Oxygen/Nitrogen Radicals: Cell Injury and Disease

1. Front Matter

   Pages i-1

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2. Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism

   • Earl R. Stadtman, Jackob Moskovitz, Barbara S. Berlett, Rodney L. Levine

   Pages 3-9

3. Signal transduction by nitric oxide in cellular stress responses

   • Bruce Demple

   Pages 11-18

4. Effects of antioxidants against atherosclerosis

   • Etsuo Niki, Noriko Noguchi

   Pages 19-25

5. Molecular pathology of dityrosine cross-links in proteins: Structural and functional analysis of four proteins

   • Dorairajan Balasubramanian, Ritu Kanwar

   Pages 27-38

6. The role of nitric oxide in lung innate immunity: Modulation by surfactant protein-A

   • Philip O’Reilly, Judy M. Hickman-Davis, Philip McArdle, K. Randall Young, Sadis Matalon

   Pages 39-48

7. Redox signaling

   • Henry Jay Forman, Martine Torres, Jon Fukuto

   Pages 49-62

8. Control of mitochondrial membrane potential and ROS formation by reversible phosphorylation of cytochrome c oxidase

   • Icksoo Lee, Elisabeth Bender, Bernhard Kadenbach

   Pages 63-70

9. Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

   • Rebecca L. Persinger, Matthew E. Poynter, Karina Ckless, Yvonne M. W. Janssen-Heininger

   Pages 71-80

10. Differential role of hydrogen peroxide in UV-induced signal transduction

    • Min Ding, Jingxia Li, Stephen S. Leonard, Xianglin Shi, Max Costa, Vincent Castranova et al.

    Pages 81-90

11. Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-кB and STAT-1 in ozone-induced nitric oxide production and toxicity

    • Debra L. Laskin, Ladan Fakhrzadeh, Diane E. Heck, Donald Gerecke, Jeffrey D. Laskin

    Pages 91-98

12. Phospholipase D/phosphatidic acid signal transduction: Role and physiological significance in lung

    • Rhett Cummings, Narasimham Parinandi, Lixin Wang, Peter Usatyuk, Viswanathan Natarajan

    Pages 99-109

13. Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates

    • Maria E. Ramos-Nino, Astrid Haegens, Arti Shukla, Brooke T. Mossman

    Pages 111-118

14. Doxorubicin-induced apoptosis: Implications in cardiotoxicity

    • B. Kalyanaraman, Joy Joseph, Shashi Kalivendi, Suwei Wang, Eugene Konorev, Srigiridhar Kotamraju

    Pages 119-124

15. Depletion of Bc1-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells

    • Patrick P. Koty, Yulia Y. Tyurina, Vladimir A. Tyurin, Shang-Xi Liu, Valerian E. Kagan

    Pages 125-133

16. Interactions of copper with glycated proteins:Possible involvement in the etiology of diabetic neuropathy

    • John W. Eaton, Mingwei Qian

    Pages 135-142

17. Mechanisms of neutrophil-induced DNA damage in respiratory tract epithelial cells

    • Ad. M. Knaapen, Roel P. F. Schins, Dünya Polat, Andrea Becker, Paul J. A. Borm

    Pages 143-151

18. Asbestos-induced alveolar epithelial cell apoptosis:Role of mitochondrial dysfunction caused by iron-derived free radicals

    • David W. Kamp, Vijayalakshmi Panduri, Sigmund A. Weitzman, Navdeep Chandel

    Pages 153-160

19. Involvement of hydrogen peroxide in asbestos-induced NFAT activation

    • Jingxia Li, Chuanshu Huang, Bihui Huang, Xianglin Shi, Vincent Castranova, Val Vallyathan

    Pages 161-168

20. NF-кB, a pivotal transcription factor in silica-induced diseases

    • Fei Chen, Xianglin Shi

    Pages 169-176

A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.

• Activation
• Alveolar macrophages
• DNA
• Drogen
• Immunity
• Macrophages
• Nucleotide
• Oxidation
• gene expression
• hydrogen peroxide
• molecular mechanisms
• proteins
• regulation
• transcription
• translation

• Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, USA

  Val Vallyathan, Xianglin Shi, Vince Castranova

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