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Free Radicals in Diagnostic Medicine

A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy

  • Book
  • © 1994

Overview

Editors:
  1. Donald Armstrong

    1. State University of New York at Buffalo, Buffalo, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 366)

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Table of contents (50 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  3. Organ Specific Disorders

    1. Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids

      • Domenico E. Pellegrini-Giampietro
      Pages 59-71

    2. Free Radicals and Ocular Disease

      • Robert E. Anderson, Frank L. Kretzer, Laurence M. Rapp
      Pages 73-86

    3. Active Oxygen Mechanisms of UV Inflammation

      • Alice P. Pentland
      Pages 87-97

    4. Oxygen-Free Radicals at Myocardial Level: Effects of Ischaemia and Reperfusion

      • Roberto Ferrari
      Pages 99-111

    5. Mechanisms of Atherosclerosis: Role of LDL Oxidation

      • Peter D. Reaven
      Pages 113-128

    6. Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury

      • Edward J. Lesnefsky
      Pages 129-146

    7. Free Radicals in the Pathophysiology of Pulmonary Injury and Disease

      • Daniel J. Brackett, Paul B. McCay
      Pages 147-163

    8. Lipid Peroxides in Hepatic, Gastrointestinal, and Pancreatic Diseases

      • Kunio Yagi
      Pages 165-169

    9. Reactive Oxygen Molecules in the Kidney

      • Wayne R. Waz, Leonard G. Feld
      Pages 171-183

    10. Reactive Oxygen Species (ROS) and Reproduction

      • Eve de Lamirande, Claude Gagnon
      Pages 185-197

  4. Systemic Involvement

    1. Autoimmune and Inflammatory Diseases

      • Jonathan A. Leff
      Pages 199-213

    2. Antioxidants and Cancer: Molecular Mechanisms

      • Peter J. O’Brien
      Pages 215-239

    3. New Directions for Free Radical Cancer Research and Medical Applications

      • Stephen M. Hahn, C. Murali Krishna, James B. Mitchell
      Pages 241-251

    4. Shock and Multiple Organ Failure

      • Patricia A. Abello, Timothy G. Buchman, Gregory B. Bulkley
      Pages 253-268

    5. Role of Nutrients in the Cause and Prevention of Oxygen Radical Pathology

      • Harold H. Draper, William J. Bettger
      Pages 269-289
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Keywords

About this book

An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry. The theme was "A Systems Approach To Laboratory Technology, Clinical Correlations And Antioxidant Therapy." The symposium was held on October 7-8, 1993 at the Hyatt Hotel and on October 9 at Roswell Park Cancer Institute, Buffalo, New York. This proceedings volume contains chapters from platform presentations, poster sessions and from invited special lectures in the areas of basic science, clinical applications and efficacy of treatment. A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan. The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than 5.0 and a diabetic person with vascular complications often exceeds 7.5 nmol/ml. Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions relative to the amount of lipid peroxidation. The BASIC SCIENCES portion of the program examined: "Mechanisms of Action, Pathophysiology and Laboratory Tests" in six presentations.

Editors and Affiliations

  • State University of New York at Buffalo, Buffalo, USA

    Donald Armstrong

Bibliographic Information

  • Book Title: Free Radicals in Diagnostic Medicine

  • Book Subtitle: A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy

  • Editors: Donald Armstrong

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1833-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1994

  • Hardcover ISBN: 978-0-306-44981-9Published: 28 February 1995

  • Softcover ISBN: 978-1-4613-5742-1Published: 23 October 2012

  • eBook ISBN: 978-1-4615-1833-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 464

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Pharmacy

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