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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

Insights for Drug Discovery

  • Book
  • © 2001

Overview

Editors:
  1. Tucker Collins

    1. Harvard Medical School, USA

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Selectins in Leukocyte Recruitment

    • Rodger P. McEver
    Pages 1-26

  3. Transcriptional Regulation of the E-Selectin Gene

    • Tucker Collins, Kelly-Ann Sheppard, Simos Simeonidis, David W. Rose
    Pages 27-53

  4. The Immunoglobulin Superfamily in Leukocyte Recruitment

    • Ulrich H. von Andrian
    Pages 55-107

  5. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression

    • Thomas P. Parks, Mary E. Gerritsen
    Pages 109-173

  6. Transcriptional Regulation of VCAM-1

    • Andrew Neish, Sarita Aggarwal, Tucker Collins
    Pages 175-201

  7. Activation of Nuclear Factor-κB

    • Frank S. Lee, Robert T. Peters, Zhijian J. Chen, Tom Maniatis
    Pages 203-227

  8. The Basal Transcription Apparatus

    • Jeffrey D. Parvin, Stephen F. Anderson
    Pages 229-261

  9. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression

    • Mary E. Gerritsen
    Pages 263-301

  10. The NF-κB System and Drug Discovery

    • Anthony M. Manning
    Pages 303-321

  11. Back Matter

    Pages 323-327
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Keywords

About this book

The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers.
This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment.
This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Editors and Affiliations

  • Harvard Medical School, USA

    Tucker Collins

Bibliographic Information

  • Book Title: Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

  • Book Subtitle: Insights for Drug Discovery

  • Editors: Tucker Collins

  • DOI: https://doi.org/10.1007/978-1-4615-1565-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-7923-7223-3Published: 30 November 2000

  • Softcover ISBN: 978-1-4613-5617-2Published: 05 November 2012

  • eBook ISBN: 978-1-4615-1565-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 327

  • Topics: Pathology, Microbiology, Veterinary Medicine/Veterinary Science, Biochemistry, general, Pneumology/Respiratory System

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