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Clinically Relevant Resistance in Cancer Chemotherapy

  • Book
  • © 2002

Overview

Editors:
  1. Borje Andersson

    1. MD Anderson Cancer Center, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. David Murray

    1. Cross Cancer Institute, Edmonton, Canada

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Treatment and Research (CTAR, volume 112)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XX
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  2. Tumor Physiology and Resistance to Chemotherapy: Repopulation and Drug Penetration

    • Alison J. Davis, Ian F. Tannock
    Pages 1-26

  3. The Role of Membrane Transporters in Cellular Resistance to Anticancer Nucleoside Drugs

    • Marilyn L. Clarke, John R. Mackey, Stephen A. Baldwin, James D. Young, Carol E. Cass
    Pages 27-47

  4. MDR and MRP Gene Families as Cellular Determinant Factors for Resistance to Clinical Anticancer Agents

    • Lei Deng, Shigaru Tatebe, Yen-Chiu Lin-Lee, Toshihisa Ishikawa, M. Tien Kuo
    Pages 49-66

  5. The Glutathione System in Alkylator Resistance

    • David Hamilton, Nasser Fotouhi-Ardakani, Gerald Batist
    Pages 67-87

  6. The Role of Signal Transduction Pathways in Drug and Radiation Resistance

    • Steven Grant, Paul B. Fisher, Paul Dent
    Pages 89-108

  7. Mechanisms of Repair of Interstrand Crosslinks in DNA

    • Randy J. Legerski, Christopher Richie
    Pages 109-128

  8. DNA Repair in Resistance to Bifunctional Alkylating and Platinating Agents

    • David Murray
    Pages 129-160

  9. Leukemic Cell Insensitivity to Cyclophosphamide and other Oxazaphosphorines Mediated by Aldehyde Dehydrogenase(s)

    • Norman E. Sládek
    Pages 161-175

  10. Mechanisms of Resistance against Cyclophosphamide and Ifosfamide: Can they be Overcome without Sacrificing Selectivity?

    • Susan M. Ludeman, Michael P. Gamcsik
    Pages 177-197

  11. Cellular Mechanisms of Cyclophosphamide Resistance: Model Studies in Human Medulloblastoma Cell Lines

    • Henry S. Friedman, Stewart P. Johnson, O. Michael Colvin
    Pages 199-209

  12. Model Studies of Cyclophosphamide Resistance in Human Myeloid Leukemia

    • Borje S. Andersson, David Murray
    Pages 211-235

  13. Mechanisms of Drug Resistance in AML

    • Michael Andreeff, Marina Konopleva
    Pages 237-262

  14. Biochemical and Molecular Mechanisms of Cisplatin Resistance

    • Zahid H. Siddik
    Pages 263-284

  15. Modification of Radiosensitivity Following Chemotherapy Exposure: Potential Implications for Combined-Modality Therapy

    • Richard A. Britten
    Pages 285-303

  16. Clinical Pharmacology of Melphalan and Its Implications for Clinical Resistance to Anticancer Agents

    • Roy B. Jones
    Pages 305-322

  17. Pharmacological Considerations of Primary Alkylators

    • Jeannine S. McCune, John T. Slattery
    Pages 323-345

  18. Genomic Approaches to Clinical Drug Resistance

    • Sambasivarao Damaraju, Michael Sawyer, Brent Zanke
    Pages 347-372

  19. Back Matter

    Pages 373-380
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Keywords

About this book

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

Editors and Affiliations

  • MD Anderson Cancer Center, Houston, USA

    Borje Andersson

  • Cross Cancer Institute, Edmonton, Canada

    David Murray

Bibliographic Information

  • Book Title: Clinically Relevant Resistance in Cancer Chemotherapy

  • Editors: Borje Andersson, David Murray

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4615-1173-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-1-4020-7200-0Published: 31 October 2002

  • Softcover ISBN: 978-1-4613-5428-4Published: 23 October 2012

  • eBook ISBN: 978-1-4615-1173-1Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XX, 380

  • Topics: Oncology, Cancer Research

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