Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

1. Front Matter

   Pages i-xii

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2. Cell Biology

   1. γδ T Lymphocytes in Mice and Man: A Review

      • Jannie Borst, Lex Bakker, Ferry Ossendorp

      Pages 1-16

   2. Ontogeny, Features and Functions of Epidermal T Lymphocytes

      • Georg Stingl, Elisabeth Payer, Adelheid Elbe

      Pages 17-27

   3. Activation of Reactive Versus Malignant T Cells in Cutaneous T Cell Lymphoma: Role of Abnormal Antigen Presenting Cells and T Cell Activating Molecules

      • Kevin D. Cooper, May-Sen Lee, Darius Mehregen, Erik Hansen, Ole Baadsgaard, Steen Lisby et al.

      Pages 29-38

   4. Factors Involved in the Localization and Activation of Murine γδ Positive Dendritic Epidermal T Cells

      • Robert E. Tigelaar, Julia M. Lewis

      Pages 39-55

   5. Morpho-Antigenic Features of Dendritic Cells as a Clue to the Interpretation of Skin Immune System-Related Disorders

      • Nicola Pimpinelli, Paolo Romagnoli, Marco Santucci, Benvenuto Giannotti

      Pages 57-76

   6. Cell Trafficking Networks in Cutaneous T Cell Lymphoma

      • David P. Fivenson, Brian J. Nickoloff

      Pages 77-93

3. Lymphocyte Homing

   1. Cytokine Neuropeptide Interactions in the Skin

      • T. A. Luger, A. Köck, E. Schauer, A. Schwarz, F. Trautinger, T. Schwarz

      Pages 95-102

   2. Effect of UV Light on Cytokine Production by Epidermal Cells

      • Thomas Schwarz, Agatha Urbanski, Franz Trautinger, Peter Neuner, Thomas A. Luger

      Pages 103-112

   3. Adhesion Molecules Involved in the Extravasation of Lymphocytes in Lymphoid Organs and Chronically Inflamed Tissues

      • A. C. H. M. van Dinther-Janssen, G. Kraal, R. J. Scheper, R. Willemze, C. J. L. M. Meijer

      Pages 113-140

   4. Adhesion Receptors in Normal Skin and Cutaneous Malignant Lymphomas: Pathophysiological and Clinical Correlations

      • Wolfram Sterry, Volker Mielke, Ulrich Konter, Imke Kellner, Wolf-Henning Boehncke

      Pages 141-155

   5. Integrins and Homing Receptors in Cutaneous Lymphomas

      • Emilio Berti, Paola Randi, Elena Roscetti, Domenico Delia

      Pages 157-175

4. Viruses

   1. A New Retrovirus from Cutaneous T-Cell Lymphoma

      • Vittorio Manzari, Loredana Albonici, Marco Ciotti, Maria Pia Lombardi, Ida Silvestri

      Pages 177-183

   2. Survey of Cutaneous T Cell Lymphomas for Human T-Lymphotropic Virus Infection

      • Michel D’Incan, Pierre Souteyrand, Yves-Jean Bignon, Claude Desgranges

      Pages 185-193

   3. HTLV-1 Proviral Sequences in Cutaneous CD30-Positive T Large Cell Lymphomas

      • Peter Kaudewitz, Iannis Anagnostopoulos, Michael Hummel, Harald Stein

      Pages 195-204

   4. Presence of Epstein-Barr Viral DNA and EBV Latent Gene Products in Hodgkin and Non-Hodgkin Lymphoma: High Expression of EBV-DNA Sequences in Non-Hodgkin Lymphoma with Variable Numbers Of CD30-Positive Cells

      • C. J. L. M. Meijer, P. Kanavaros, N. N. Jiwa, R. Willemze, P. C. de Bruin, J. M. M. Walboomers

      Pages 205-216

5. Histology

   1. Inflammatory Precursors of Mycosis Fungoides

      • W. Clark Lambert

      Pages 217-230

   2. The Histological Spectrum of Cutaneous T-Cell Lymphoma

      • Neil Smith

      Pages 231-242

   3. Cutaneous T-Cell Lymphoma: Clues to Diagnosis in Early Lesions

      • Marco Santucci

      Pages 243-254

   4. Morphologic and Prognostic Features of Advanced Mycosis Fungoides

      • Helmut Kerl, Lorenzo Cerroni, Stefan Hoedl

      Pages 255-263

This book is based upon a series of papers originally presented at a NATO Advanced Studies Workshop of the same title held at the study Center HI Cappuccini," a converted monastery in San Miniato, a small village located between Pisa and Florence, Italy, in October 1991. Authors were asked to submit their completed chapters by the following February; these were then scanned onto computer disks, edited and returned to the authors for final revision, and updating, with a final deadline of February 1993. The authors were encouraged to make whatever modifications they wanted, especially regarding updating their chapters, with an eye to making the final product both comprehensive and current. In this we succeeded beyond our expectations, with most chapters extensively altered and many completely re-written and significantly expanded. Thus, although the original meeting was held in 1991, the chapters in this volume may be regarded as current from at least February, 1993, with some of the final updated revisions received as late as July, 1993. This book, as agreed in our original contract, has been delivered to the publisher "camera-ready. " This means that all of the scanning, editing, proofing and typesetting were done here, by the office of the Department of Dermatology at the New Jersey Medical School. We essentially produced the book, which the publisher, for the most part, then photocopied. This has been an enormous burden, borne mainly by my colleague in this division, Robert A.

• biology
• cell
• cell biology
• dermatology
• genes
• histology
• infection
• lymphocytes
• lymphoma
• proliferation
• protein
• retroviruses
• skin
• tumor
• tumor progression

• UMD-New Jersey Medical School, Newark, USA

  W. Clark Lambert

• University of Florence, Florence, Italy

  Benvenuto Giannotti

• University Hospital, Utrecht, Utrecht, The Netherlands

  Willem A. Vloten

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