Dendritic Cells in Fundamental and Clinical Immunology

1. Front Matter

   Pages i-xix

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2. Dendritic Cells: Origin and Differentiation

   1. Characterization of Human CD34+ Derived Dendritic/Langerhans Cells (D-Lc)

      • C. Caux, B. Vanbervliet, C. Massacrier, B. Dubois, C. Dezutter-Dambuyant, D. Schmitt et al.

      Pages 1-5

   2. Stem Cell Factor Enhances Dendritic Cell Development

      • Frances Santiago-Schwarz, Karen Laky, Steven E. Carsons

      Pages 7-11

   3. Synergistic Interaction between c-kit Ligand (SCF), GM-CSF and TNF Promotes Optimal Dendritic Langerhans Cell Proliferation from Primitive Progenitors in Human Bone Marrow

      • Khaled Saraya, Cecil D. L. Reid

      Pages 13-16

   4. Progenitor Recruitment and in Vitro Expansion of Immunostimulatory Dendritic Cells from Human CD34⁺ Bone Marrow Cells by c-kit-Ligand, GM-CSF, and TNFα

      • Paul Szabolcs, Erika D. Feller, Malcolm A. S. Moore, James W. Young

      Pages 17-20

   5. Thymic Dendritic Cells: Surface Phenotype, Developmental Origin and Function

      • Ken Shortman, Li Wu, Carlos Ardavin, David Vremec, Frank Sotzik, Ken Winkel et al.

      Pages 21-29

   6. Recombinant GM-CSF Induces Cytokine Production in Mouse Dendritic Cell Clones

      • F. Granucci, G. Girolomoni, M. B. Lutz, P. Ricciardi-Castagnoli

      Pages 31-34

   7. Review of the Characteristics of Six Cell Lines with Langerhans Cell Phenotype

      • Rafael Nunez

      Pages 35-37

   8. Immortalized Murine Dendritic Cells: Phenotypic and Functional Characterization

      • Geoffrey Rowden, Shirley Dean, Pat Colp

      Pages 39-41

   9. Production and Properties of Large Numbers of Dendritic Cells from Human Blood

      • Gerold Schuler, Daniela Brang, Nikolaus Romani

      Pages 43-52

   10. A Simplified Method for Growing Dendritic Cells from Rat Bone Marrow

       • Melissa Chen-Woan, Conor P. Delaney, Veronique Fournier, Yoshitaka Wakizaka, Noriko Murase, Angus W. Thomson et al.

       Pages 53-55

   11. Transition of T3-Induced Monocyte-Derived Veiled/Dendritic Cells into Macrophage-Like Cells by Lipopolysaccharide

       • Frans G. A. Delemarre, Petra Mooij, Meeny de Haan-Meulman, Peter J. Simons, Harm J. de Wit, Hemmo A. Drexhage

       Pages 57-59

   12. Immunophenotypical and Functional Characterization of Bone Marrow Derived Dendritic Cells

       • Hubertus Hochrein, Frank Jährling, H.-Georg Kreysch, Arne Sutter

       Pages 61-63

   13. Expression of B7 Costimulator Molecules on Mouse Dendritic Cells

       • Kayo Inaba, Muneo Inaba, Margit Witmer-Pack, Karen Hathcock, Richard Hodes, Ralph M. Steinman

       Pages 65-70

   14. Development of Rat DC by in Vitro Culture of Bone Marrow Cells

       • M. Mehlig, C. Scheicher, H.-P. Dienes, K. Reske

       Pages 71-73

   15. Dendritic Cells Differentiated from Human Monocytes through a Combination of IL-4, GM-CSF and IFN-γ Exhibit Phenotype and Function of Blood Dendritic Cells

       • Hui Xu, Manuela Kramer, Hans.-P. Spengler, J. Hinrich Peters

       Pages 75-78

3. Dendritic Cells: Phenotype

   1. Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts

      • J. Banchereau, B. Dubois, J. Fayette, N. Burdin, F. Brière, P. Miossec et al.

      Pages 79-83

   2. Characterization of Human Blood Dendritic Cells: Cytokine Profiles

      • C. T. Tiemessen, S. Shalekoff, L. Morris, Y. Becker, D. J. Martin

      Pages 85-87

   3. Purification of Human Lung Dendritic Cells by Three Color Flow Cytometry

      • Jean-Pierre Aubry, Christine Power, Paul Life, Magdalena Schrader, Jean-Yves Bonnefoy

      Pages 89-91

   4. Identification of a Novel Cell Surface Protein Expressed by Murine Epidermal Langerhans Cells and Some Lymphoid Dendritic Cells

      • Teresa A. Borkowski, Andrew G. Farr, Andrew J. Nelson, Mark C. Udey

      Pages 93-95

These Proceedings contain the contributions of the partIcIpants of the Third International Symposium on Dendritic Cells that was held in Annecy, France, from June 19 to June 24, 1994. This symposium represented a follow-up of the first and second international symposia that were held in Japan in 1990 and in the Netherlands in 1992. Dendritic cells are antigen-presenting cells, and are found in all tissues and organs of the body. They can be classified into: (1) interstitial dendritic cells of the heart, kidney, gut, and lung;(2) Langerhans cells in the skin and mucous membranes; (3) interdigitating dendritic cells in the thymic medulla and secondary lymphoid tissue; and (4) blood dendritic cells and lymph dendritic cells (veiled cells). Although dendritic cells in each of these compartments are all CD45+ leukocytes that arise from the bone marrow, they may exhibit differences that relate to maturation state and microenvironment. Dendritic cells are specialized antigen-presenting cells for T lymphocytes: they process and present antigens efficiently in situ, and stimulate responses from naive and memory T cells in the paracortical area of secondary lymphoid organs. Recent evidence also demonstrates their role in induction of tolerance. By contrast, the primary and secondary B-cell follicles contain follicular dendritic cells that trap and retain intact antigen as immune complexes for long periods of time. The origin of follicular dendritic cells is not clear, but most investigators believe that these cells are not leukocytes.

• Antigen
• blood
• bone marrow
• development
• lymphocytes
• migration
• phenotype
• tissue
• transplantation

• Laboratory for Immunological Research, Schering-Plough, Dardilly, France

  Jacques Banchereau

• INSERM U346, Hôpital Edouard Herriot, Lyon, France

  Daniel Schmitt

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