Signal Transduction Mechanisms

1. Front Matter

   Pages i-1

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2. Protein engineering and NMR studies of calmodulin

   • Hans J. Vogel, Mingjie Zhang

   Pages 3-15

3. PEST sequences in calmodulin-binding proteins

   • Junor A. Barnes, Aldrin V. Gomes

   Pages 17-27

4. High molecular weight calmodulin-binding protein is phosphorylated by calmodulin-dependent protein kinase VI from bovine cardiac muscle

   • Shigeo Taketa, Junor A. Barnes, Mandeep Ubhi, Rajendra K. Sharma

   Pages 29-34

5. Regulatory properties of neuronal cdc2-like kinase

   • Zhong Qi, Damu Tang, Isao Matsuura, Ki-Young Lee, Xujing Zhu, Qi-Quan Huang et al.

   Pages 35-39

6. Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C

   • Alastair Aitken, Steve Howell, David Jones, Joel Madrazo, Harry Martin, Yasmina Patel et al.

   Pages 41-49

7. Modulation of protein kinase C by adenosine: Involvement of adenosine A1 receptor-pertussis toxin sensitive nucleotide binding protein system

   • Ravi B. Marala, S. Jamal Mustafa

   Pages 51-58

8. Phosphorylation and partial sequence of pregnant sheep myometrium myosin light chain kinase

   • Mary D. Pato, Ewa Kerc, Stephen J. Lye

   Pages 59-69

9. Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart

   • Tonia C. Carter, Haldane G. Coore

   Pages 71-75

10. Tyrosine kinase-mediated signal transduction pathways and the actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle

    • Morley D. Hollenberg

    Pages 77-85

11. Protein tyrosine phosphorylation in cardiovascular system

    • Ashok K. Srivastava

    Pages 87-94

12. Regulation of glycogen synthase activation in isolated hepatocytes

    • Subbiah Pugazhenthi, Ramji L. Khandelwal

    Pages 95-101

13. Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: roles of cyclic nucleotides, calcium, protein kinases and phosphatases and depolarization

    • Prakash V. Sulakhe, Xuan T. Vo

    Pages 103-126

14. Preliminary crystallization studies of calmodulin- dependent protein phosphatase (calcineurin) from bovine brain

    • K. Balendiran, Yingchun Tan, Rajendra K. Sharma, Krishna H. M. Murthy

    Pages 127-130

15. Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney

    • Brian N. Cockburn, Haldane G. Coore

    Pages 131-136

16. Subcellular calcium oscillators and calcium influx support agonist-induced calcium waves in cultured astrocytes

    • Sergey Yagodin, Lynne A. Holtzclaw, James T. Russell

    Pages 137-144

17. Activation and deactivation of sarcoplasmic reticulum calcium release channels: Molecular dissection of mechanisms via novel semi-synthetic ryanoids

    • Keshore R. Bidasee, Henry R. Besch Jr., Koert Gerzon, Rod A. Humerickhouse

    Pages 145-160

18. Inositol lipid-mediated signalling in response to endothelin and ATP in the mammalian testis

    • Simon A. Rudge, Phillip J. Hughes, Graham R. Brown, Robert H. Michell, Christopher J. Kirk

    Pages 161-174

19. Second messenger role of magnesium in pancreatic acinar cells of the rat

    • Jaipaul Singh, Denham M. Wisdom

    Pages 175-182

20. Evidence for multisite ADP-ribosylation of neuronal phosphoprotein B-50/GAP-43

    • Keith Philibert, Henk Zwiers

    Pages 183-190

This volume contains the proceedings of an International Symposium on `Second Messenger Systems - Molecular, Cellular and Behavioural Aspects', which was held at Tobago on June 16-17, 1994.
The interaction of an extracellular agonist (First Messenger) with its plasma membrane receptor leads to the transmission of a signal across the cell membrane and results in the production and/or activation of other signalling molecules (Second Messengers). These Second Messengers control the action of many protein kinases and protein phosphatases and so lead to cellular responses. Although the biochemical basis of the transduction of signals in the main signalling systems in eukaryotic cells is probably largely known, intensified research is ongoing in the following areas: the discovery of specific substrates for many protein kinases, elucidation of the biological significance of the differential tissue expression and heterogeneity of many signalling proteins, and the unravelling of diverse interactions (such as signal potentiation, synergism, antagonism and neuronal co-transmission) between signalling systems. As knowledge from such studies accumulates, it is becoming clear that the `cross talk' interactions between signalling systems are important features of dynamic cell regulation.
This volume is designed to summarize some aspects of the current work on various Second Messenger Systems and the integration of signals with respect to plasma membrane receptors. Second Messenger generation and degradation, protein kinase and phosphatase, cell cycle control, and cellular learning and memory.

• ATP
• Amino acid
• Calcium
• Glycogen
• Nucleotide
• Translation
• proteins

• Department of Biochemistry, University of West Indies, St. Augustine, Caribbean

  Junor A. Barnes, Haldane G. Coore

• Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden

  Abdul H. Mohammed

• Department of Pathology College of Medicine Saskatoon Cancer Center, University of Saskatoon, Saskatoon, Canada

  Rajendra K. Sharma

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