Molecular Biology of Acute Lung Injury

1. Front Matter

   Pages i-xiii

   PDF

2. Signal Transduction Pathways in Acute Lung Injury: Nf-κB and Ap-1

   • Thomas P. Shanley, Hector R. Wong

   Pages 1-16

3. Innate Immune Mechanisms Triggering Lung Injury

   • Robert M. Strieter, John A. Belperio, David Kelley, Ammar Sakkour, Michael P. Keane

   Pages 17-33

4. The Role of Chemokines in the Recruitment of Leukocytes During Lung Inflammation

   • Robert M. Strieter, John A. Belperio, David Kelley, Ammar Sakkour, Michael P. Keane

   Pages 35-51

5. Regulation of Lung Immunity: Significance of the Cytokine Environment

   • Nicholas W. Lukacs, Theodore Standiford, Cory Hogaboam, Steven L. Kunkel

   Pages 53-69

6. Role of Complement in Acute Lung Injury

   • Markus S. Huber-Lang, Peter A. Ward

   Pages 71-81

7. Oxidant Stress in Acute Lung Injury

   • Jerry J. Zimmerman

   Pages 83-99

8. Endogenous Nitric Oxide in Acute Lung Injury

   • Neil W. Kooy

   Pages 101-117

9. Heme Oxygenase-1 in Acute Lung Injury

   • Jigme M. Sethi, Augustine M. K. Choi

   Pages 119-132

10. Pulmonary Endothelial Surface Redox Activity: Roles in Propagation of and Protection from Injury

    • Marilyn P. Merker, Robert D. Bongard, Christopher A. Dawson

    Pages 133-148

11. Mechanisms of Lung Epithelial Cell Injury by Pseudomonas Aeruginosa

    • Jeanine P. Wiener-Kronish, Dara Frank, Teiji Sawa

    Pages 149-161

12. Alveolar Epithelial Repair in Acute Lung Injury

    • Thomas K. Geiser, Michael A. Matthay

    Pages 163-176

13. Molecular Basis for Surfactant Function in ARDS

    • Liqian Zhang, Jeffrey A. Whitsett

    Pages 177-191

14. Pulmonary Collectins and Defensins

    • Ann Marie LeVine

    Pages 193-211

15. Lung Repair, Remodeling, and Fibrosis

    • Sujata Guharoy, Sem H. Phan

    Pages 213-227

16. Apoptosis in Acute Lung Injury

    • Karine Faure, Benoit Guery, Jean Francois Pittet

    Pages 229-244

17. Corticosteroid Treatment in Unresolving ARDS

    • G. Umberto Meduri

    Pages 245-256

18. Anti-Inflammatory Cytokines: Role in Regulation of Acute Lung Injury

    • Thomas P. Shanley

    Pages 257-273

19. The Heat Shock Response and Heat Shock Protein 70: Cytoprotection in Acute Lung Injury

    • Hector R. Wong

    Pages 275-288

20. Biotrauma: Signal Transduction and Gene Expression in the Lung

    • Claudia C. dos Santos, Mingyao Liu, Arthur S. Slutsky

    Pages 289-325

Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.

• Atmen
• Chemokine
• Trauma
• pathophysiology
• physiology

• Division of Critical Care Medicine, Children’s Hospital Medical Center and Children’s Hospital Research Foundation, Cincinnati, USA

  Hector R. Wong, Thomas P. Shanley

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