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Protease Inhibitors as Cancer Chemopreventive Agents

  • Book
  • © 1993

Overview

Editors:
  1. Walter Troll

    1. Department of Environmental Medicine, New York University Medical Center, New York, USA

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  2. Ann R. Kennedy

    1. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xviii
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  2. The Epidemiologic Approach to the Study of Protease Inhibitors

    • Elizabeth Fontham, Pelayo Correa
    Pages 1-8

  3. Anticarcinogenic Activity of Protease Inhibitors Overview

    • Ann R. Kennedy
    Pages 9-64

  4. In Vitro Studies of Anticarcinogenic Protease Inhibitors

    • Ann R. Kennedy
    Pages 65-91

  5. Discovery and Background of the Bowman-Birk Protease Inhibitors

    • Donald E. Bowman
    Pages 93-96

  6. Protease Inhibitors of Plant Origin and Role of Protease Inhibitors in Human Nutrition Overview

    • Yehudith Birk
    Pages 97-106

  7. Antigenicity of Soybean Protease Inhibitors

    • David L. Brandon, Anne H. Bates, Mendel Friedman
    Pages 107-129

  8. Low-Molecular-Weight Protease Inhibitors of Microbial Origin

    • Kazuo Umezawa, Takaaki Aoyagi, Wataru Tanaka, Tomio Takeuchi
    Pages 131-139

  9. Protease Inhibitor Synthesis by MCF-7 Breast Cancer Cells

    • Thomas H. Finlay, Susan S. Kadner, Snait Tamir
    Pages 141-159

  10. Analysis of Structure-Activity Relationships of the Bowman-Birk Inhibitor of Serine Proteinases

    • Peter Flecker
    Pages 161-176

  11. Prevention of Cancer by Vitamin B3 (Nicotinamide and Nicotinic Acid)

    • Walter Troll
    Pages 177-189

  12. Approaches to Studying the Target Enzymes of Anticarcinogenic Protease Inhibitors

    • Paul C. Billings
    Pages 191-198

  13. Anticarcinogenic Activities of Naturally Occurring Cysteine Proteinase Inhibitors

    • Rita Colella, Ann F. Chambers, David T. Denhardt
    Pages 199-216

  14. Cell Membrane Enzymes Containing Chymotrypsin-like Activity

    • Jonathan Yavelow, Lorraine T. Schepis, Joseph Nickels Jr., George Ritchie
    Pages 217-225

  15. The Role of Reactive Oxygen Species in Biological Damage and the Effect of Some Chemopreventive Agents

    • Krystyna Frenkel
    Pages 227-249

  16. Protease Inhibitor Suppression of ras Oncogene-Induced Transformation

    • Seymour J. Garte, Lydia Cox, Diane C. Currie, Joan Motz, Walter Troll
    Pages 251-263

  17. Suppression of c-myc by Anticarcinogenic Protease Inhibitors

    • Janice D. Chang, Ann R. Kennedy
    Pages 265-280

  18. A Role for Esterases in Steroid Hormone Turnover

    • Mortimer Levitz, Sila Banerjee, Joseph Katz, Uma Raju, Thomas H. Finlay
    Pages 281-293

  19. Protease Inhibitors and Pancreatic Carcinogenesis

    • B. D. Roebuck, Daniel S. Longnecker
    Pages 295-303

  20. Back Matter

    Pages 305-315
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Keywords

About this book

Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.

Editors and Affiliations

  • Department of Environmental Medicine, New York University Medical Center, New York, USA

    Walter Troll

  • Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, USA

    Ann R. Kennedy

Bibliographic Information

  • Book Title: Protease Inhibitors as Cancer Chemopreventive Agents

  • Editors: Walter Troll, Ann R. Kennedy

  • DOI: https://doi.org/10.1007/978-1-4615-2882-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Hardcover ISBN: 978-0-306-44390-9Published: 31 July 1993

  • Softcover ISBN: 978-1-4613-6249-4Published: 25 October 2012

  • eBook ISBN: 978-1-4615-2882-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 315

  • Topics: Oncology, Biochemistry, general

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