Molecular and Subcellular Cardiology

1. Front Matter

   Pages i-xviii

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2. Molecular Mechanisms of Membrane Excitability

   1. Front Matter

      Pages 1-1

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   2. Ion Channels and Pumps in Cardiac Function

      • Harry A. Fozzard, Gregory Lipkind

      Pages 3-10

   3. Molecular Mechanisms of K+ Channel Blockade: 4-Aminopyridine Interaction with a Cloned Cardiac Transient K+ (Kv1.4) Channel

      • Randall L. Rasmusson, Ying Zhang, Donald L. Campbell, Mary B. Comer, Robert C. Castellino, Shuguang Liu et al.

      Pages 11-22

   4. Na+, K+-ATPase and Heart Excitability

      • David Lichtstein

      Pages 23-30

   5. Excitation-Contraction Coupling in Ventricular Myocytes: Effects of Angiotensin II

      • William H. Barry, Hiroshi Matsui, John H. B. Bridge, Kenneth W. Spitzer

      Pages 31-39

   6. Prospects for Genetic Manipulation of Cardiac Excitability

      • John H. Lawrence, David C. Johns, Nipavan Chiamvimonvat, H. Bradley Nuss, Eduardo Marban

      Pages 41-48

   7. Integrative Models and Responses in Cardiac Ischemia

      • Simon Horner, Max J. Lab

      Pages 49-60

   8. Rich Dynamics in a Simplified Excitable System

      • Shimon Marom, Amir Toib, Erez Braun

      Pages 61-66

   9. Model Studies of Cellular Excitation

      • Yoram Rudy

      Pages 67-77

3. Intracellular Calcium and Muscle Function: SR and Filaments

   1. Front Matter

      Pages 79-79

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   2. Confocal Microscopy Reveals Local SR Calcium Release in Voltage-Clamped Cardiac Cells

      • Withrow Gil Wier

      Pages 81-88

   3. Signaling of Ca2+ Release and Contraction in Cardiac Myocytes

      • Martin Morad

      Pages 89-96

   4. A Model of Ca2+ Release from the Sarcoplasmic Reticulum

      • Arkady Glukhovsky, Giora Amitzur, Dan Adam, Samuel Sideman

      Pages 97-108

   5. Troponin C — Troponin I Interactions and Molecular Signalling in Cardiac Myofilaments

      • R. John Solaro

      Pages 109-115

   6. The GATA-4 Transcription Factor Transactivates the Cardiac-Specific Troponin C Promoter-Enhancer in Non-Muscle Cells

      • S. Ip, David B. Wilson, Markku Heikinheimo, Jeffrey M. Leiden, Michael S. Parmacek

      Pages 117-124

   7. Sarcomere Function and Crossbridge Cycling

      • Henk E. D. J. ter Keurs

      Pages 125-135

   8. Crossbridge Dynamics in Muscle Contraction

      • Amir Landesberg, Rafael Beyar, Samuel Sideman

      Pages 137-153

   9. Mechanisms of the Frank-Starling Phenomena Studied in Intact Hearts

      • Daniel Burkhoff, Richard A. Stennett, Kazuhide Ogino

      Pages 155-161

4. Molecular Manifestations of Cell Adaptation

   1. Front Matter

      Pages 163-163

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The Henry Goldberg Workshops were set up to address the following goals: (1) To foster interdisciplinary interaction between scientists and cardiologists, identify missing links, and catalyze new ideas. (2) To relate basic microscale phenomena to the global, clinically manifested cardiac function. (3) To relate conceptual modeling and quantitative analysis to experimental and clinical data. (4) To encourage international cooperation so as to disperse medical and technological knowhow and lead to better understanding of the cardiac system. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between cardiac mechanics, electrical activation, perfusion, and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University in 1986, highlighted the transformation of the microscale activation phenomena to macroscale activity and performance, relating electrophysiology, energy metabolism, and cardiac mechanics. The fourth Goldberg Workshop, in 1987, continued the effort to elucidate the interactions among the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop, held in Cambridge, UK, in 1988, dwelt on the effects of inhomogeneity of the cardiac muscle on its performance in health and disease. The sixth Workshop highlighted the role of new modem imaging techniques, that allow us to gain more insight into local and global cardiac performance in cardiac research and clinical practice.

• Activation
• cyclin
• endothelium
• genes
• imaging
• mechanics
• metabolism
• molecular mechanisms
• physiology
• regulation

• Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

  Samuel Sideman, Rafael Beyar

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