Diastolic Relaxation of the Heart

1. Front Matter

   Pages i-xiii

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2. Molecular Biology of Relaxation

   1. Front Matter

      Pages 1-1

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   2. Overview: The Molecular Phenotype of Normal and Impaired Relaxation

      • Ketty Schwartz, Kenneth R. Boheler

      Pages 3-6

   3. Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Program

      • Arthur M. Feldman, Vinnette T. Edwards, Jennifer E. Lawrence, Randall E. Williams, Warren D. Rosenblum

      Pages 7-16

   4. Sarcoplasmic Reticulum Gene Expression in Human Heart Failure

      • Muthu Periasamy, Masashi Arai

      Pages 17-23

   5. Molecular Aspects of the Control of Myocardial Relaxation

      • Ichiro Shiojima, Issei Komuro, Tsutomu Yamazaki, Ryozo Nagai, Yoshio Yazaki

      Pages 25-32

   6. Molecular Physiology of Ventricular Hypertrophy

      • Kenneth R. Chien

      Pages 33-40

3. Consequences of Altered Gene Expression: The Economy of Diastole

   1. Front Matter

      Pages 41-41

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   2. Regulatory Proteins and Diastolic Relaxation

      • R. John Solaro, Beata M. Wolska, Margaret Westfall

      Pages 43-53

   3. Intracellular Free Calcium in Hypertrophy and Failure

      • Judith K. Gwathmey, Ronglih Liao, Roger J. Hajjar

      Pages 55-64

   4. A Molecular Biophysical Approach to Contraction and Relaxation

      • Norman R. Alpert, Jon N. Peterson

      Pages 65-71

   5. On the Relations among ATP Hydrolysis, Cation Accumulation, and Diastolic Dysfunction

      • Monique Bernard, Stefan Neubauer, Joanne S. Ingwall

      Pages 73-78

   6. Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastole

      • James D. Marsh

      Pages 79-90

   7. Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failure

      • Beverly H. Lorell

      Pages 91-99

   8. Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart: Relevance of SR-Ca2+-ATPase Protein Levels

      • Gerd Hasenfuss, Hans Reinecke, Roland Studer, Helmut Drexler, Burkert Pieske, Christian Holubarsch et al.

      Pages 101-108

4. Impaired Relaxation in Experimental Models: Ischemia AIVD Hypoxia

   1. Front Matter

      Pages 109-109

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   2. Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Model

      • James P. Morgan, Kazumasa Harada, Achim Meissner, Christian Williams, Joseph P. Carrozza, Lisa A. Bentivegna et al.

      Pages 111-123

   3. Diastolic Dysfunction During Ischemia: Role of Glycolytic ATP Generation

      • Carl S. Apstein

      Pages 125-134

   4. Does Calcium Overload Adequately Explain Diastolic Dysfunction During Metabolic Inhibition?

      • William H. Barry, Hiroshi Ikenouchi

      Pages 135-148

   5. Mechanisms of Relaxation: Perspectives from Studies in Single Cardiac Cells

      • Edward G. Lakatta, Steven J. Sollott, Andrzej M. Janczewski, Giovanni Gambassi, Howard S. Silverman, Maurizio C. Capogrossi et al.

      Pages 149-165

Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease.
This brand new Second Edition, based on a recent meeting, includes such topics as:

• molecular biology of relaxation;
• consequences of altered gene expression;
• impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure);
• diastolic dysfunction in the diseased human heart.

Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function.

• heart
• heart disease
• heart failure
• hypertension
• physiology

• Harvard Medical School, USA

  Beverly H. Lorell, William Grossman

• Hemodynamic Research Laboratory, Beth Israel Hospital, Boston, USA

  Beverly H. Lorell

• Cardiovascular Division, Beth Israel Hospital, Boston, USA

  William Grossman

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