Neuronal and Vascular Plasticity

1. Front Matter

   Pages i-xiv

   PDF

2. Transformation into Treatment: Novel Therapeutics that Begin within the Cell

   • Kenneth Maiese, Zhao Zhong Chong, Jing-Qiong Kang

   Pages 1-26

3. Cholinergic Plasticity and the Meaning of Death

   • Michael McKinney, Karen Baskerville, David Personett, Katrina Williams, John Gonzales

   Pages 27-74

4. Restorative Potential of Angiogenesis after Ischemic Stroke

   • Ling Wei, Kejie Yin, Jin-Moo Lee, James Y. Chao, Shan Ping Yu, Teng-Nan Lin et al.

   Pages 75-94

5. Vascular Endothelial Function: Role of Gonadal Steroids

   • Sue Piper Duckles, Diana N. Krause

   Pages 95-115

6. Alterations of Synaptic Transmission Following Transient Cerebral Ischemia

   • Zao C. Xu

   Pages 117-134

7. The Future of Brain Protection: Natural Alternatives

   • Kenneth I. Maynard

   Pages 135-163

8. Iron S Involvement in the Molecular Mechanisms and Pathogenesis of Alzheimers Disease

   • Rebecca J. Henderson, James R. Connor

   Pages 165-188

9. Ethanol-Induced Neurodegeneration: Basic Mechanisms and Therapeutic Approaches

   • Paula L. Hoffman

   Pages 189-218

10. Regulation of Neural Stem Cells in the Adult Mammalian Brain

    • Feng C. Zhou, Rabindra P. Singh

    Pages 219-256

11. G-Protein Mediated Metabotropic Receptors Offer Novel Avenues in Neuronal and Vascular Cells for Cytoprotective Strategies

    • Zhao Zhong Chong, Jing-Qiong Kang, Kenneth Maiese

    Pages 257-298

12. Back Matter

    Pages 299-305

    PDF

Galen in the 2nd century AD could be considered one of the earliest researchers who attempted to bridge the gap between basic science and clinical medicine. Galen is given initial credit for the recognition that vital organs of the body are exquisitely dependent upon the intact function of the circulatory system. The doctrines of Galenic physiology stated that blood was produced in the liver, flowed to the heart to obtain "vital spirits", and subsequently bathed the brain to gain "animal spirits". The "vital spirits" described by Galen were later disclosed to consist of oxygen. Oxygen was discovered independently by Schiele in Sweden and by Priestly in England. It was named oxygen (acid-former) by Antoine Lavoisier (1743-1794) of France. Lavoisier made significant medical discoveries concerning oxygen's role in respiration. In animal experiments, Lavoisier and others discovered that anoxia could rapidly lead to death. The initial work by these investigators helped provide direction for modern clinical science and the treatment of disease, especially concerning disorders of the nervous system. Remarkably, our understanding of human disease continues to grow at an exponential rate. At times, the accumulation of knowledge of the cellular components of clinical disease exceeds all prior expectations held just a few years ago, such as evidenced by the recent cloning of the human and mouse genomes. Despite theses advances, both biomedical scientists and clinicians sometimes are at a loss to recognize the crucial link between basic science discovery and the development of therapeutic regiments for clinical disease.

• Alzheimer
• Nervous System
• alzheimer's disease
• brain
• central nervous system
• cerebral ischemia
• death
• neuroscience
• receptor
• stroke

• Division of Cellular and Molecular Cerebral Ischemia Center for Molecular Medicine Institute for Environmental Health Sciences, Wayne State University School of Medicine, Detroit, USA

  Kenneth Maiese

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