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Selenium

Its Molecular Biology and Role in Human Health

  • Book
  • © 2001

Overview

Editors:
  1. Dolph L. Hatfield

    1. National Cancer Institute, USA

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    1. Introduction

      • Dolph L. Hatfield
      Pages 1-4

  3. Biosynthesis of selenocysteine and its incorporation into protein

    1. Front Matter

      Pages 5-5
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    2. Selenium metabolism in bacteria

      • August Böck
      Pages 7-22

    3. Mammalian selenocysteine tRNA

      • Bradley A. Carlson, F. Javier Martin-Romero, Easwari Kumaraswamy, Mohamed E. Moustafa, Huijun Zhi, Dolph L. Hatfield et al.
      Pages 23-32

    4. Selenophosphate — selenium donor for protein and tRNA

      • Gerard M. Lacourciere
      Pages 33-43

    5. SECIS elements

      • Glover W. Martin III, Marla J. Berry
      Pages 45-53

    6. SECIS binding proteins

      • Paul R. Copeland, Donna M. Driscoll
      Pages 55-67

    7. Towards a mechanism for selenocysteine incorporation in eukaryotes

      • John B. Mansell, Marla J. Berry
      Pages 69-80

    8. Regulation of selenoprotein expression

      • Roger A. Sunde
      Pages 81-96

  4. Selenium-containing proteins

    1. Front Matter

      Pages 97-97
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    2. Identity, evolution and function of selenoproteins and selenoprotein genes

      • Vadim N. Gladyshev
      Pages 99-114

    3. Bacterial selenoenzymes and mechanisms of action

      • Thressa C. Stadtman
      Pages 115-122

    4. Selenoprotein P

      • Kristina E. Hill, Raymond F. Burk
      Pages 123-135

    5. Selenoprotein W: A muscle protein in search of a function

      • L. Walt Ream, William R. Vorachek, Philip D. Whanger
      Pages 137-146

    6. The 15 kDa selenoprotein (Sep15): functional studies and a role in cancer etiology

      • Vadim N. Gladyshev, Alan M. Diamond, Dolph L. Hatfield
      Pages 147-155

    7. Selenoproteins of the glutathione system

      • Leopold Flohé, Regina Brigelius-Flohé
      Pages 157-178

    8. Selenoproteins of the thioredoxin system

      • Arne Holmgren
      Pages 179-188

    9. Selenium, deiodinases and endocrine function

      • Donald L. St. Germain
      Pages 189-202

  5. Selenium and human health

    1. Front Matter

      Pages 203-203
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Keywords

About this book

As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.

Editors and Affiliations

  • National Cancer Institute, USA

    Dolph L. Hatfield

Bibliographic Information

  • Book Title: Selenium

  • Book Subtitle: Its Molecular Biology and Role in Human Health

  • Editors: Dolph L. Hatfield

  • DOI: https://doi.org/10.1007/978-1-4615-1609-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-7923-7335-3Published: 30 June 2001

  • Softcover ISBN: 978-1-4613-5639-4Published: 24 October 2012

  • eBook ISBN: 978-1-4615-1609-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIX, 326

  • Topics: Nutrition, Animal Anatomy / Morphology / Histology, Biochemistry, general, Cancer Research, Virology

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