The Role of Inflammatory Mediators in the Failing Heart

1. Front Matter

   Pages i-vii

   PDF

2. The Role of Inflammatory Mediators in the Failing Heart

   • Douglas L. Mann

   Pages 1-1

3. Recent Insights into the Role of Tumor Necrosis Factor in the Failing Heart

   • Douglas L. Mann

   Pages 3-12

4. The Role of Interleukin-1 in the Failing Heart

   • Carlin S. Long

   Pages 13-25

5. The Role of Interleukin-6 in the Failing Heart

   • Kai C. Wollert, Helmut Drexler

   Pages 27-34

6. The Role of Nitric Oxide in the Failing Heart

   • Walter J. Paulus

   Pages 35-48

7. Interactions Between Cytokines and Neurohormonal Systems in the Failing Heart

   • Hong Kan, Mitchell S. Finkel

   Pages 49-57

8. Experimental Heart Failure Models of Cytokine Overexpression

   • Charles F. McTiernan, Toshi Kadokami, Yun You Li, Arthur M. Feldman

   Pages 59-68

9. Immunomodulation of Cytokines in Experimental Models of Heart Failure

   • Akira Matsumori, Shigetake Sasayama

   Pages 69-76

10. The Effect of Cytokines on Cardiac Allograft Function: Tumor Necrosis Factor-α: A Mediator of Chronic Injury

    • Alex Perez-Verdia, Sonny J. Stetson, Susan McRee, Wojciech Mazur, Michael M. Koerner, Guillermo Torre-Amione

    Pages 77-81

11. The Role of Anti-Cytokine Therapy in the Failing Heart

    • Anita Deswal, Arunima Misra, Biykem Bozkurt

    Pages 83-91

12. The Syndrome of Cardiac Cachexia

    • Stefan D. Anker, Rakesh Sharma

    Pages 93-103

13. Back Matter

    Pages 105-110

    PDF

Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states. Over the past decade there has been increasing interest in the potential role that inflammatory mediators, play in a variety of cardiac disease states, including chronic heart failure.
The Role of Inflammatory Mediators in the Failing Heart provides a state-of-the-art review on inflammatory mediators and the failing heart. This book will serve both as a useful introduction to the field, as well as an update for those interested in the role of inflammatory mediators and the failing heart.

• cytokine
• cytokines
• heart
• heart disease
• heart failure
• immunomodulation
• inflammation
• necrosis
• nitric oxide
• pathogenesis
• therapy
• tumor

• Baylor College of Medicine, Houston, USA

  Douglas L. Mann

Policies and ethics