Overview
- Editors:
-
-
Lucio G. Costa
-
Department of Environmental Health, University of Washington, Seattle, USA
Department of Pharmacology and Physiology, University of Roma “La Sapienza”, Roma, Italy
-
Clement E. Furlong
-
Departments of Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, USA
Access this book
Other ways to access
Table of contents (10 chapters)
-
Front Matter
Pages i-xvii
-
-
- Denis Josse, Patrick Masson, Cynthia Bartels, Oksana Lockridge
Pages 27-52
-
- Victoria H. Brophy, Gail P. Jarvik, Clement E. Furlong
Pages 53-77
-
- Michael I. Mackness, Paul N. Durrington, Bharti Mackness
Pages 79-92
-
- Diana M. Shih, Srinivasa Reddy, Aldons J. Lusis
Pages 93-123
-
- Mohamad Navab, Susan Y. Hama, Alan C. Wagner, Greg Hough, Andrew D. Watson, Srinivasa T. Reddy et al.
Pages 125-136
-
- Ronald Zech, Jörg M. Chemnitius
Pages 137-163
-
- Lucio G. Costa, Wan-Fen Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, Clement E. Furlong
Pages 165-183
-
- Bharti Mackness, Paul N. Durrington, Michael I. Mackness
Pages 185-195
-
- Lucio G. Costa, Clement E. Furlong
Pages 197-210
-
Back Matter
Pages 211-216
About this book
The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure.
Editors and Affiliations
-
Department of Environmental Health, University of Washington, Seattle, USA
Lucio G. Costa
-
Department of Pharmacology and Physiology, University of Roma “La Sapienza”, Roma, Italy
Lucio G. Costa
-
Departments of Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, USA
Clement E. Furlong
