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The Cell Cycle

Regulators, Targets, and Clinical Applications

  • Book
  • © 1994

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Editors:
  1. Valerie W. Hu

    1. The George Washington University Medical Center, USA

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Table of contents (48 chapters)

  1. Front Matter

    Pages i-xi
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  2. Regulators of the Cell Cycle

    1. Front Matter

      Pages 1-1
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    2. Protein Phosphorylation and the Regulation of Key Events in Oocyte and Egg Cell Cycles

      • James L. Maller
      Pages 3-15

    3. Control of G1 Progression by Mammalian D-Type Cyclins

      • Charles J. Sherr, Hitoshi Matsushime, Jun-ya Kato, Dawn E. Quelle, Martine F. Roussel
      Pages 17-23

    4. Phosphorylation in the Regulation of Protein Phosphatases

      • David L. Brautigan, Jian Chen, Fran Pinault, Jeremy Somers, Richard Zimmerman
      Pages 25-32

    5. Positive and Negative Regulation of Cell Cycle Progression by Serine/Threonine Protein Phosphatases

      • Arthur S. Alberts, Axel Schönthal
      Pages 33-40

    6. Effects of Phosphatase Inhibitors on Mammalian p34cdc2 Kinase Activities

      • Xiao-Wen Guo, John P. H. Th’ng, Richard A. Swank, E. Morton Bradbury
      Pages 41-49

    7. The Meiotic Role of twine, A Drosophila Homologue of cdc25

      • Luke Alphey, Helen White-Cooper, David Glover
      Pages 51-57

  3. Control of Cell Proliferation

    1. Front Matter

      Pages 59-59
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    2. Extracellular Signal-Regulated Protein Kinases (ERKS) 1, 2, and 3

      • David J. Robbins, Erzhen Zhen, Mangeng Cheng, Colleen A. Vanderbilt, Douglas Ebert, Clark Garcia et al.
      Pages 61-66

    3. Cell Cycle Traverse and Growth Arrest Control in Senescent Human Fibroblasts

      • Eugenia Wang, Menq-Jer Lee
      Pages 67-78

    4. Cellular Senescence and the Cell Cycle

      • J. Carl Barrett, Cynthia A. Afshari
      Pages 79-89

    5. Cell Cycle Targets of Viral Oncoproteins

      • Joseph R. Nevins
      Pages 91-97

    6. A GTPase Cycle Coupled to the Cell Cycle

      • Elias Coutavas, Mindong Ren, Joel D. Oppenheim, Vijay Yajnik, Peter D’Eustachio, Mark G. Rush
      Pages 99-110

    7. Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth

      • Sarah Spiegel
      Pages 111-119

  4. Cell Cycle Control of Gene Expression and Repair

    1. Front Matter

      Pages 121-121
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    2. Histone Gene Transcription During the Cell Cycle

      • Franca LaBella, Rosanna Martinelli, Neil Segil, Nathaniel Heintz
      Pages 123-125

    3. G1-S Regulatory Promoter Elements and their Interacting Transcription Factors

      • Gregory S. Naeve, Li-jing Li, Lin Guo, Ajay Sharma, Amy S. Lee
      Pages 127-139

    4. Regulation of Thymidylate Synthase Gene Expression in Growth-Stimulated Cells

      • Lee F. Johnson
      Pages 141-147

    5. The Role of the Transcription Factor E2F in the Growth Regulation of DHFR

      • Jill E. Slansky, Peggy J. Farnham
      Pages 149-154
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Keywords

About this book

Interest in the cell cycle has grown explosively in recent years as a result of the identification of key cell cycle regulators and their substrates. Aside from enhancing our understanding of normal cellular growth controls, this new knowledge has also becn valuable in elucidating mechanisms of growth deregulation which occur in diseased states, such as cancer and, in some instances, viral or parasitic infections. The Thirteenth Washington International Spring Symposium was organized with the intention of bringing together scientists working on different aspects of the cell cycle. Scientific topics presented ranged from molecular regulators and effectors to mitosis­ specific changes in cell architecture to the role of the cell cycle in development and disease. The goal of this gathering was to help formulate a more comprehensive and integrated picture of events driving and being driven by the cell cycle, as well as to evaluate the possibilities for clinical application of this knowledge. This symposium, held in Washington, D.C. from May 10-14, 1993, was attended by more than 400 scientists from 20 countries, including many of the scientific leaders in this field. This volume contains most of the papers presented at the seven plenary sessions in addition to selected contributions from a total of nine special oral and poster sessions.

Editors and Affiliations

  • The George Washington University Medical Center, USA

    Valerie W. Hu

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