Cyclic ADP-Ribose and NAADP

1. Front Matter

   Pages I-XVIII

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2. Cyclic ADP-Ribose and NAADP

   • Hon Cheung Lee

   Pages 1-21

3. ADP-Ribosyl Cyclases - A Family of cADPR and NAADP Metabolizing Enzymes

   • Hon Cheung Lee, Cyrus B. Munshi, Richard Graeff

   Pages 23-43

4. Regulation of Synthesis of cADPR and NAADP

   • Antony Galione

   Pages 45-64

5. A Natural History of the Human CD38 Gene

   • Enza Ferrero, Fabio Malavasi

   Pages 65-79

6. A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes

   • Cyrus B. Munshi, Hon Cheung Lee

   Pages 81-99

7. Novel Cycling Assays for cADPR and NAADP

   • Richard Graeff, Hon Cheung Lee

   Pages 101-120

8. Pharmacology of Cyclic ADP-Ribose and NAADP

   • Timothy F. Walseth, Hon Cheung Lee

   Pages 121-142

9. Separate but Interacting Calcium Stores

   • Hon Cheung Lee

   Pages 143-166

10. Sensitizing Calcium-Induced Calcium Release

    • Anthony J. Morgan, Antony Galione

    Pages 167-197

11. Spatial and Temporal Control of Calcium Signaling by NAADP

    • Grant C. Churchill, Sandip Patel, Justyn M. Thomas, Antony Galione

    Pages 199-215

12. Regulation of Immune Responses by CD38 and cADPR

    • Frances E. Lund, Troy D. Randall, Santiago Partida-Sánchez

    Pages 217-240

13. Subcellular and Extracellular Trafficking of NAD+ and Cyclic ADP-Ribose: A New Way for Regulating Intracellular Calcium Homeostasis

    • Antonio De Flora, Lucrezia Guida, Luisa Franco, Santina Bruzzone, Elena Zocchi

    Pages 241-267

14. The CD38-Cyclic ADP-Ribose Signal System in Pancreatic ß-Cells

    • Shin Takasawa, Hiroshi Okamoto

    Pages 269-299

15. The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation

    • Andreas H. Guse

    Pages 301-318

16. Calcium Signaling by cADPR in Cardiac Myocytes

    • Stevan Rakovic, Derek A Terrar

    Pages 319-341

17. Cyclic ADP-Ribose and Vasomotor Response

    • Pin-Lan Li, Ai-Ping Zou, William B. Campbell

    Pages 343-363

18. Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic Acinar Cells

    • Jose Manuel Cancela

    Pages 365-379

19. Calcium and Calcium-Linked Second Messengers are Main Actors in the Maturation and Fertilization of Starfish Oocytes

    • Luigia Santella, Gilda A. Nusco, Dmitri Lim

    Pages 381-396

20. ADP-Ribosylation and CD38 Signaling

    • Uh-Hyun Kim, Myung-Kwan Han, Chang-Yeol Yim

    Pages 397-407

In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.

• Calcium
• Nucleotide
• metabolism
• pharmacology
• research
• synthesis

• Minneapolis, USA

  Hon Cheung Lee

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