing Luo
      Pages 79-90

    10. Excitation-Contraction Coupling and Contractile Protein Function in Failing and Nonfailing Human Myocardium

      • Gerd Hasenfuss, Burkert Pieske, Christian Holubarsch, Norman R. Alpert, Hanjörg Just
      Pages 91-100

  3. Mechanics and Microcirculation

    1. Front Matter

      Pages 101-101
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    2. Estimation of Myocardial Mechanical Properties with Dynamic Transverse Stiffness

      • Henry R. Halperin, Joshua E. Tsitlik, Barry K. Rayburn, Jon R. Resar, Julie Z. Livingston, Frank C. P. Yin
      Pages 103-112

    3. Intramyocardial Mechanical States: Vessel-Interstitium-Muscle Interface

      • J. Yasha Kresh
      Pages 113-123

    4. Myocardial Mechanics and Coronary Flow Dynamics

      • Rafael Beyar, Dan Manor, Samuel Sideman
      Pages 125-136

    5. Modeling of Coronary Capillary Flow

      • Gadi Fibich, Yoram Lanir, Nadav Liron, Mark Abovsky
      Pages 137-150

  4. Microstructure: Mechanics and Microcirculation

    1. Front Matter

      Pages 151-151
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    2. Models for Coronary Pressure-Flow Relationships

      • Robert E. Mates, Robert M. Judd
      Pages 153-161

    3. In Vivo Myocardial Microcirculation: Evaluation with a Whole-Body X-Ray CT Method

      • Erik L. Ritman
      Pages 163-171

    4. Endocardial Coronary Microcirculation of the Beating Heart

      • Fumihiko Kajiya, Toyotaka Yada, Akihiro Kimura, Osamu Hiramatsu, Masami Goto, Yasuo Ogasawara et al.
      Pages 173-180
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Keywords

About this book

The cardiac system represents one of the most exciting challenges to human ingenuity. Critical to our survival, it consists of a tantalizing array of interacting phenomena, from ionic transport, membrane channels and receptors through cellular metabolism, energy production to fiber mechanics, microcirculation, electrical activation to the global, clinically observed, function, which is measured by pressure, volume, coronary flow, heart rate, shape changes and responds to imposed loads and pharmaceutical challenges. It is a complex interdisciplinary system requiring the joint efforts of the life sciences, the exact sciences, engineering and technology to understand and control the pathologies involved. The Henry Goldberg Workshops were set up to address these multivariable, multidisciplinary challenges. Briefly, our goals are: To encourage international cooperation and foster interdisciplinary interaction between scientists from the different areas of cardiology; to relate microscale cellular phenomena to the global, clinically manifested cardiac function; to relate conceptual modeling and quantitative analysis to experimental and clinical data; to gain an integrated view of the various interacting parameters, identify missing links, catalyze new questions, and lead to better understanding of the cardiac system. The outstanding success of past workshops has encouraged their continuation. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects.

Editors and Affiliations

  • Technion-Israel Institute of Technology, Haifa, Israel

    Samuel Sideman, Rafael Beyar

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