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Fetal Islet Transplantation

  • Book
  • © 1995

Overview

Editors:
  1. Charles M. Peterson

    1. Sansum Medical Research Foundation, Santa Barbara, USA

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  2. Lois Jovanovic-Peterson

    1. Sansum Medical Research Foundation, Santa Barbara, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Bent Formby

    1. Sansum Medical Research Foundation, Santa Barbara, USA

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. Protocols for Enhancing Function of Fetal Islets In Vitro and Following Transplantation

    • Alberto Hayek, Gillian M. Beattie
    Pages 1-13

  3. Expression of Two Non-Allelic Reg Genes in the Developing Human Pancreas: Effects in Vitro of Nicotinamide and Maternal Growth Factors

    • Bent Formby, Jean Falzone, Sheng Loh
    Pages 15-25

  4. Preparation of Fetal Islets for Transplantation: Importance of Growth Factors

    • Debra A. Hullett, Debra A. MacKenzie, Tausif Alam, Hans W. Sollinger
    Pages 27-36

  5. Studies of Fetal Porcine Islet-Like Cell Clusters—A Tissue Source for Xenotransplantation in Insulin-Dependent Diabetes Mellitus?

    • S. Sandler, L. Jansson, J.-O. Sandberg, N. Salari-Lak, A. Andersson, C. Hellerström
    Pages 37-50

  6. Basic Biology of Pig Fetal Pancreas and Its Use as an Allograft

    • Bernard E. Tuch, Ann M. Simpson, Murray S. R. Smith, Patrick Waugh, Anthony J. Weinhaus, Jian Tu et al.
    Pages 51-68

  7. Combined Transplantation of Adult and Fetal Islets for Improvement of Graft Function: Prospective Approach for Diabetes Treatment

    • Yoko Mullen
    Pages 69-75

  8. Studies on Pretreatment of Human Fetal Islet In Vitro and Clinical Islet Transplantation in China

    • Yuan-Feng Hu, Jing-Juan Xu, Wei-Ping Dong, Yu-Fei Wang, Hong-De Zhang, Sheng-Rong Zhong et al.
    Pages 77-86

  9. The Use of Human Fetal Islet Tissue for Adjunctive Treatment in Insulin-Dependent Diabetic Patients: The Case for “Partial Success”

    • Lois Jovanovic-Peterson, Bent Formby, Alison Okada Wollitzer, Charles M. Peterson
    Pages 87-97

  10. Long-Term Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary

    • Gyula Farkas
    Pages 99-111

  11. Fetal Islet Transplantation and Pregnancy

    • Charles M. Peterson, Lois Jovanovic-Peterson, Hui-Min Chen, Wendy Bevier, Richard B. Pearce, Liberty Walker et al.
    Pages 113-136

  12. Encapsulated Human Islet Transplant Trials in Type I Diabetic Patients

    • Patrick Soon-Shiong
    Pages 137-149

  13. Optimal Surveillance of Diabetic Eye Disease

    • Barbara E. K. Klein, Ronald Klein, Scot E. Moss
    Pages 151-160

  14. Detection of Pancreatic Islet Transplant Rejection

    • Barbara Brooks-Worrell, Jerry Palmer
    Pages 161-174

  15. Networking for the Collection of Fetal Islet Tissues

    • Leatrice Ducat, Jane S. Schultz
    Pages 175-179

  16. Consensus Session Summary: Second International Symposium on Fetal Islet Transplantation

    • Paul E. Lacy, Stellan Sandler, Alberto Hayek, Jerry Palmer, Charles M. Peterson
    Pages 181-183

  17. Back Matter

    Pages 185-191
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Keywords

About this book

Despite the advent of insulin for clinical use in 1922, our ability to control hypergly­ cemia and prevent the long term sequelae ofthe disease remains limited. Thus normalization of the milieu interieur with physiologic responses of insulin and metabolites remains an elusive but critically important goal. The developing endocrine pancreas provides a model system that speaks to many challenges of the transplantation biologist. Thus the attempt to of vascularization, growth and development, immunologic toler­ recapitulate the ontogeny ance, and glucose responsive insulin secretory capacity of fetal islet tissue provides a tantalizing possibility to replace insulin secreting tissue in persons with diabetes. Studies of this tissue are also important because of the implications such investigations have for genetic and molecular biological approaches to restoring insulin secretion as well as for providing clues to enhancing the growth and repair of islets that have been the target of autoimmune disease. Investigators in the area offetal islet transplantation comprise a small group scattered throughout the world scientific community. Therefore it seemed important to provide a forum where these scientists could gather, share ideas, and achieve consensus such that progress in this rapidly evolving area could be facilitated. The conference would have remained a dream if the support of the Okla Basil Meade, Jr. family had not made it manifest.

Editors and Affiliations

  • Sansum Medical Research Foundation, Santa Barbara, USA

    Charles M. Peterson, Lois Jovanovic-Peterson, Bent Formby

Bibliographic Information

  • Book Title: Fetal Islet Transplantation

  • Editors: Charles M. Peterson, Lois Jovanovic-Peterson, Bent Formby

  • DOI: https://doi.org/10.1007/978-1-4615-1981-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1995

  • Hardcover ISBN: 978-0-306-45066-2Published: 30 June 1995

  • Softcover ISBN: 978-1-4613-5816-9Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1981-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 191

  • Topics: Diabetes, Internal Medicine, Immunology, Pharmacology/Toxicology

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