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The Sodium-Hydrogen Exchanger

From Molecule to its Role in Disease

  • Book
  • © 2003

Overview

Editors:
  1. Morris Karmazyn

    1. University of Western Ontario, London, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Metin Avkiran

    1. King’s College London, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Larry Fliegel

    1. University of Alberta, Edmonton, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical

  • Covers established and emerging concepts related to sodium hydrogen exchange including newly identified novel isoforms

  • Updates on completed and continuing clinical trials with sodium-hydrogen exchange inhibitors

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxxii
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  2. Regulation of Intracellular pH in Mammalian Cells

    • Kenneth W. Spitzer, Richard D. Vaughan-Jones
    Pages 1-15

  3. Molecular and Functional Diversity of Mammalian Na+/H+ Exchangers

    • John Orlowski, Sergio Grinstein
    Pages 17-34

  4. Two Fundamental Regulatory Factors of the Na+/H+ Exchangers

    • Shigeo Wakabayashi, Tianxiang Pang, Takashi Hisamitsu, Munekazu Shigekawa
    Pages 35-49

  5. Regulation of Expression of the Na+/H+ Exchanger in the Myocardium and Other Tissues

    • Larry Fliegel
    Pages 51-69

  6. Na-H Exchange Function in Colonic Epithelial Cells

    • Henry J. Binder, Vazhaikkurichi M. Rajendran, John Geibel
    Pages 71-90

  7. NhaA Na+/H+ Antiporter. Structure, Mechanism and Function in Homeostasis of Na+ and pH

    • Etana Padan, Abraham Rimon, Tzvi Tzubery, Marcus Müller, Katia Herz, Livnat Galili
    Pages 91-108

  8. The Use of Transgenic Animal Models to Study Na+/H+ Exchange

    • Larry Fliegel, Morris Karmazyn
    Pages 109-122

  9. pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo

    • Jay M. Baltz
    Pages 123-136

  10. Na+/H+ Exchanger Activation by Myocardial Stretch

    • Horacio E. Cingolani, Néstor G. Pérez, Irene L. Ennis, María C. Camilión de Hurtado
    Pages 137-148

  11. The Paradoxical Role of Na+/H+ Exchanger in the Diabetic Heart

    • Danielle Feuvray
    Pages 149-158

  12. Role of Na-H Exchanger in Vascular Remodelling in Diabetes

    • Peter J. Little, Rodney J. Dilley
    Pages 159-175

  13. The Potential Role of the Na+/H+ Exchanger in Ischemia/Reperfusion Injury of the Central Nervous System

    • John W. Phillis, Julie G. Pilitsis, Michael H. O’Regan
    Pages 177-189

  14. Receptor-Mediated Regulation of the Cardiac Sarcolemmal Na+/H+ Exchanger

    • Robert S. Haworth, Metin Avkiran
    Pages 191-209

  15. Role of NHE-1 in Cardiac Hypertrophy and Heart Failure

    • Morris Karmazyn
    Pages 211-219

  16. Mechanisms Underlying NHE-1 Involvement in Myocardial Ischemic and Reperfusion Injury

    • Morris Karmazyn
    Pages 221-237

  17. Chemistry of NHE Inhibitors

    • Hans Jochen Lang
    Pages 239-253

  18. Development of NHE Inhibitors for Cardiovascular Therapeutics

    • Wolfgang Scholz, Norbert Beier
    Pages 255-264

  19. Cardiac Protection by NHE Inhibitors

    • Garrett J. Gross
    Pages 265-278

  20. NHE-1 Inhibitors: Potential Application in Cardiac Surgery

    • M. Lee Myers
    Pages 279-290
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Keywords

About this book

I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.

Editors and Affiliations

  • University of Western Ontario, London, Canada

    Morris Karmazyn

  • King’s College London, UK

    Metin Avkiran

  • University of Alberta, Edmonton, Canada

    Larry Fliegel

Bibliographic Information

  • Book Title: The Sodium-Hydrogen Exchanger

  • Book Subtitle: From Molecule to its Role in Disease

  • Editors: Morris Karmazyn, Metin Avkiran, Larry Fliegel

  • DOI: https://doi.org/10.1007/978-1-4615-0427-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-4020-7474-5Published: 30 June 2003

  • Softcover ISBN: 978-1-4613-5071-2Published: 30 October 2012

  • eBook ISBN: 978-1-4615-0427-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXXII, 317

  • Topics: Cell Biology, Biochemistry, general, Pharmacology/Toxicology, Organic Chemistry, Cardiac Surgery

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