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Biological Effects and Physics of Solar and Galactic Cosmic Radiation

Part A

  • Book
  • © 1993

Overview

Editors:
  1. Charles E. Swenberg

    1. Armed Forces Radiobiology Research Institute, Bethesda, USA
      Complexity Incorporated, Potomac, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gerda Horneck

    1. DLR Institute of Aerospace Medicine, Cologne, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. E. G. Stassinopoulos

    1. NASA-Goddard Space Flight Center, Greenbelt, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 243A)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Radiation Effects on Biological Systems

    1. Radiation-Induced DNA Lesions in Eukaryotic Cells, Their Repair and Biological Relevance

      • M. Frankenberg-Schwager
      Pages 1-31

    2. Assessment of Heavy Ion Induced DNA Strand Breaks in Mammalian Cells

      • J. Heilmann, H. Rink
      Pages 33-36

    3. Does the Topology of Closed Supercoiled DNA Affect its Radiation Sensitivity?

      • C. E. Swenberg, J. M. Speicher, J. H. Miller
      Pages 37-47

    4. Plasmids as Testsystem for the Detection of DNA Strand Breaks

      • J. Wehner, G. Horneck, H. Bücker
      Pages 49-52

    5. High Resolution Gel Electrophoresis Methods for Studying Sequence-Dependence of Radiation Damage and Effects of Radioprotectants in Deoxyoligonucleotides

      • B. Mao, C. E. Swenberg, Y. Vaishnav, N. E. Geacintov
      Pages 53-61

    6. Thymine Dimer Formation Mediated by the Photosensitizing Properties of Pharmaceutical Constituents

      • L. F. Salter, B. S. Martincigh, K. Bolton, S. R. Aliwell, S. J. Clemmett
      Pages 63-70

    7. The Assay of 2’ Deoxyuridine-3’-Monophosphate (dUMP) by 3’ Phosphorylation and Two Dimensional Thin Layer Chromatography: A Potential Radiation Marker of DNA Damage

      • Antonio Cajigas, J. J. Steinberg
      Pages 71-83

    8. Free-Radical Yields in Proton Irradiation of Oriented DNA: Relationship to Energy Transfer Along DNA Chains

      • J. H. Miller, D. L. Frasco, M. Ye, C. E. Swenberg, L. S. Myers Jr., A. Rupprecht
      Pages 85-91

    9. Free Radical Formation in Amino Acids Induced by Heavy Ions

      • T. Heck, J. Hüttermann, G. Kraft
      Pages 93-98

    10. The Biostack Concept and Its Application in Space and at Accelerators: Studies on Bacillus Subtilis Spores

      • G. Horneck
      Pages 99-115

    11. Biological Action of Single Heavy Ions on Individual Yeast Cells

      • Michael Kost, Jürgen Kiefer
      Pages 117-123

    12. Repair of Radiation Induced Genetic Damage Under Microgravity: An Experimental Proposal

      • H.-D. Pross, M. Kost, J. Kiefer
      Pages 125-128

    13. DNA Damage Repair and Mutagenesis in Mutants of Escherichia Coli

      • S. I. Ahmad
      Pages 129-134

    14. Neoplastic Transformation Induced by Heavy Ions: Studies on Transformation Efficiencies and Molecular Mechanisms

      • Ludwig Hieber, Jan Smida, Albrecht M. Kellerer
      Pages 135-141

    15. On the Mechanism and Consequences of Radiation-Induced Gene Amplification in Mammalian Cells

      • Christine Lücke-Huhle
      Pages 143-154

    16. Alteration in Lipid Peroxidation in Plant Cells after Accelerated Ion Irradiation

      • A. Vasilenko, S. Zhadko, P. G. Sidorenko
      Pages 155-159

    17. Tumour Induction in Animals and the Radiation Risk for Man

      • J. J. Broerse, J. Davelaar, C. Zurcher
      Pages 161-175

    18. Progress in the Extrapolation of Radiation Cataractogenesis Data Across Longer-Lived Mammalian Species

      • A. B. Cox, Y. L. Salmon, A. C. Lee, J. T. Lett, G. R. Williams, J. J. Broerse et al.
      Pages 177-184

    19. Effects of Linear Energy Transfer on the Formation and Fate of Radiation Damage to the Photoreceptor Cell Complement of the Rabbit Retina: Implications for the Projected Manned Mission to Mars

      • J. T. Lett, G. R. Williams
      Pages 185-201
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Keywords

About this book

Space missions subject human beings or any other target of a spacecraft to a radiation environment of an intensity and composition not available on earth. Whereas for missions in low earth orbit (LEO), such as those using the Space Shuttle or Space Station scenario, radiation exposure guidelines have been developed and have been adopted by spacefaring agencies, for exploratory class missions that will take the space travellers outside the protective confines of the geomagnetic field sufficient guidelines for radiation protection are still outstanding. For a piloted Mars mission, the whole concept of radiation protection needs to be reconsidered. Since there is an increasing interest ci many nations and space agencies in establishing a lunar base and lor exploring Mars by manned missions, it is both, timely and important to develop appropriate risk estimates and radiation protection guidelines which will have an influence on the design and structure of space vehicles and habitation areas of the extraterrestrial settlements. This book is the result of a multidisciplinary effort to assess the state of art in our knowledge on the radiation situation during deep space missions and on the impact of this complex radiation environment on the space traveller. ]t comprises the lectures by the faculty members as well as short contributions by the students given at the NATO Advanced Study Institute "Biological Effects and Physics of Solar and Galactic Cosmic Radiation" held in Armacao de Pera, Portugal, 12-23 October, 1991.

Editors and Affiliations

  • Armed Forces Radiobiology Research Institute, Bethesda, USA

    Charles E. Swenberg

  • Complexity Incorporated, Potomac, USA

    Charles E. Swenberg

  • DLR Institute of Aerospace Medicine, Cologne, Germany

    Gerda Horneck

  • NASA-Goddard Space Flight Center, Greenbelt, USA

    E. G. Stassinopoulos

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