Pediatric Gender Assignment

1. Front Matter

   Pages i-xiv

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2. SRY and the Genetics of Sex Determination

   • Brian K. Jordan, Eric Vilain

   Pages 1-14

3. Gonadal Differentiation — Normal and Abnormal Testicular Development

   • Faruk Hadziselimovic, Dale Huff

   Pages 15-23

4. Mullerian Inhibiting Substance: An Update

   • David T. MacLaughlin, Patricia K. Donahoe

   Pages 25-40

5. Micropenis: An Animal Model and its Human Correlates

   • Douglas A. Husmann

   Pages 41-56

6. Hypothalamic Imprinting by Gonadal Steroid Hormones

   • Roger A. Gorski

   Pages 57-73

7. Sexual Differentiation of the Human Hypothalamus

   • Dick F. Swaab, Wilson C. J. Chung, Frank P. M. Kruijver, Michael A. Hofman, Tatjana A. Ishunina

   Pages 75-105

8. The Endocrinologist’s Approach to the Intersex Patient

   • Perrin C. White

   Pages 107-120

9. 5α-Reductase-2 Deficiency and Complete Androgen Insensitivity: Lessons from Nature

   • J. Imperato-McGinley

   Pages 121-134

10. The Chop Experience with Cloacal Exstrophy and Gender Reassignment

    • Stephen A. Zderic, Douglas A. Canning, Michael C. Carr, Christine Kodman-Jones, Howard-McC. Snyder

    Pages 135-147

11. A Framework for the Ethically Justified Clinical Management of Intersex Conditions

    • Laurence B. McCullough

    Pages 149-173

12. Gender Identity and Sex Assignment: A Reappraisal for the 21st Century

    • William G. Reiner

    Pages 175-197

13. Gender Assignment and Reassignment in Intersexuality: Controversies, Data, and Guidelines for Research

    • Heino F. L. Meyer-Bahlburg

    Pages 199-223

14. Prenatal Diagnosis and Treatment of Intersex States

    • Natalie E. Rintoul, Timothy M. Crombleholme

    Pages 225-238

15. Anatomical Studies of the Fetal Genitalia: Surgical Reconstructive Implications

    • Laurence S. Baskin

    Pages 239-249

16. Feminizing Genitoplasty

    • Terry W. Hensle, Jonathon Bingham

    Pages 251-266

17. Management of Cloacal Exstrophy

    • Michael E. Mitchell, Chadwick Plaire

    Pages 267-273

18. Total Phallic Construction, Option to Gender Reassignment

    • Gerald H. Jordan

    Pages 275-282

19. Penile Reconstruction with a Free Sensate Osteocutaneous Fibula Flap in the Surgical Management of the Intersex Patient

    • J. William McRoberts, Richard C. Sadove

    Pages 283-288

20. Tissue Engineering Approaches for Genital Reconstruction

    • Anthony Atala

    Pages 289-303

This book represents the proceedings from a conference that took place in Dallas in the spring of 1999 which was entitled "Pediatric Gender Assignment - A Critical Reappraisal". Some participants rightfully argued that the conference really focused on the issue of pediatric gender assignment, and that reassignment was not applied in most cases. Their comments were reflected in the title of this monograph. This multidisciplinary meeting was sponsored by a conference grant from the National Institutes of Health, and a broad inquiry into this complex topic took place from many points of view. Basic scientists offered insight into mechanisms of sexual differentiation of the gonads, physical phenotype and imprinting of the central nervous system. Endocrinologists reviewed their experience in diagnosis and management, surgeons described traditional as well as innovative approaches, and there was strong representation from the ethical and behavioral sciences. In putting together such a panel, it was essential that we identify a cast of speakers who could address their viewpoints with strong convictions, and yet not let their passions render the meeting counter productive. We were not disappointed. While many differing points of view were firmly expressed by the panelists and audience, all viewpoints were accorded the respect they deserved. The concept behind the meeting and this book really originated in 1997 shortly after Diamond and Sigmundson published their long term follow up study of the John/Joan case.

• endocrinology
• ethics
• pediatric surgery
• pediatrics
• surgery
• urology
• diabetes

• Children’s Hospital of Philadelphia, Philadelphia, USA

  Stephen A. Zderic, Douglas A. Canning, Michael C. Carr, Howard McC. Snyder

Policies and ethics