Mechanisms and Consequences of Proton Transport

1. Front Matter

   Pages iii-xiii

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2. Structure and Function of H,K-ATPase — Molecular Basis for Drug Targets

   1. The Gastric H,K-ATPase

      • Olga Vagin, Keith Munson, Jai Moo Shin, Nils Lambrecht, Steve Karlish, George Sachs

      Pages 1-17

   2. Human Nongastric H,K-ATPase: Current View On Structure And Functional Properties

      • Gail Adams, Manoranjani Tillekeratne, Nikolay B. Pestov, Nikolai N. Modyanov

      Pages 19-31

   3. Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases

      • Gilles Crambert, Pascal Beguin, Udo Hasler, Kathi Geering

      Pages 33-41

   4. HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colon

      • Henry J. Binder

      Pages 43-52

   5. Molecular Diversity and Regulatory Heterogeneity of the H+,K+-ATPases in Kidney

      • Thomas D. Dubose Jr., Juan Codina, Jian Li

      Pages 53-58

   6. Mutational Analysis of Gastric Proton Pump, α- and β-Subunits

      • Shinji Asano, Tohru Kimura, Takeguchi Noriaki

      Pages 59-70

   7. Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase

      • Jan Joep H. H. M. de Pont, Jan B. Koenderink, Herman G. P. Swarts, Peter H. G. M. Willems

      Pages 71-82

   8. The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase

      • E. C. Rabon, S. J. Rulli, E. V. Skripnikov

      Pages 83-90

3. Helicobacter Pylori and Mucosal Protection

   1. Host-Specific H. pylori Inhibition of H,K-ATPase α Subunit Gene Expression

      • Adam Smolka, Gö õ z Monika

      Pages 91-99

   2. H⁺K⁺-ATPase, the Dominant Gastric Autoantigen in Helicobacter pylori Infection

      • B. J. Appelmelk, M. P. Bergman, A. V. D. Aar, W. Lakhai, M. M. D’Elios, A. Azzurri et al.

      Pages 101-106

   3. The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis

      • Ban-Hock Toh, Mark Biondo, Aiden Marshall, Deanne Greenwood, John Sentry, Frank Alderuccio

      Pages 107-114

   4. Duodenal Protection: Influence of Melatonin and other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling

      • Gunnar Flemström, Markus Sjöblom

      Pages 115-122

   5. Role of Cytokines in Helicobacter pylori-Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation

      • Monika Gööz, Maria Shaker, Pal Gööz, Adam J. Smolka

      Pages 123-126

   6. HCl Causes Less Intracellular Acidification In Surface Epithelial Cells Of Isolated Necturus Gastric Mucosa Than Other Inorganic Acids

      • T. Kiviluoto, O. Nylander-Koski, H. Mustonen, E. Kivilaakso

      Pages 127-130

   7. Ethanol Increases Intracellular Free Calcium, Closes Gap Junctions and Decreases Cell Volume in Primary Cultured Rabbit Gastric Epithelial Cell Monolayers

      • H. Mustonen, T. Kiviluoto, E. Kivilaakso

      Pages 131-134

   8. Induction of Small Intestinal Damage by Inhibition of Both NO Synthase and COX-2

      • Akiko Tanaka, Shoko Hase, Tohru Miyazawa, Kenji Kanatsu, Koji Takeuchi

      Pages 135-137

   9. Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats

      • Osamu Furukawa, Masahiko Hirokawa, Paul H. Guth, Eli Engel, Jonathan D. Kaunitz

      Pages 139-142

   10. Acid Induces Duodenal Epithelial Acidification and HC03 - Secretion via Activation of the Na+:HC03 - Cotransporter and CFTR in Mice

       • Masahiko Hirokawa, Osamu Furukawa, Paul H. Guth, Eli Engel, Shaoyou Chu, Marshall H. Montrose et al.

       Pages 143-145

4. Gene Targeting Mouse — Mechanisms of Acid Secretion and Cell Proliferation

   1. Insights Into the Cell Biology, Development and Pathology of the Gastric Mucosa Revealed in Gastric H/K ATPase and Gastrin-Deficient Mice

      • Ian R. Van Driel, Teo V. Franic, Louise M. Judd, Simon P. Barrett, Katrina L. Scarff, Linda C. Samuelson et al.

      Pages 147-157

This volume represents the proceedings of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Proton Transport" held in Leura, Australia, August 19 -21, 200 I. This conference has been held since 1971 every 3 to 4 years with few exceptions in association with the Congress of the International Union of Physiological Sciences. The first meeting was held in Frankfurt, Germany, at the Max-Planck'Institute. Countries hosting the conference have been Germany (twice), Sweden (twice), India, Canada, USA, Great Britain, and now Australia. Over the past 30 years participants at these Proton Transport Conferences have been principal contributors to the major discoveries in the physiology, biochemistry and pharmacology of gastric acid secretion. These include development of the H2-receptor blockers, defining the signaling pathways for the regulation of acid secretion, identifying the gastric proton pump, discovery and development of proton pump inhibitory drugs, and elucidating the physiology and biochemistry of Helicobacter pylori.

• ATP
• Activation
• Amino acid
• Calcium
• Colon
• gene expression
• influence
• proteins
• regulation

• Graduate School of Pharmaceutical Science, The University of Tokyo, Japan

  Tetsuro Urushidani

• Dept. of Molecular & Cell Biology, University of California at Berkeley, USA

  John G. Forte

• Center for Ulcer Research & Education, University of California, Los Angeles, USA

  George Sachs

Tetsuro Urushidani is an associate professor in the Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The University of Tokyo. John G. Forte is a professor in the Department of Molecular and Cell Biology, University of California at Berkeley. George Sachs is Director of the Membrane Biology Laboratory, University of California, Los Angeles, Professor of Physiology and Medicine, UCLA, Wilshire Chair in Medicine, UCLA, and Co-Director of the Center for Ulcer Research and Education, UCLA.

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