Novel Angiogenic Mechanisms

1. Front Matter

   Pages i-ix

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2. Current Priorities in the Research of Circulating Pre-Endothelial Cells

   • Nicanor I. Moldovan

   Pages 1-8

3. In Vivo and in Vitro Properties of CD34+ and CD14+ Endothelial Cell Precursors

   • Gina C. Schatteman, Ola Awad

   Pages 9-16

4. Evidence from a Leukemia Model for Maintenance of Vascular Endothelium by Bone-Marrow-Derived Endothelial Cells

   • Eberhard Gunsilius

   Pages 17-24

5. Cross Talk between Haematopoiesis and Angiogenesis

   • Domenico Ribatti, Angelo Vacca, Beatrice Nico, Enrico Crivellato, Giuseppe De Falco, Marco Presta

   Pages 25-36

6. The Contribution of Adult Hematopoietic Stem Cells to Retinal Neovascularization

   • Maria B. Grant, Sergio Caballero, Gary A. J. Brown, Steven M. Guthrie, Robert N. Mames, Timothy Vaught et al.

   Pages 37-45

7. In Vitro Transformation of Monocytes and Dendritic Cells into Endothelial like Cells

   • Klaus Havemann, Beatriz F. Pujol, Jürgen Adamkiewicz

   Pages 47-57

8. Phenotypic Overlap between Monocytes and Vascular Endothelial Cells

   • Alexander Schmeisser, Christiane Graffy, Werner G. Daniel, Ruth H. Strasser

   Pages 59-74

9. Dissection of Monocyte and Endothelial Activities by Using VEGF-Receptor Specific Ligands

   • Matthias Clauss, Frederic Pipp, Katja Issbrücker, Herbert Weich, Matthias Heil, Wolfgang Schaper

   Pages 75-82

10. Circulating Endothelial Cells as a Novel Marker of Angiogenesis

    • Patrizia Mancuso, Angelica Calleri, Cristina Cassi, Alberto Gobbi, Manuela Capillo, Giancarlo Pruneri et al.

    Pages 83-97

11. Tissular Insemination of Progenitor Endothelial Cells: The Problem, and a Suggested Solution

    • Nicanor I. Moldovan

    Pages 99-113

12. Back Matter

    Pages 115-120

    PDF

New experimental observations often require fresh concepts for their interpretation, and at times even changes of paradigms. This is the situation with the recent realization that circulating endothelial progenitor cells may have an important contribution to the maintenance and formation of new endothelium in adult organisms, in a surprisingly wide variety of situations. The classical paradigm of angiogenesis, centered on the notion of "sprouting" can hardly accommodate them. It was previously realized that it needs to be "stretched out" to include alternative mechanisms of microvascular development, such as intussusception and capillary fusion. However, a major debate where to reconsider the sprouting mechanism, and to promote alternative views, did not take place yet. The number of publications in this field increased exponentially in the last years. Nevertheless, the concepts and notions so much needed to describe and to explain the new observations are still scarce, and heterogeneous. Within the larger community dedicated to the study of angiogenesis, the researchers involved in investigation of circulating precursor endothelial cells biology represent a subgroup with specific preoccupations and opinions. Many of them did not meet each other so far, and no major scientific events have been dedicated before exclusively to their interests. For the above reasons, the idea to organize a symposium addressing the new developments in angiogenesis research was received with enthusiasm by all those involved in its preparation.

• angiogenesis
• cardiovascular
• cells
• endothelium
• tissue

• The Ohio State University, Columbus, USA

  Nicanor I. Moldovan

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