Progress in Iron Research

1. Front Matter

   Pages i-ix

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2. Biophysical Aspects of Iron Compounds

   1. Mechanism of Fe(II) Oxidation and Core Formation in Ferritin

      • P. M. Harrison, E. R. Bauminger, D. Hechel, N. W. Hodson, I. Nowik, A. Treffry et al.

      Pages 1-12

   2. Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin

      • Paolo Arosio, Alberto Albertini, Sonia Levi, Paolo Santambrogio, Anna Cozzi, Barbara Corsi et al.

      Pages 13-21

   3. Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins

      • N. Dennis Chasteen, Shujun Sun, Sonia Levi, Paolo Arosio

      Pages 23-30

3. Transferrin and Transferrin Receptor Physiology

   1. The Transferrin Receptor and the Release of Iron from Transferrin

      • Philip Aisen

      Pages 31-40

   2. The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages

      • Erwin Regoeczi, Wei-Li Hu, Paul A. Chindemi, Maria Janicka

      Pages 41-50

   3. Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition

      • G. de Jong, W. L. van Noort, H. G. van Eijk

      Pages 51-59

   4. Mechanism of Production of the Serum Transferrin Receptor

      • Roy D. Baynes, Yuan J. Shih, James D. Cook

      Pages 61-68

4. Iron Absorption and Uptake

   1. Iron Absorption and Cellular Uptake of Iron

      • Marcel E. Conrad, Jay N. Umbreit, Elizabeth G. Moore

      Pages 69-79

   2. Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts

      • Gregory J. Anderson, Andrew Dancis, Dragos G. Roman, Richard D. Klausner

      Pages 81-89

   3. Cellular Responses to Iron and Iron Compounds

      • Jeremy H. Brock, Abdelhakim Djeha, Maznah Ismail, Rosa Oria, Richard H. Sinclair

      Pages 91-100

   4. The Structure and Function of Iron Regulatory Factor

      • Lukas C. Kühn, Harald Hirling, Beric Henderson, Alice Emery-Goodman, Barbara Neupert, Pierre Kaldy

      Pages 101-109

   5. Structure and Function of Ires, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase

      • Elizabeth C. Theil, R. Ann McKenzie, Hanna Sierzputowska-Gracz

      Pages 111-118

   6. Translational Control by Iron-Responsive Elements

      • Matthias W. Hentze

      Pages 119-126

   7. The Role of Cytokines in the Regulation of Ferritin Expression

      • Jack Rogers, Linda Lacroix, Gerald Durmowitz, Kristen Kasschau, James Andriotakis, Kenneth R. Bridges

      Pages 127-132

   8. Stimulation of IRE-BP Activity of IRF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase

      • Günter Weiss, Kurt Grünewald, Kostas Pantopoulos, Britta Goossen, Matthias W. Hentze, Wolfgang Doppler et al.

      Pages 133-139

   9. Reciprocal Modulation of Aconitase Activity and RNA-Binding Activity of Iron Regulatory Factor by Nitric Oxide

      • Jean-Claude Drapier, Juana Wietzerbin, Harald Hirling, Pierre Kaldy, Lukas C. Kühn

      Pages 141-148

5. Ferritin Metabolism

   1. A New Look at Ferritin Metabolism

      • J W Halliday, G A Ramm, D Moss, L W Powell

      Pages 149-156

   2. Bacterioferritin: A Hemoprotein Member of the Ferritin Family

      • Edward I. Stiefel, Matthew J. Grossman, Stephen M. Hinton, Vera Minak-Bernero, Roger C. Prince, Richard E. Bare et al.

      Pages 157-164

6. Erythroid iron Regulation

   1. Intracellular Iron

      • Simeon Pollack

      Pages 165-171

The 4th International Conference on Hemochromatosis and the 11th International Conference on Iron and Iron Proteins took place in Jerusalem on April 27 -30 and on May 2 -7 1993, respectively. The first, a clinical meeting, and the second, a forum designed primarily for basic scientists. Both meetings are held regularly on alter­ nate years and represent probably the most important forum for the exchange of information in iron research. The present volume "Progress in Iron Research" is based on a selection of presentations delivered at these meetings. However, this volume represents much more than a publication of conference proceedings. It offers a comprehensive state-of-the-art review on most aspects of iron metabolism. We have tried to offer a balanced review of the most important recent developments in iron research including both basic research and clinical investigation. However, the scope of chapters was based, by definition, on the actual participants at the meetings and some important fields in iron research such as plant physiology, microbial aspects of iron metabolism, and free radical research have not been dealt with. Many of the authors of the 40 chapters have beel). pt1rsonally responsible for some of the most important developments in iron research ~~vidffig: n~~~ights into iron physiology and pathophysiology. The Editors wish to express their gratitude for the outstanding and timely cooperation of all contributors to this volume.

• development
• metabolism
• pathophysiology
• physiology
• plant physiology
• protein

• Shaare Zedek Medical Center and Hebrew University of Jerusalem, Jerusalem, Israel

  Chaim Hershko

• The Hebrew University Hadassah Medical School, Jerusalem, Israel

  Abraham M. Konijn

• Albert Einstein College of Medicine, Bronx, USA

  Philip Aisen

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