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  • Book
  • © 2002

Heme Oxygenase in Biology and Medicine

Editors:

  1. Nader G. Abraham

    1. New York Medical College, Valhalla, USA

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xix
    PDF

  2. Physiology/Pathology of Heme Oxygenase and its Products, Carbon Monoxide and Bilirubin

    1. Front Matter

      Pages 1-1
      PDF

    3. Carbon Monoxide

      • Stefan W. Ryter, Leo E. Otterbein, Danielle Morse, Augustine M. K. Choi
      Pages 19-29

    4. Correlation of the Altered Vascular Effects of Carbon Monoxide and the Cardiovascular Complications of Diabetes

      • Rui Wang, Xianfeng Sun, Lingyun Wu, Zunzhe Wang, Salma Toma Hanna, Robert Peterson-Wakeman
      Pages 31-41

    5. Endogenous Carbon Monoxide has Protective Roles in Neointimal Development Elicited by Arterial Injury

      • Toshisuke Morita, Yuko Togane, Makoto Suematsu, Jun-ichi Yamazaki, Shigehiro Katayama
      Pages 43-54

    6. End Tidal Breath Carbon Monoxide (ETCO) Levels in Pregnant Women

      • Daniel S. Seidman, Micha Baum, Doron Kreiser, Israel Hendler, Eyal Schiff, Maurice Druzin et al.
      Pages 55-65

    7. The Role of Heme Oxygenase in Pregnancy

      • Peter Hewett, Asif Ahmed
      Pages 67-82

    8. Increased Carbon Monoxide in Exhaled Air in Patients with Inflammatory Respiratory Diseases

      • Mutsuo Yamaya, Shoji Okinaga, Kiyohisa Sekizawa, Mizue Monma, Hidetada Sasaki
      Pages 83-95

    9. Carbon Monoxide and Iron, by-Products of Heme Oxygenase, Modulate Vascular Endothelial Growth Factor Synthesis in Vascular Smooth Muscle Cells

      • Józef Dulak, Roberto Motterlini, Ihor Huk, Otmar Pachinger, Franz Weidinger, Alicja Józkowicz
      Pages 97-107

  3. Physiological Function of Heme Oxygenase and the Central Nervous System

    1. Front Matter

      Pages 109-109
      PDF

    2. Co and Neonatal Cerebral Circulation

      • Charles W. Leffler, Jonathan H. Jaggar, Zheng Fan
      Pages 111-119

    3. Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS)

      • G. Scapagnini, A. M. Giuffrida Stella, N. G. Abraham, D. Alkon, V. Calabrese
      Pages 121-134

    4. Role of Heme Catabolism in Neurodegenerative Diseases

      • Atsushi Takeda, Yasuto Itoyama, Teiko Kimpara, R. Krishnan Kutty, Nader G. Abraham, Barney E. Dwyer et al.
      Pages 135-143

    5. Heme Oxygenase-1 and Alzheimer Disease

      • Yogesh Mawal, Daniel Berlin, Steven Kravitz, Hyman M. Schipper
      Pages 145-155

    7. Heme Oxygenase (HO)-1 Expressing Macrophages/Microglial Cells Accumulate During Oligodendroglioma Progression

      • Martin H. Deininger, Richard Meyermann, Hermann J. Schluesener
      Pages 169-180

  4. Clinical Implications of Heme Oxygenase System in Inflammation

    1. Front Matter

      Pages 181-181
      PDF

    2. Heme Oxygenase and Ocular Surface Inflammation

      • Michael W. Dunn, Michal Laniado-Schwartzman
      Pages 183-192

    3. Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia

      • Stella Kourembanas, Tohru Minamino, Helen Christou, Chung-Ming Hsieh, Yuxiang Liu, Vijender Dhawan et al.
      Pages 193-204
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About this book

Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter­ acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod­ ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis­ ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
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Keywords

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Editors and Affiliations

  • New York Medical College, Valhalla, USA

    Nader G. Abraham

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Bibliographic Information

  • Book Title: Heme Oxygenase in Biology and Medicine

  • Editors: Nader G. Abraham

  • DOI: https://doi.org/10.1007/978-1-4615-0741-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-306-47264-0Published: 31 August 2002

  • Softcover ISBN: 978-1-4613-5219-8Published: 13 October 2012

  • eBook ISBN: 978-1-4615-0741-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIX, 515

  • Topics: Oncology, Cancer Research, Human Genetics, Anatomy

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Buy it now

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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