The Physiological Genomics of the Critically Ill Mouse

1. Front Matter

   Pages i-xviii

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2. Physiological Monitoring of the Mouse

   1. Front Matter

      Pages 1-1

      PDF

   2. Assessment of Quality in Commercially Supplied Genetically Modified Animals

      • Adrian A. Deeny

      Pages 3-9

   3. Cannulation Techniques for Multiple Blood Withdrawal in Mice

      • Edwin Spoelstra, René Remie

      Pages 11-21

   4. Mouse Anesthesia in Relation to Optimal Hemodynamics

      • Coert J. Zuurbier, Vanessa M. Emons, Anneke Koeman, Can Ince

      Pages 23-34

   5. Mechanical Ventilation of Mice

      • Lothar A. Schwarte, Can Ince

      Pages 35-51

   6. Mouse Echocardiography

      • Attila Kovacs, Michael Courtois

      Pages 53-71

   7. Optical Spectroscopy in Mice

      • Egbert G. Mik, Can Ince

      Pages 73-88

   8. ECG Monitoring and Analyses in Mice

      • Ivo Amende, J. Matthew Dubach, Katrina Piskorski, James P. Morgan, Thomas G. Hampton

      Pages 89-100

   9. High-Definition Magnetic Resonance of Genetically Modified Mice

      • Klaas Nicolay, Gustav J. Strijkers, Jeanine J. Prompers, Maarten R. Drost

      Pages 101-117

   10. Pet Studies in the Mouse

       • Adriaan A. Lammertsma

       Pages 119-126

   11. Mouse Telemetry for Long-Term Monitoring

       • Klaas Kramer, Steve Hachtman

       Pages 127-141

3. Cardiovascular Pathophysiology of the Mouse

   1. Front Matter

      Pages 143-143

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   2. Physiological Genomics Of Reperfusion Injury

      • Thorsten Vowinkel, D. Neil Granger

      Pages 145-158

   3. Inos-Deficient Mice in the Study of Resuscitated Sepsis

      • Steven M. Hollenberg

      Pages 159-177

   4. The Microcirulation in Hypercholesterolemic Mice

      • Alina Constantinescu, Hans Vink

      Pages 179-186

   5. The Mouse in Shock

      • Martin G. Schwacha, Irshad H. Chaudry

      Pages 187-200

   6. Expression Systems to Analyze Transgenes in the Heart

      • Petra E. M. H. Habets, Antoon F. M. Moorman, Vincent M. Christoffels

      Pages 201-210

   7. Structural and Functional Adaptations of the Heart After Coronary Artery Ligation in the Mouse

      • Ben Janssen, Tijl De Celle, Jos Paquay, Jos Smits, Matthijs Blankesteijn

      Pages 211-224

   8. Mouse Models of Sepsis

      • Gerd Albuszies

      Pages 225-238

The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. It is a rapidly developing area of research and distinguishes itself from other areas of molecular medicine by its highly integrative nature. In this multi­ disciplinarian area of the physiological sciences, there is interaction between gene structure and physiological cardiovascular function as well as interactions between the different organs and their physiological compartments. The mouse has played a central role in the study of genomics due to the detailed knowledge of the mouse genome and the wide availability of genetically modified mice. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce. As more insight has come into the structural genomics of the mouse, however, it has become increasingly important to understand the relation between gene and physiological function. With this in mind we have been organizing the Amsterdam Mouse Symposia to bring together different disciplines interested in the molecular basis of cardiovascular function (see J. of Clinical and Exp. Pharmacology and rd Physiology (2002) 29:A69-AI02 for the proceedings of the 3 Amsterdam Mouse Symposium and Basic Research in Cardiology (2000) 95:492-535 for nd the proceedings of the 2 symposium).

• anesthesia
• animals
• cardiovascular
• cardiovascular system
• cell
• echocardiography
• electrocardiogram (ECG)
• gene therapy
• genes
• genomics
• heart
• hemodynamics
• physiology
• vascular disease

• Department of Physiology Academic Medical Center, University of Amsterdam, The Netherlands

  Can Ince

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