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Potassium Channels in Cardiovascular Biology

  • Book
  • © 2001

Overview

Editors:
  1. Stephen L. Archer

    1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Nancy J. Rusch

    1. Medical College of Wisconsin, Milwaukee, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xlv
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  2. Molecular Biology of Potassium Channels

    1. Front Matter

      Pages 1-1
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    2. Evolution of Potassium Channel Proteins

      • Warren J. Gallin, Andrew N. Spencer
      Pages 3-16

    3. Three-Dimensional Structure of the K+Channel Pore: Basis for Ion Selectivity and Permeability

      • Hee-Cheol Cho, Peter H. Backx
      Pages 17-34

    4. Molecular Biology of Voltage-Gated K+Channels

      • Olaf Pongs
      Pages 35-48

    5. Molecular Biology of High-Conductance, Ca2+-Activated Potassium Channels

      • Pratap Meera, Martin Wallner, Ligia Toro
      Pages 49-70

    6. Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels

      • S. L. Shyng, A. N. Lopatin, C. G. Nichols
      Pages 71-88

  3. Potassium Channel Expression and Function

    1. Front Matter

      Pages 89-89
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    2. Design and Use of Antibodies for Mapping K+Channel Expression in the Cardiovascular System

      • Robert O. Koch, Maria Trieb, Alexandra Koschak, Siegmund G. Wanner, Kathryn M. Gauthier, Nancy J. Rusch et al.
      Pages 91-102

    3. Molecular Methods for Evaluation of K+Channel Expression and Distribution in the Heart

      • Michael J. Morales, Mulugu V. Brahmajothi, Donald L. Campbell, Harold C. Strauss
      Pages 103-118

    4. Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K+Currents in Cardiac and Vascular Myocytes

      • Antonio Guia, Carmelle V. Remillard, Normand Leblanc
      Pages 119-142

    5. The Patch-Clamp Technique for Measurement of K+Channels in Xenopus Oocytes and Mammalian Expression Systems

      • Laura Conforti, Nicholas Sperelakis
      Pages 143-161

    6. Heteromultimer Formation in Native K+Channels

      • James S. Trimmer, Kenneth J. Rhodes
      Pages 163-175

    7. Use of Transgenic and Gene-Targeted Mice to Study K+Channel Function in the Cardiovascular System

      • Barry London
      Pages 177-191

  4. Pharmacology of Potassium Channels

    1. Front Matter

      Pages 193-193
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    2. Pharmacology of Voltage-Gated K+Channels

      • Brian Robertson
      Pages 195-217

    3. Pharmacology of High-Conductance, Ca2+-Activated Potassium Channels

      • Maria L. Garcia, Gregory J. Kaczorowski
      Pages 219-234

    4. Pharmacology of Small-Conductance, Calcium-Activated K+Channels

      • Eric Blanc, Hervé Darbon
      Pages 235-256

    5. Molecular Pharmacology of ATP-Sensitive K+Channels: How and Why?

      • Andre Terzic, Michel Vivaudou
      Pages 257-277

  5. Potassium Channels in the Heart

    1. Front Matter

      Pages 279-279
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Keywords

About this book

Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.

Editors and Affiliations

  • Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Canada

    Stephen L. Archer

  • Medical College of Wisconsin, Milwaukee, USA

    Nancy J. Rusch

Bibliographic Information

  • Book Title: Potassium Channels in Cardiovascular Biology

  • Editors: Stephen L. Archer, Nancy J. Rusch

  • DOI: https://doi.org/10.1007/978-1-4615-1303-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic / Plenum Publishers, New York 2001

  • Hardcover ISBN: 978-0-306-46402-7Published: 31 May 2001

  • Softcover ISBN: 978-1-4613-5487-1Published: 05 November 2012

  • eBook ISBN: 978-1-4615-1303-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XLVII, 899

  • Topics: Cardiology, Pharmacology/Toxicology, Human Physiology, Medical Biochemistry, Biochemistry, general

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