Ocular Toxicology

1. Front Matter

   Pages i-x

   PDF

2. Welcome and Opening of the Congress

   1. Welcome and Opening of the Congress

      • Ingo Weisse

      Pages 1-6

3. Ocular Electrophysiology

   1. The ERG, EOG, and VEP in Rats

      • Andrew M. Geller, Catherine M. Osborne, Robert L. Peiffer

      Pages 7-25

   2. Retinal Toxicology Study Using Electrophysiological Methods in Rabbits

      • Yutaka Shirao, Kazuo Kawasaki

      Pages 27-37

   3. ERG Measurements in the Dog, Cat and Monkey for Toxicology Specially Type of Electrode and Anesthesia for ERG Recordings

      • Bernard Clerc, Marie-José Sayn

      Pages 39-51

   4. Electroretinography in the Non-Human Primate as a Standardized Method in Toxicology

      • Walter H. Bee, Rainhart Korte, Friedhelm Vogel

      Pages 53-61

   5. Effects of Clindamycin on Neural Function in the Isolated Perfused Vertebrate Retina

      • Peter Walter, Christoph Lüke, Werner Sickel

      Pages 63-67

   6. Determination of the Effect of Ketamine, Thiopental and Halothane on the Ocular Electroretinographic Examination of the Beagle Dog to Define Protocols to be Used in Dogs, Monkeys and Micropigs

      • Olivier Loget, Gérard Saint-Macary

      Pages 69-77

   7. Experimental Study of the Retinal Toxicity of Iron after Vitreous Hemorrhage

      • Wei-Jia Nie, Xiao-Fang Zhang

      Pages 79-83

   8. Retinal Tolerance of Intravitreal Low-Molecular-Weight Heparin, Colchicine or Interferon ß Determined by Eye-Cup ERG in Albino Rabbits

      • Yohko Yamashita, Kiyofumi Mochizuki, Hiroyuki Sakai, Makoto Torisaki, Jhoji Tanabe

      Pages 85-91

   9. Normal ERG on Rhesus Monkeys (Macaca mulatta ): Preliminary Results of a Technic Using Subcutaneous Electrodes

      • Serge G. Rosolen, Hugues Malecki, Catherine Vandermercken

      Pages 93-97

   10. Effects of Quinine on the Electroretinogram of the Beagle Dog

       • Olivier Loget, Gérard Saint-Macary

       Pages 99-108

4. Ocular Pharmacokinetics

   1. Effect of Different Vehicles on Ocular Kinetics/Distribution

      • Marco Fabrizio Saettone

      Pages 109-120

   2. Drug Distribution Studies in Single Lens Layers Through the Application of A Sectioning Technique

      • Masami Kojima

      Pages 121-134

   3. Ocular Pharmacokinetics of Some Proteolytic Drugs in the Course of Topical Application: Long Term Observation

      • G. S. Polunin, M. N. Ivanov, A. A. Fedorov, A. N. Ovchinnikov

      Pages 135-144

   4. New Method of Reverse Intraaterial Drug Infusion into Final Periorbital Channels of Ophthalmic Artery in Urgent Treatment of Toxic Opticneuropathy

      • D. L. Bayandin, O. K. Vorobyeva, Y. G. Klimchenko

      Pages 145-152

   5. Evaluation of the Effect of the Vehicle on Ocular Distribution and Bioavailability of Betaxolol

      • Jeffrey Grove, Gilles Chastaing, Marie-Paule Quint, Annouk Rozier, Bernard Plazonnet

      Pages 153-159

   6. Continuous Flow Contact Lenses Delivery of Diclofenac to Rabbit Cornea and Aqueous Humor

      • V. Montoya, M. A. Company, M. Palmero, A. Orts

      Pages 161-165

   7. One-Year Ocular Toxicity Study of Ofloxacin Ophthalmic Solution in Beagle Dogs

      • Kenjiro Sawa, Mitsushi Hikida, Hiroyuki Mibu, Eiich Shirasawa, Kenji Takase, Hiroshi Suda

      Pages 167-179

   8. Topical Fluconazale: High Penetration without Corneal Toxicity

      • Kayo Uchiyama, Naoko Asano, Masafumi Ogata, Toshiro Tanahashi, Makoto Torisaki, Kiyofumi Mochizuki et al.

      Pages 181-190

On behalf of the editorial board and the organizing committee of the 4th congress of the International Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October 9 -13, 1994, we are pleased to present to the ocular toxicology community this indexed volume of our congress proceedings. The 4th congress was designed primarily to facilitate and update the knowledge in ocular electrophysiology and ocular pharmacokinetics, in both the clinical and preclinical aspects. The outcome of this 4th congress, established in this volume, is a useful contribution to the meth­ odology in both fields and will hopefully assist in the evaluation and interpretation of ocular findings recorded in animal studies on drugs and other chemicals, in order to protect human health. Undoubtedly, work on the mechanisms of ocular toxicology in the process of pharmaceutical development must continue and these proceedings, embodying the presented papers, will add to the data base. The editors, the congress organizing committee and the members of the International Society of Ocular Toxicology thank the speakers who gave their time, knowledge, and expertise to assist us in this project. The following manuscripts contain the main substance of each of the platform presentations and, in some cases, much more. Moreover, our thanks go to all the participants coming from a range of background- regulatory, academic and industrial -for their attention and excellent contributions during the discussion.

• development
• drug
• human health
• kinetics
• organophosphorus
• pharmacokinetics
• physiology
• research
• retina
• toxicity
• toxicology

• Boehringer Ingelheim KG, Ingelheim, Germany

  Ingo Weisse

• University of Bonn, Bonn, Germany

  Otto Hockwin

• Medical College of Georgia, Augusta, USA

  Keith Green

• South Carolina Eye Institute, Columbia, USA

  Ramesh C. Tripathi

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